Search Results - "HEIJINK, Irene H"

Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure by Aghapour, Mahyar, Raee, Pourya, Moghaddam, Seyed Javad, Hiemstra, Pieter S, Heijink, Irene H

“…The epithelial lining of the airway forms the first barrier against environmental insults, such as inhaled cigarette smoke, which is the primary risk factor…”
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Epithelial cell dysfunction, a major driver of asthma development by Heijink, Irene H., Kuchibhotla, Virinchi N. S., Roffel, Mirjam P., Maes, Tania, Knight, Darryl A., Sayers, Ian, Nawijn, Martijn C.

“…Airway epithelial barrier dysfunction is frequently observed in asthma and may have important implications. The physical barrier function of the airway…”
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Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD by Aghapour, Mahyar, Ubags, Niki D, Bruder, Dunja, Hiemstra, Pieter S, Sidhaye, Venkataramana, Rezaee, Fariba, Heijink, Irene H

“…Chronic exposure to environmental pollutants is a major contributor to the development and progression of obstructive airway diseases, including asthma and…”
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Defective Fibrillar Collagen Organization by Fibroblasts Contributes to Airway Remodeling in Asthma by Mostaço-Guidolin, Leila B, Osei, Emmanuel T, Ullah, Jari, Hajimohammadi, Soheil, Fouadi, May, Li, Xian, Li, Vicky, Shaheen, Furquan, Yang, Chen Xi, Chu, Fanny, Cole, Darren J, Brandsma, Corry-Anke, Heijink, Irene H, Maksym, Geoffrey N, Walker, David, Hackett, Tillie-Louise

“…Histologic stains have been used as the gold standard to visualize extracellular matrix (ECM) changes associated with airway remodeling in asthma, yet they…”
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Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice by Pouwels, Simon D, Zijlstra, G Jan, van der Toorn, Marco, Hesse, Laura, Gras, Renee, Ten Hacken, Nick H T, Krysko, Dmitri V, Vandenabeele, Peter, de Vries, Maaike, van Oosterhout, Antoon J M, Heijink, Irene H, Nawijn, Martijn C

“…Recent data indicate a role for airway epithelial necroptosis, a regulated form of necrosis, and the associated release of damage-associated molecular patterns…”
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Periostin: contributor to abnormal airway epithelial function in asthma? by Burgess, Janette K, Jonker, Marnix R, Berg, Marijn, Ten Hacken, Nick T H, Meyer, Kerstin B, van den Berge, Maarten, Nawijn, Martijn C, Heijink, Irene H

“…Periostin (POSTN) may serve as a biomarker for Type-2 mediated eosinophilic airway inflammation in asthma. We hypothesised that a Type-2 cytokine, interleukin…”
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miR-223: A Key Regulator in the Innate Immune Response in Asthma and COPD by Roffel, Mirjam P., Bracke, Ken R., Heijink, Irene H., Maes, Tania

“…Asthma and Chronic Obstructive Pulmonary Disease (COPD) are chronic obstructive respiratory diseases characterized by airway obstruction, inflammation, and…”
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E-cadherin: gatekeeper of airway mucosa and allergic sensitization by Nawijn, Martijn C, Hackett, Tillie L, Postma, Dirkje S, van Oosterhout, Antoon J.M, Heijink, Irene H

“…The airway epithelium plays a role in immune regulation during environmental challenge, which is intertwined with its barrier function and capacity to limit…”
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Host–device interactions: exposure of lung epithelial cells and fibroblasts to nickel, titanium, or nitinol affect proliferation, reactive oxygen species production, and cellular signaling by Pouwels, Simon D., Sigaeva, Alina, de Boer, Shanna, Eichhorn, Ilse A., Koll, Lisanne, Kuipers, Jeroen, Schirhagl, Romana, Heijink, Irene H., Burgess, Janette K., Slebos, Dirk-Jan

“…Endoscopic implantation of medical devices for the treatment of lung diseases, including airway stents, unidirectional valves and coils, is readily used to…”
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Collagen type XIV is proportionally lower in the lung tissue of patients with IPF by Nizamoglu, Mehmet, Koloko Ngassie, Maunick Lefin, Meuleman, Rhode A., Banchero, Martin, Borghuis, Theo, Timens, Wim, Nawijn, Martijn C., Melgert, Barbro N., Heijink, Irene H., Brandsma, Corry-Anke, Burgess, Janette K.

“…Abnormal deposition of extracellular matrix (ECM) in lung tissue is a characteristic of idiopathic pulmonary fibrosis (IPF). Increased collagen deposition is…”
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House Dust Mite-Promoted Epithelial-to-Mesenchymal Transition in Human Bronchial Epithelium by Heijink, Irene H, Postma, Dirkje S, Noordhoek, Jacobien A, Broekema, Martine, Kapus, Andras

“…The molecular basis of airway remodeling and loss of epithelial integrity in asthma is still undefined. We aimed to establish if exposure of human bronchial…”
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Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease by Heijink, Irene H, Noordhoek, Jacobien A, Timens, Wim, van Oosterhout, Antoon J M, Postma, Dirkje S

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Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells by Song, Juan, Cano-Rodriquez, David, Winkle, Melanie, Gjaltema, Rutger A F, Goubert, Désirée, Jurkowski, Tomasz P, Heijink, Irene H, Rots, Marianne G, Hylkema, Machteld N

“…Airway mucus hypersecretion contributes to the morbidity and mortality in patients with chronic inflammatory lung diseases. Reducing mucus production is…”
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Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma by Osei, Emmanuel T., B. Mostaço-Guidolin, Leila, Hsieh, Aileen, Warner, Stephanie M., AL-Fouadi, May, Wang, Mary, Cole, Darren J., Maksym, Geoffrey N., S. Hallstrand, Teal, Timens, Wim, Brandsma, Corry-Anke, Heijink, Irene H., Hackett, Tillie-Louise

“…In asthma, the airway epithelium has an impaired capacity to differentiate and plays a key role in the development of airway inflammation and remodeling…”
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Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation by Ng-Blichfeldt, John-Poul, Schrik, Anneke, Kortekaas, Rosa K., Noordhoek, Jacobien A., Heijink, Irene H., Hiemstra, Pieter S., Stolk, Jan, Königshoff, Melanie, Gosens, Reinoud

“…Despite compelling data describing pro-regenerative effects of all-trans retinoic acid (ATRA) in pre-clinical models of chronic obstructive pulmonary disease…”
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Gene network approach reveals co-expression patterns in nasal and bronchial epithelium by Imkamp, Kai, Bernal, Victor, Grzegorzcyk, Marco, Horvatovich, Peter, Vermeulen, Cornelis J., Heijink, Irene H., Guryev, Victor, Kerstjens, Huib A. M., van den Berge, Maarten, Faiz, Alen

“…Nasal gene expression profiling is a new approach to investigate the airway epithelium as a biomarker to study the activity and treatment responses of…”
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Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD by Faiz, Alen, Steiling, Katrina, Roffel, Mirjam P, Postma, Dirkje S, Spira, Avrum, Lenburg, Marc E, Borggrewe, Malte, Eijgenraam, Tim R, Jonker, Marnix R, Koppelman, Gerard H, Pouwels, Simon D, Liu, Gang, Alekseyev, Yuriy O, Lam, Stephen, Hiemstra, Pieter S, Sterk, Peter J, Timens, Wim, Brandsma, Corry-Anke, Heijink, Irene H, van den Berge, Maarten

“…The aim was to investigate whether microRNA (miRNA) expression is modulated by inhaled corticosteroid (ICS) treatmentWe performed genome-wide miRNA analysis on…”
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Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls by Kruk, Dennis, Yeung, Anna C Y, Faiz, Alen, Ten Hacken, Nick H T, Timens, Wim, van Kuppevelt, Toin H, Daamen, Willeke, Hof, Danique, Harmsen, Martin C, Rojas, Mauricio, Heijink, Irene H

“…Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured…”
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Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases by Joglekar, Mugdha M., Nizamoglu, Mehmet, Fan, YiWen, Nemani, Sai Sneha Priya, Weckmann, Markus, Pouwels, Simon D., Heijink, Irene H., Melgert, Barbro N., Pillay, Janesh, Burgess, Janette K.

“…Environmental insults including respiratory infections, in combination with genetic predisposition, may lead to lung diseases such as chronic obstructive…”
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Mesenchymal Stromal Cells to Regenerate Emphysema: On the Horizon? by Kruk, Dennis M L W, Heijink, Irene H, Slebos, Dirk-Jan, Timens, Wim, Ten Hacken, Nick H

“…Mesenchymal stem or stromal cells (MSCs) are multipotent cells that play a pivotal role in various phases of lung development and lung homeostasis, and…”
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