Search Results - "HEGELE, Richard G"

Identification of nucleolin as a cellular receptor for human respiratory syncytial virus by Tayyari, Farnoosh, Marchant, David, Moraes, Theo J, Duan, Wenming, Mastrangelo, Peter, Hegele, Richard G

“…Respiratory syncytial virus (RSV) is a common airway pathogen that can cause severe illness, yet there is no vaccine or effective therapy available. Tayyari et…”
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International consensus guideline for reporting transmission electron microscopy results in the diagnosis of primary ciliary dyskinesia (BEAT PCD TEM Criteria) by Shoemark, Amelia, Boon, Mieke, Brochhausen, Christoph, Bukowy-Bieryllo, Zuzanna, De Santi, Maria M, Goggin, Patricia, Griffin, Paul, Hegele, Richard G, Hirst, Robert A, Leigh, Margaret W, Lupton, Alison, MacKenney, Karen, Omran, Heymut, Pache, Jean-Claude, Pinto, Andreia, Reinholt, Finn P, Schroeder, Josep, Yiallouros, Panayotis, Escudier, Estelle

“…Primary ciliary dyskinesia (PCD) is a heterogeneous genetic condition. European and North American diagnostic guidelines recommend transmission electron…”
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A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity by Marchant, David J, Bellac, Caroline L, Moraes, Theo J, Wadsworth, Samuel J, Dufour, Antoine, Butler, Georgina S, Bilawchuk, Leanne M, Hendry, Reid G, Robertson, A Gordon, Cheung, Caroline T, Ng, Julie, Ang, Lisa, Luo, Zongshu, Heilbron, Karl, Norris, Michael J, Duan, Wenming, Bucyk, Taylor, Karpov, Andrei, Devel, Laurent, Georgiadis, Dimitris, Hegele, Richard G, Luo, Honglin, Granville, David J, Dive, Vincent, McManus, Bruce M, Overall, Christopher M

“…Matrix metalloproteinases (MMPs) normally act extracellularly. Now Marchant et al . report an unexpected nuclear activity for MMP-12 in virus-infected cells in…”
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Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution by Hackett, Tillie-Louise, Singhera, Gurpreet K, Shaheen, Furquan, Hayden, Patrick, Jackson, George R, Hegele, Richard G, Van Eeden, Stephan, Bai, Tony R, Dorscheid, Delbert R, Knight, Darryl A

“…A substantial proportion of healthcare cost associated with asthma is attributable to exacerbations of the disease. Within the airway, the epithelium forms the…”
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Toll-Like Receptor 4-Mediated Activation of p38 Mitogen-Activated Protein Kinase Is a Determinant of Respiratory Virus Entry and Tropism by MARCHANT, David, SINGHERA, Gurpreet K, UTOKAPARCH, Soraya, HACKETT, Tillie L, BOYD, John H, ZONGSHU LUO, XIAONING SI, DORSCHEID, Delbert R, MCMANUS, Bruce M, HEGELE, Richard G

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of RSV Fusion Protein Interaction Domains on the Virus Receptor, Nucleolin by Mastrangelo, Peter, Chin, Allysia A, Tan, Stephanie, Jeon, Amy H, Ackerley, Cameron A, Siu, Karen K, Lee, Jeffrey E, Hegele, Richard G

“…Nucleolin is an essential cellular receptor to human respiratory syncytial virus (RSV). Pharmacological targeting of the nucleolin RNA binding domain RBD1,2…”
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RSV fusion: time for a new model by Mastrangelo, Peter, Hegele, Richard G

“…In this review we propose a partially hypothetical model of respiratory syncytial virus (RSV) binding and entry to the cell that includes the recently…”
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Making sense of cell surface nucleolin: Implications for respiratory syncytial virus prophylaxis and therapy by Hegele, Richard G.

“…Comment on: Tayyari F, et al. Nat Med 2011; 17:1132-5…”
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Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes by Daley, Denise, PhD, Park, Julie E., MMath, He, Jian-Qing, MD, Yan, Jin, MMath, Akhabir, Loubna, BSc, Stefanowicz, Dorota, BSc, Becker, Allan B., MD, Chan-Yeung, Moira, MD, Bossé, Yohan, PhD, Kozyrskyj, Anita L., PhD, James, Alan L., MD, Musk, Arthur W., MD, Laprise, Catherine, PhD, Hegele, Richard G., MD, Paré, Peter D., MD, Sandford, Andrew J., PhD

“…Background The innate immune system is essential for host survival because of its ability to recognize invading pathogens and mount defensive responses…”
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Formation of a Stable Mimic of Ambient Particulate Matter Containing Viable Infectious Respiratory Syncytial Virus and Its Dry-Deposition Directly onto Cell Cultures by Cruz-Sanchez, Teresita M, Haddrell, Allen E, Hackett, Tillie L, Singhera, Gurpreet K, Marchant, David, Lekivetz, Ryan, Meredith, Anna, Horne, Derrick, Knight, Darryl A, van Eeden, Stephen F, Bai, Tony R, Hegele, Richard G, Dorscheid, Delbert R, Agnes, George R

“…Epidemiological associations of worse respiratory outcomes from combined exposure to ambient particulate matter (PM) and respiratory viral infection suggest…”
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Targeting Host Cell Surface Nucleolin for RSV Therapy: Challenges and Opportunities by Mastrangelo, Peter, Norris, Michael J, Duan, Wenming, Barrett, Edward G, Moraes, Theo J, Hegele, Richard G

“…Nucleolin (NCL) has been reported as a cellular receptor for the human respiratory syncytial virus (RSV). We studied the effects of re-purposing AS1411, an…”
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Evolutionary concepts in biobanking - the BC BioLibrary by Watson, Peter H, Wilson-McManus, Janet E, Barnes, Rebecca O, Giesz, Sara C, Png, Adrian, Hegele, Richard G, Brinkman, Jacquelyn N, Mackenzie, Ian R, Huntsman, David G, Junker, Anne, Gilks, Blake, Skarsgard, Erik, Burgess, Michael, Aparicio, Samuel, McManus, Bruce M

“…Medical research to improve health care faces a major problem in the relatively limited availability of adequately annotated and collected biospecimens. This…”
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Bosentan Enhances Viral Load via Endothelin-1 Receptor Type-A–Mediated p38 Mitogen-Activated Protein Kinase Activation While Improving Cardiac Function During Coxsackievirus-Induced Myocarditis by Marchant, David, Dou, Ying, Luo, Honglin, Garmaroudi, Farshid S, McDonough, John E, Si, Xiaoning, Walker, Elizabeth, Luo, Zongshu, Arner, Anders, Hegele, Richard G, Laher, Ismail, McManus, Bruce M

“…Reduced cardiac output is one of the consequences of myocarditis. Bosentan, an endothelin-1 receptor (ET1R) antagonist, could be useful to reduce cardiac…”
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The RSV fusion receptor: not what everyone expected it to be by Mastrangelo, Peter, Hegele, Richard G.

“…This article reviews current knowledge about respiratory syncytial virus (RSV) binding and entry into cells. The recent discovery of Nucleolin as a fusion…”
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Performance of residents using digital images versus glass slides on certification examination in anatomical pathology: a mixed methods pilot study by Mirham, Lorna, MD, Ismiil, Nadia, MD MBChB, Sade, Shachar, MD MSc, Streutker, Catherine, MD, MacMillan, Christina, MD, Rasty, Golnar, MD, Hegele, Richard G., MD PhD, Yousef, George M., MD PhD, Naugler, Christopher, MD, Hayes, Malcolm, MB ChB, Belisle, Annie, MD, Popovic, Snezana, MD, Joseph, Mariamma, MD, Gabril, Manal, MD, Barnes, Penny, MD, Carter, Beverley, MD

“…Abstract Background It is anticipated that many licensing examination centres for pathology will begin fully digitizing the certification examinations. The…”
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Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia by Ali, Salman, Hirschfeld, Aaron F, Mayer, Matthew L, Fortuno, 3rd, Edgardo S, Corbett, Nathan, Kaplan, Maia, Wang, Shirley, Schneiderman, Julia, Fjell, Christopher D, Yan, Jin, Akhabir, Loubna, Aminuddin, Farzian, Marr, Nico, Lacaze-Masmonteil, Thierry, Hegele, Richard G, Becker, Allan, Chan-Yeung, Moira, Hancock, Robert E W, Kollmann, Tobias R, Daley, Denise, Sandford, Andrew J, Lavoie, Pascal M, Turvey, Stuart E

“…Respiratory diseases are the most frequent chronic illnesses in babies and children. Although a vigorous innate immune system is critical for maintaining lung…”
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Common Respiratory Viruses in Lower Airways of Patients with Acute Hypersensitivity Pneumonitis by DAKHAMA, AZZEDDINE, HEGELE, RICHARD G, LAFLAMME, GENEVIeVE, ISRAeL-ASSAYAG, EVELYNE, CORMIER, YVON

“…Hypersensitivity pneumonitis (HP), a lung disease with "flulike" symptoms, results from repeated exposures to well defined, nonpathogenic antigens. This study…”
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The relationship between respiratory viral loads and diagnosis in children presenting to a pediatric hospital emergency department by Utokaparch, Soraya, Marchant, David, Gosselink, John V, McDonough, John E, Thomas, Eva E, Hogg, James C, Hegele, Richard G

“…respiratory viral infections account for a considerable proportion of pediatric emergency room visits. Illnesses range in severity from mild upper respiratory…”
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Respiratory syncytial virus receptor expression in the mouse and viral tropism by Shakeri, Aria, Mastrangelo, Peter, Griffin, Jennifer K, Moraes, Theo J, Hegele, Richard G

“…Human respiratory syncytial virus (RSV) infects airway epithelium and can cause serious illnesses such as bronchiolitis and pneumonia. With the discovery of…”
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Loss of GD1-positive Lactobacillus correlates with inflammation in human lungs with COPD by Sze, Marc A, Utokaparch, Soraya, Elliott, W Mark, Hogg, James C, Hegele, Richard G

“…Objectives The present study assesses the relationship between contents of GD1 (glycerol dehydratase)-positive Lactobacillus, presence of Lactobacillus and the…”
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