Search Results - "HEFFLER, ENRICO"

Interleukin-5 in the Pathophysiology of Severe Asthma by Pelaia, Corrado, Paoletti, Giovanni, Puggioni, Francesca, Racca, Francesca, Pelaia, Girolamo, Canonica, Giorgio Walter, Heffler, Enrico

“…Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils. Indeed, during the last…”
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Biologics and airway remodeling in severe asthma by Varricchi, Gilda, Ferri, Sebastian, Pepys, Jack, Poto, Remo, Spadaro, Giuseppe, Nappi, Emanuele, Paoletti, Giovanni, Virchow, Johann Christian, Heffler, Enrico, Canonica, Walter G.

“…Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in part can become irreversible to conventional therapies, defining the…”
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Misdiagnosis of asthma and COPD and underuse of spirometry in primary care unselected patients by Heffler, Enrico, Crimi, Claudia, Mancuso, Salvatore, Campisi, Raffaele, Puggioni, Francesca, Brussino, Luisa, Crimi, Nunzio

“…The diagnosis of both asthma and chronic obstructive pulmonary disease (COPD) consists of a combination of classical symptoms and signs, and the evidence of…”
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Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies by Jacobsen, Elizabeth A, Jackson, David J, Heffler, Enrico, Mathur, Sameer K, Bredenoord, Albert J, Pavord, Ian D, Akuthota, Praveen, Roufosse, Florence, Rothenberg, Marc E

“…The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses…”
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The Intriguing Role of Interleukin 13 in the Pathophysiology of Asthma by Marone, Giancarlo, Granata, Francescopaolo, Pucino, Valentina, Pecoraro, Antonio, Heffler, Enrico, Loffredo, Stefania, Scadding, Guy W, Varricchi, Gilda

“…Approximately 5-10% of asthmatic patients worldwide suffer from severe asthma. Experimental and clinical studies have demonstrated that IL-13 is an important…”
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Diagnosis and management of NSAID‐Exacerbated Respiratory Disease (N‐ERD)—a EAACI position paper by Kowalski, Marek L., Agache, Ioana, Bavbek, Sevim, Bakirtas, Arzu, Blanca, Miguel, Bochenek, Grażyna, Bonini, Matteo, Heffler, Enrico, Klimek, Ludger, Laidlaw, Tanya M., Mullol, Joaquim, Niżankowska‐Mogilnicka, Ewa, Park, Hae‐Sim, Sanak, Marek, Sanchez‐Borges, Mario, Sanchez‐Garcia, Silvia, Scadding, Glenis, Taniguchi, Masami, Torres, Maria J., White, Andrew A., Wardzyńska, Aleksandra

“…NSAID‐exacerbated respiratory disease (N‐ERD) is a chronic eosinophilic, inflammatory disorder of the respiratory tract occurring in patients with asthma…”
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Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets by Pelaia, Corrado, Heffler, Enrico, Crimi, Claudia, Maglio, Angelantonio, Vatrella, Alessandro, Pelaia, Girolamo, Canonica, Giorgio Walter

“…Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation,…”
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Toward clinically applicable biomarkers for asthma: An EAACI position paper by Diamant, Zuzana, Vijverberg, Susanne, Alving, Kjell, Bakirtas, Arzu, Bjermer, Leif, Custovic, Adnan, Dahlen, Sven‐Erik, Gaga, Mina, Gerth van Wijk, Roy, Giacco, Stefano Del, Hamelmann, Eckard, Heaney, Liam G., Heffler, Enrico, Kalayci, Ömer, Kostikas, Konstantinos, Lutter, Rene, Olin, Anna‐Carin, Sergejeva, Svetlana, Simpson, Angela, Sterk, Peter J., Tufvesson, Ellen, Agache, Ioana, Seys, Sven F.

“…Inflammation, structural, and functional abnormalities within the airways are key features of asthma. Although these processes are well documented, their…”
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Minimal clinically important difference for asthma endpoints: an expert consensus report by Bonini, Matteo, Di Paolo, Marcello, Bagnasco, Diego, Baiardini, Ilaria, Braido, Fulvio, Caminati, Marco, Carpagnano, Elisiana, Contoli, Marco, Corsico, Angelo, Del Giacco, Stefano, Heffler, Enrico, Lombardi, Carlo, Menichini, Ilaria, Milanese, Manlio, Scichilone, Nicola, Senna, Gianenrico, Canonica, Giorgio W

“…Minimal clinically important difference (MCID) can be defined as the smallest change or difference in an outcome measure that is perceived as beneficial and…”
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Extended IgE profile based on an allergen macroarray: a novel tool for precision medicine in allergy diagnosis by Heffler, Enrico, Puggioni, Francesca, Peveri, Silvia, Montagni, Marcello, Canonica, Giorgio Walter, Melioli, Giovanni

“…Precision medicine (PM) is changing the scope of allergy diagnosis and treatment. An in vitro IgE assay, a prototype PM method, was developed in the sixties…”
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Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19 by Carenzo, Luca, Protti, Alessandro, Dalla Corte, Francesca, Aceto, Romina, Iapichino, Giacomo, Milani, Angelo, Santini, Alessandro, Chiurazzi, Chiara, Ferrari, Michele, Heffler, Enrico, Angelini, Claudio, Aghemo, Alessio, Ciccarelli, Michele, Chiti, Arturo, Iwashyna, Theodore J., Herridge, Margaret S., Cecconi, Maurizio

“…Background Survivors of severe COVID-19 are at risk of impaired health-related quality of life (HRQoL) and persistent physical and psychological disability…”
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One year of mepolizumab. Efficacy and safety in real-life in Italy by Bagnasco, Diego, Caminati, Marco, Menzella, Francesco, Milanese, Manlio, Rolla, Giovanni, Lombardi, Carlo, Bucca, Caterina, Heffler, Enrico, Paoletti, Giovanni, Testino, Elisa, Manfredi, Andrea, Caruso, Cristiano, Guida, Giuseppe, Senna, Gianenrico, Bonavia, Marco, Riccio, Anna Maria, Canonica, Giorgio Walter, Passalacqua, Giovanni

“…Severe asthma is a disease with a heavy socio-economic burden and a relevant impact on the life of patients. Mepolizumab (MEP) was recently introduced in…”
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Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets by Racca, Francesca, Pellegatta, Gaia, Cataldo, Giuseppe, Vespa, Edoardo, Carlani, Elisa, Pelaia, Corrado, Paoletti, Giovanni, Messina, Maria Rita, Nappi, Emanuele, Canonica, Giorgio Walter, Repici, Alessandro, Heffler, Enrico

“…Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus characterized clinically by symptoms related to esophageal dysfunction and…”
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Exhaled nitric oxide's ability to predict methacholine challenge by Heffler, Enrico, MD, PhD

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Release of Type 2 Cytokines by Epithelial Cells of Nasal Polyps by Heffler, Enrico, Riva, Giuseppe, Bucca, Caterina, Boita, Monica, Rolla, Giovanni

“…Background. T2 inflammation of chronic rhinosinusitis with nasal polyps (CRSwNP) may be influenced by epithelial cytokines release (TSLP, IL-25, and IL-33). We…”
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Airways Type-2 Related Disorders: Multiorgan, Systemic or Syndemic Disease? by Giombi, Francesco, Pace, Gian Marco, Pirola, Francesca, Cerasuolo, Michele, Ferreli, Fabio, Mercante, Giuseppe, Spriano, Giuseppe, Canonica, Giorgio Walter, Heffler, Enrico, Ferri, Sebastian, Puggioni, Francesca, Paoletti, Giovanni, Malvezzi, Luca

“…Chronic rhinosinusitis (CRS) has recently undergone a significant paradigm shift, moving from a phenotypical classification towards an "endotype-based"…”
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Mast Cells in Upper and Lower Airway Diseases: Sentinels in the Front Line by Costanzo, Giovanni, Costanzo, Giulia Anna Maria Luigia, Del Moro, Lorenzo, Nappi, Emanuele, Pelaia, Corrado, Puggioni, Francesca, Canonica, Giorgio Walter, Heffler, Enrico, Paoletti, Giovanni

“…Mast cells (MCs) are fascinating cells of the innate immune system involved not only in allergic reaction but also in tissue homeostasis, response to…”
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Effectiveness of omalizumab in patients with severe allergic asthma with and without chronic rhinosinusitis with nasal polyps: a PROXIMA study post hoc analysis by Heffler, Enrico, Saccheri, Fabiana, Bartezaghi, Marta, Canonica, Giorgio Walter

“…Background A significant proportion of patients with severe asthma may also suffer from nasal polyposis, which is commonly defined as chronic rhinosinusitis…”
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Predictors of reversible airway obstruction with omalizumab in severe asthma: a real-life study by Solidoro, Paolo, Patrucco, Filippo, de Blasio, Francesca, Brussino, Luisa, Bellocchia, Michela, Dassetto, Davide, Pivetta, Emanuele, Riccio, Annamaria, Heffler, Enrico, Canonica, Walter, Rolla, Giovanni, Bucca, Caterina

“…Background: Omalizumab may modulate airway remodeling in severe asthma. Using forced expiratory volume in 1 second (FEV1) as a surrogate of airway remodeling,…”
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Cutting Edge: Biomarkers for Chronic Spontaneous Urticaria by Furlan, Raffaello, Canonica, Giorgio Walter, Heffler, Enrico, Folci, Marco, Brunetta, Enrico

“…Chronic spontaneous urticaria (CSU) is defined by the appearance of wheals and a variable presence of angioedema which persists for at least 6 weeks. It…”
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