Search Results - "HEEMSKERK, Mirjam H. M"

Reassessing human MHC-I genetic diversity in T cell studies by Slieker, Roderick C., Warmerdam, Daniël O., Vermeer, Maarten H., van Doorn, Remco, Heemskerk, Mirjam H. M., Scheeren, Ferenc A.

“…The Major Histocompatibility Complex class I (MHC-I) system plays a vital role in immune responses by presenting antigens to T cells. Allele specific…”
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Mixed T cell receptor dimers harbor potentially harmful neoreactivity by van Loenen, Marleen M., de Boer, Renate, Amir, Avital L., Hagedoorn, Renate S., Volbeda, Gerdien L., Willemze, Roelof, van Rood, Johannes J., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

“…Adoptive transfer of T cell receptor (TCR)-transduced T cells may be an attractive strategy to target both hematological malignancies and solid tumors. By…”
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PRAME-Specific Allo-HLA―Restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-Cell Receptor Gene Transfer by AMIR, Avital L, VAN DER STEEN, Dirk M, JEDEMA, Inge, GRIFFIOEN, Marieke, VAN VEELEN, Peter A, FALKENBURG, J. H. Frederik, HEEMSKERK, Mirjam H. M, VAN LOENEN, Marleen M, HAGEDOORN, Renate S, DE BOER, Renate, KESTER, Michel D. G, DE RU, Arnoud H, LUGTHART, Gert-Jan, VAN KOOTEN, Cees, HIEMSTRA, Pieter S

“…In human leukocyte antigen (HLA)-matched stem cell transplantation (SCT), it has been shown that beneficial immune response mediating graft-versus-tumor (GVT)…”
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SARS-CoV-2-specific CD4 + and CD8 + T cell responses can originate from cross-reactive CMV-specific T cells by Pothast, Cilia R, Dijkland, Romy C, Thaler, Melissa, Hagedoorn, Renate S, Kester, Michel G D, Wouters, Anne K, Hiemstra, Pieter S, van Hemert, Martijn J, Gras, Stephanie, Falkenburg, J H Frederik, Heemskerk, Mirjam H M

“…Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific CD4 and CD8 T cells in SARS-CoV-2-unexposed donors has been explained by the…”
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Immunogenicity and reactogenicity of intradermal mRNA-1273 SARS-CoV-2 vaccination: a non-inferiority, randomized-controlled trial by Prins, Manon L. M., Roozen, Geert V. T., Pothast, Cilia. R., Huisman, Wesley, van Binnendijk, Rob, den Hartog, Gerco, Kuiper, Vincent P., Prins, Corine, Janse, Jacqueline J., Lamers, Olivia. A. C., Koopman, Jan Pieter R., Kruithof, Annelieke C., Kamerling, Ingrid M. C., Dijkland, Romy C., de Kroon, Alicia. C., Azimi, Shohreh, Feltkamp, Mariet C. W., Kuijer, Marjan, Jochems, Simon P., Heemskerk, Mirjam H. M., Rosendaal, Frits R., Roestenberg, Meta, Visser, Leo G., Roukens, Anna H. E.

“…Fractional dosing can be a cost-effective vaccination strategy to accelerate individual and herd immunity in a pandemic. We assessed the immunogenicity and…”
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Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7 by Bakker, Arnold H, Hoppes, Rieuwert, Linnemann, Carsten, Toebes, Mireille, Rodenko, Boris, Berkers, Celia R, Hadrup, Sine Reker, van Esch, Wim J.E, Heemskerk, Mirjam H.M, Ovaa, Huib, Schumacher, Ton N.M

“…Major histocompatibility complex (MHC) class I multimer technology has become an indispensable immunological assay system to dissect antigen-specific cytotoxic…”
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High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations by Hombrink, Pleun, Hadrup, Sine R, Bakker, Arne, Kester, Michel G D, Falkenburg, J H Frederik, von dem Borne, Peter A, Schumacher, Ton N M, Heemskerk, Mirjam H M

“…T-cell recognition of minor histocompatibility antigens (MiHA) plays an important role in the graft-versus-tumor (GVT) effect of allogeneic stem cell…”
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The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells by Gram, Anna M, Oosenbrug, Timo, Lindenbergh, Marthe F S, Büll, Christian, Comvalius, Anouskha, Dickson, Kathryn J I, Wiegant, Joop, Vrolijk, Hans, Lebbink, Robert Jan, Wolterbeek, Ron, Adema, Gosse J, Griffioen, Marieke, Heemskerk, Mirjam H M, Tscharke, David C, Hutt-Fletcher, Lindsey M, Wiertz, Emmanuel J H J, Hoeben, Rob C, Ressing, Maaike E

“…Cell-mediated immunity plays a key role in host control of viral infection. This is exemplified by life-threatening reactivations of e.g. herpesviruses in…”
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PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma by Gezgin, Gülçin, Luk, Sietse J, Cao, Jinfeng, Dogrusöz, Mehmet, van der Steen, Dirk M, Hagedoorn, Renate S, Krijgsman, Daniëlle, van der Velden, Pieter A, Field, Matthew G, Luyten, Gregorius P M, Szuhai, Karoly, Harbour, J William, Jordanova, Ekaterina S, Heemskerk, Mirjam H M, Jager, Martine J

“…Uveal melanoma (UM) is an intraocular primary malignant neoplasm that often gives rise to metastatic disease for which there are no effective therapies. A…”
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Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies by Kroonen, Jessie S., de Graaf, Ilona J., Kumar, Sumit, Remst, Dennis F. G., Wouters, Anne K., Heemskerk, Mirjam H. M., Vertegaal, Alfred C. O.

“…Combination therapies targeting malignancies aim to increase treatment efficacy and reduce toxicity. Hypomethylating drug 5-Aza-2’-deoxycytidine (5-Aza-2’)…”
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Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function by Thomas, Sharyn, Mohammed, Fiyaz, Reijmers, Rogier M., Woolston, Annemarie, Stauss, Theresa, Kennedy, Alan, Stirling, David, Holler, Angelika, Green, Louisa, Jones, David, Matthews, Katherine K., Price, David A., Chain, Benjamin M., Heemskerk, Mirjam H. M., Morris, Emma C., Willcox, Benjamin E., Stauss, Hans J.

“…TCR-gene-transfer is an efficient strategy to produce therapeutic T cells of defined antigen specificity. However, there are substantial variations in the cell…”
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Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity by Zhang, Yi, Liu, Yeuying, Moxley, Kelly M, Golden-Mason, Lucy, Hughes, Michael G, Liu, Tongxin, Heemskerk, Mirjam H M, Rosen, Hugo R, Nishimura, Michael I

“…Hepatitis C Virus (HCV) is a major public health concern, with no effective vaccines currently available and 3% of the world's population being infected…”
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Allo-HLA reactivity of virus-specific memory T cells is common by Amir, Avital L, D'Orsogna, Lloyd J.A, Roelen, Dave L, van Loenen, Marleen M, Hagedoorn, Renate S, de Boer, Renate, van der Hoorn, Menno A.W.G, Kester, Michel G.D, Doxiadis, Ilias I.N, Falkenburg, J. H. Frederik, Claas, Frans H.J, Heemskerk, Mirjam H.M

“…Graft-versus-host disease and graft rejection are major complications of allogeneic HLA-mismatched stem cell transplantation or organ transplantation that are…”
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The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses by Jongsma, Marlieke L.M., de Waard, Antonius A., Raaben, Matthijs, Zhang, Tao, Cabukusta, Birol, Platzer, René, Blomen, Vincent A., Xagara, Anastasia, Verkerk, Tamara, Bliss, Sophie, Kong, Xiangrui, Gerke, Carolin, Janssen, Lennert, Stickel, Elmer, Holst, Stephanie, Plomp, Rosina, Mulder, Arend, Ferrone, Soldano, Claas, Frans H.J., Heemskerk, Mirjam H.M., Griffioen, Marieke, Halenius, Anne, Overkleeft, Hermen, Huppa, Johannes B., Wuhrer, Manfred, Brummelkamp, Thijn R., Neefjes, Jacques, Spaapen, Robbert M.

“…HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8+ T cells. This process is often hijacked by tumors and pathogens…”
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Human CD34+-derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8+ T cell and NK cell responses in vitro and in vivo by van Eck van der Sluijs, Jesper, van Ens, Diede, Brummelman, Jolanda, Heister, Daan, Sareen, Aastha, Truijen, Lisa, van Ingen Schenau, Dorette S., Heemskerk, Mirjam H. M., Griffioen, Marieke, Kester, Michel G. D., Schaap, Nicolaas P. M., Jansen, Joop H., van der Waart, Anniek B., Dolstra, Harry, Hobo, Willemijn

“…Allogeneic stem cell transplantation (alloSCT) can be curative for hemato-oncology patients due to effective graft-versus-tumor immunity. However, relapse…”
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High-throughput identification of antigen-specific TCRs by TCR gene capture by Linnemann, Carsten, Heemskerk, Bianca, Kvistborg, Pia, Kluin, Roelof J C, Bolotin, Dmitriy A, Chen, Xiaojing, Bresser, Kaspar, Nieuwland, Marja, Schotte, Remko, Michels, Samira, Gomez-Eerland, Raquel, Jahn, Lorenz, Hombrink, Pleun, Legrand, Nicolas, Shu, Chengyi Jenny, Mamedov, Ilgar Z, Velds, Arno, Blank, Christian U, Haanen, John B A G, Turchaninova, Maria A, Kerkhoven, Ron M, Spits, Hergen, Hadrup, Sine Reker, Heemskerk, Mirjam H M, Blankenstein, Thomas, Chudakov, Dmitriy M, Bendle, Gavin M, Schumacher, Ton N M

“…The lack of robust and high-throughput technologies to analyze the human TCR repertoire has been a bottleneck in the analysis of human T cell responses…”
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Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients by Pfistershammer, Katharina, Lawitschka, Anita, Klauser, Christoph, Leitner, Judith, Weigl, Roman, Heemskerk, Mirjam H.M., Pickl, Winfried F., Majdic, Otto, Böhmig, Georg A., Fischer, Gottfried F., Greinix, Hildegard T., Steinberger, Peter

“…In hematopoietic stem cell transplant (HSCT) recipients, the recognition of polymorphic antigens by the donor-derived immune system is an important mechanism…”
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Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure by Wachsmann, Tassilo L. A., Wouters, Anne K., Remst, Dennis F. G., Hagedoorn, Renate S., Meeuwsen, Miranda H., van Diest, Eline, Leusen, Jeanette, Kuball, Jürgen, Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

“…Chimeric antigen receptor (CAR) T cell therapies have resulted in profound clinical responses in the treatment of CD19-positive hematological malignancies, but…”
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Adoptive Immunotherapy Using PRAME-Specific T Cells in Medulloblastoma by Orlando, Domenico, Miele, Evelina, De Angelis, Biagio, Guercio, Marika, Boffa, Iolanda, Sinibaldi, Matilde, Po, Agnese, Caruana, Ignazio, Abballe, Luana, Carai, Andrea, Caruso, Simona, Camera, Antonio, Moseley, Annemarie, Hagedoorn, Renate S, Heemskerk, Mirjam H M, Giangaspero, Felice, Mastronuzzi, Angela, Ferretti, Elisabetta, Locatelli, Franco, Quintarelli, Concetta

“…Medulloblastoma is the most frequent malignant childhood brain tumor with a high morbidity. Identification of new therapeutic targets would be instrumental in…”
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Functional Human Antigen-Specific T Cells Produced In Vitro Using Retroviral T Cell Receptor Transfer into Hematopoietic Progenitors by van Lent, Anja U, Nagasawa, Maho, van Loenen, Marleen M, Schotte, Remko, Schumacher, Ton N. M, Heemskerk, Mirjam H. M, Spits, Hergen, Legrand, Nicolas

“…In vitro production of human T cells with known Ag specificity is of major clinical interest for immunotherapy against tumors and infections. We have performed…”
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