Search Results - "HEDNER, Jan"

New pharmacologic agents for obstructive sleep apnoea: what do we know and what can we expect? by Hedner, Jan, Zou, Ding

“…PURPOSE OF REVIEWThis review provides a condensed description of pharmacological remedies explored in patients with obstructive sleep apnoea (OSA) as well as…”
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Sleep apnea-related risk of motor vehicle accidents is reduced by continuous positive airway pressure: Swedish Traffic Accident Registry data by Karimi, Mahssa, Hedner, Jan, Häbel, Henrike, Nerman, Olle, Grote, Ludger

“…Obstructive sleep apnea (OSA) is associated with an increased risk of motor vehicle accidents (MVAs). The rate of MVAs in patients suspected of having OSA was…”
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Changes in cognitive function and daytime sleepiness in patients with chronic heart failure and Cheyne-Stokes respiration with adaptive servo ventilation treatment by Karimi, Mahssa, Hedner, Jan, Grote, Ludger

“…Cheyne - Stokes respiration (CSR) is prevalent in patients with chronic heart failure (CHF). Adaptive Servo Ventilation (ASV) alleviates CSR and improves…”
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Turning Over a New Leaf—Pharmacologic Therapy in Obstructive Sleep Apnea by Hedner, Jan, Zou, Ding

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Daridorexant, a New Dual Orexin Receptor Antagonist to Treat Insomnia Disorder by Dauvilliers, Yves, Zammit, Gary, Fietze, Ingo, Mayleben, David, Seboek Kinter, Dalma, Pain, Scott, Hedner, Jan

“…Objective To evaluate the dose–response relationship of daridorexant, a new dual orexin receptor antagonist, on sleep variables in subjects with insomnia…”
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The influence of diabetes on sleep-derived cardiorespiratory features of the finger pulse wave signal – The population-based SCAPIS study by Strassberger, Christian, Hedner, Jan, Sommermeyer, Dirk, Zou, Ding, Grote, Ludger

“…Advanced signal processing of photoplethysmographic data enables novel analyses which may improve the understanding of the pathogenesis of dysglycemia…”
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A Randomized Controlled Clinical Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea by Hedner, Jan, Stenlöf, Kaj, Zou, Ding, Hoff, Erik, Hansen, Corinna, Kuhn, Katrin, Lennartz, Peter, Grote, Ludger

“…Current therapies for obstructive sleep apnea (OSA) are limited by insufficient efficacy, compliance, or tolerability. An effective pharmacological treatment…”
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Modification of Endotypic Traits in OSA by the Carbonic Anhydrase Inhibitor Sulthiame by Hoff, Erik, Strassberger, Christian, Zou, Ding, Grote, Ludger, Stenlöf, Kaj, Hedner, Jan

“…The carbonic anhydrase inhibitor sulthiame reduces OSA severity, increases overnight oxygenation, and improves sleep quality. Insights into how sulthiame…”
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Pitolisant for Daytime Sleepiness in Patients with Obstructive Sleep Apnea Who Refuse Continuous Positive Airway Pressure Treatment. A Randomized Trial by Dauvilliers, Yves, Verbraecken, Johan, Partinen, Markku, Hedner, Jan, Saaresranta, Tarja, Georgiev, Ognian, Tiholov, Rumen, Lecomte, Isabelle, Tamisier, Renaud, Lévy, Patrick, Scart-Gres, Catherine, Lecomte, Jeanne-Marie, Schwartz, Jean-Charles, Pépin, Jean-Louis

“…Excessive daytime sleepiness is a common disabling symptom in obstructive sleep apnea syndrome. To evaluate the efficacy and safety of pitolisant, a selective…”
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Acetazolamide Reduces Blood Pressure and Sleep-Disordered Breathing in Patients With Hypertension and Obstructive Sleep Apnea: A Randomized Controlled Trial by Eskandari, Davoud, Zou, Ding, Grote, Ludger, Hoff, Erik, Hedner, Jan

“…The carbonic anhydrase inhibitor acetazolamide (AZT) modulates blood pressure at high altitude and reduces sleep-disordered breathing in patients with…”
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The placebo effect in pharmacological treatment of obstructive sleep apnea, a systematic review and meta-analysis by Hoff, Erik, Zou, Ding, Grote, Ludger, Stenlöf, Kaj, Hedner, Jan

“…New drug treatments are under development in obstructive sleep apnea (OSA). The placebo effect is well recognized in various conditions, but its relevance in…”
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Eveningness is associated with sedentary behavior and increased 10-year risk of cardiovascular disease: the SCAPIS pilot cohort by Kobayashi Frisk, Mio, Hedner, Jan, Grote, Ludger, Ekblom, Örjan, Arvidsson, Daniel, Bergström, Göran, Börjesson, Mats, Zou, Ding

“…Chronotype reflects individual preferences for timing activities throughout the day, determined by the circadian system, environment and behavior. The…”
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A randomized, double-blind, placebo controlled, multi-center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome by Grote, Ludger, Leissner, Lena, Hedner, Jan, Ulfberg, Jan

“…Iron deficiency may exacerbate symptoms in the Restless Legs Syndrome (RLS). We investigated the effect of intravenous iron sucrose or placebo on symptoms in…”
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Clinical Phenotypes and Comorbidity in European Sleep Apnoea Patients by Saaresranta, Tarja, Hedner, Jan, Bonsignore, Maria R, Riha, Renata L, McNicholas, Walter T, Penzel, Thomas, Anttalainen, Ulla, Kvamme, John Arthur, Pretl, Martin, Sliwinski, Pawel, Verbraecken, Johan, Grote, Ludger

“…Clinical presentation phenotypes of obstructive sleep apnoea (OSA) and their association with comorbidity as well as impact on adherence to continuous positive…”
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Correlates of excessive daytime sleepiness in obstructive sleep apnea: Results from the nationwide SESAR cohort including 34,684 patients by Ulander, Martin, Hedner, Jan, Stillberg, Göran, Sunnergren, Ola, Grote, Ludger

“…Summary Excessive daytime sleepiness (EDS) is a hallmark symptom in obstructive sleep apnea (OSA). It is commonly eliminated by obstructive sleep apnea therapy…”
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Modafinil/armodafinil in obstructive sleep apnoea: a systematic review and meta-analysis by Chapman, Julia L, Vakulin, Andrew, Hedner, Jan, Yee, Brendon J, Marshall, Nathaniel S

“…Modafinil is used internationally to treat residual sleepiness despite continuous positive airway pressure in obstructive sleep apnoea (res-OSA). In 2011, the…”
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Drug Therapy in Obstructive Sleep Apnea by Hedner, Jan, Zou, Ding

“…There are several reasons to develop a pharmacologic remedy in obstructive sleep apnea (OSA); but so far, there is no generally effective drug available…”
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Night-to-Night Variability of Polysomnography-Derived Physiologic Endotypic Traits in Patients With Moderate to Severe OSA by Strassberger, Christian, Hedner, Jan, Sands, Scott A., Tolbert, Thomas M., Taranto-Montemurro, Luigi, Marciniak, Albert, Zou, Ding, Grote, Ludger

“…Emerging data suggest that determination of physiologic endotypic traits (eg, loop gain) may enable precision medicine in OSA. Does a single-night assessment…”
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Certification of fitness to drive in sleep apnea patients: Are we doing the right thing? by Grote, Ludger, Svedmyr, Sven, Hedner, Jan

“…New European Union (EU) regulations state that untreated moderate to severe obstructive sleep apnea (OSA) coincident with excessive daytime sleepiness (EDS)…”
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Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study by TKACOVA, Ruzena, MCNICHOLAS, Walter T, JAVORSKY, Martin, FIETZE, Ingo, SLIWINSKI, Pawel, PARATI, Gianfranco, GROTE, Ludger, HEDNER, Jan

“…Systemic hypertension is associated with obstructive sleep apnoea syndrome (OSAS) but the pathophysiological mechanisms are incompletely understood. A…”
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