Search Results - "HEDGES, Laura"

Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs by McTier, Tom L., Chubb, Nathan, Curtis, Michael P., Hedges, Laura, Inskeep, Gregory A., Knauer, Christopher S., Menon, Sanjay, Mills, Brian, Pullins, Aleah, Zinser, Erich, Woods, Debra J., Meeus, Patrick

“…•The novel isoxazoline, sarolaner, was designed in Zoetis research laboratories, specifically for use in companion animals.•Sarolaner, the chirally pure…”
Get full text

Pharmacokinetic Interaction of the Antiparasitic Agents Ivermectin and Spinosad in Dogs by DUNN, Stewart T, HEDGES, Laura, SAMPSON, Kathleen E, YURONG LAI, MAHABIR, Sean, BALOGH, Larissa, LOCUSON, Charles W

“…Neurological side effects consistent with ivermectin toxicity have been observed in dogs when high doses of the common heartworm prevention agent ivermectin…”
Get full text

The efficacy of a topical formulation of selamectin plus sarolaner in preventing the development of a macrocyclic lactone-resistant strain of Dirofilaria immitis in cats by Pullins, Aleah, McTier, Tom L., Mahabir, Sean, DeRose, Guy, Hedges, Laura

“…Revolution®/Stronghold® Plus, a topical endectocide incorporating 6 mg/kg selamectin plus 1 mg/kg sarolaner, is approved for use in cats to prevent heartworm…”
Get full text

Metabolism of deltamethrin and cis- and trans-permethrin by rat and human liver microsomes, liver cytosol and plasma preparations by Hedges, Laura, Brown, Susan, Vardy, Audrey, Doyle, Edward, Yoon, Miyoung, Osimitz, Thomas G., Lake, Brian G.

“…The metabolism of deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in liver microsomes, liver cytosol and plasma from male…”
Get full text

Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes by Hedges, Laura, Brown, Susan, MacLeod, A Kenneth, Vardy, Audrey, Doyle, Edward, Song, Gina, Moreau, Marjory, Yoon, Miyoung, Osimitz, Thomas G, Lake, Brian G

“…The metabolism of the pyrethroids deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in human expressed cytochrome P450 (CYP) and…”
Get full text

Metabolism of bifenthrin, β-cyfluthrin, λ-cyhalothrin, cyphenothrin and esfenvalerate by rat and human cytochrome P450 and carboxylesterase enzymes by Hedges, Laura, Brown, Susan, MacLeod, A. Kenneth, Moreau, Marjory, Yoon, Miyoung, Creek, Moire R., Osimitz, Thomas G., Lake, Brian G.

“…The metabolism of bifenthrin (BIF), β-cyfluthrin (CYFL), λ-cyhalothrin (CYHA), cyphenothrin (CYPH) and esfenvalerate (ESF) was studied in liver microsomes,…”
Get full text

Determination of the effective dose of a novel oral formulation of sarolaner (Simparica™) for the treatment and month-long control of fleas and ticks on dogs by McTier, Tom L., Six, Robert H., Fourie, Josephus J., Pullins, Aleah, Hedges, Laura, Mahabir, Sean P., Myers, Melanie R.

“…•Doses (0.625–5mg/kg) of sarolaner were tested to assess efficacy against fleas and ticks for one month.•Fleas were susceptible and Amblyomma spp. were the…”
Get full text

Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs by Curtis, Michael P., Vaillancourt, Valerie, Goodwin, Richard M., Chubb, Nathan A.L., Howson, William, McTier, Tom L., Pullins, Aleah, Zinser, Erich W., Meeus, Patrick F.M., Woods, Debra J., Hedges, Laura, Stuk, Tim, Price, Jeffrey E., Koch, Jason D., Menon, Sanjay R.

“…[Display omitted] Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for…”
Get full text

Public Policy Foundations for Positive Behavioral Interventions, Strategies, and Supports by Turnbull, H. Rutherford, Wilcox, Brennan L., Stowe, Matthew, Raper, Carolyn, Hedges, Laura Penny

“…This article examines precedents that justify Congress in creating a preference for positive behavioral interventions, strategies, and supports over other…”
Get full text