Search Results - "HEDBORG, Fredrik"

The Risk-Associated Long Noncoding RNA NBAT-1 Controls Neuroblastoma Progression by Regulating Cell Proliferation and Neuronal Differentiation by Pandey, Gaurav Kumar, Mitra, Sanhita, Subhash, Santhilal, Hertwig, Falk, Kanduri, Meena, Mishra, Kankadeb, Fransson, Susanne, Ganeshram, Abiarchana, Mondal, Tanmoy, Bandaru, Sashidhar, Östensson, Malin, Akyürek, Levent M., Abrahamsson, Jonas, Pfeifer, Susan, Larsson, Erik, Shi, Leming, Peng, Zhiyu, Fischer, Matthias, Martinsson, Tommy, Hedborg, Fredrik, Kogner, Per, Kanduri, Chandrasekhar

“…Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low-…”
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The Angiogenic Growth Factors HGF and VEGF in Serum and Plasma from Neuroblastoma Patients by SKOLDENBERG, Erik G, LARSSON, Anders, JAKOBSON, Ake, HEDBORG, Fredrik, KOGNER, Per, CHRISTOFFERSON, Rolf H, AZARBAYJANI, Faranak

“…Aim: To determine whether concentrations of the angiogenic growth factors hepatocyte growth factor (HGF) and vascular endothelial growth factor A (VEGF-A)…”
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Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype by Hedborg, Fredrik, Fischer-Colbrie, Reiner, Ostlin, Nurtena, Sandstedt, Bengt, Tran, Maxine G B, Maxwell, Patrick H

“…Neuroblastoma is a childhood malignancy of sympathetic embryonal origin. A high potential for differentiation is a hallmark of neuroblastoma cells. We have…”
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Inhibition of Angiogenesis Induces Chromaffin Differentiation and Apoptosis in Neuroblastoma by Wassberg, Erik, Hedborg, Fredrik, Sköldenberg, Erik, Stridsberg, Mats, Christofferson, Rolf

“…Inhibition of angiogenesis has been shown to reduce tumor growth, metastasis, and tumor microvascular density in experimental models. To these effects we would…”
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Emergence of new ALK mutations at relapse of neuroblastoma by Schleiermacher, Gudrun, Javanmardi, Niloufar, Bernard, Virginie, Leroy, Quentin, Cappo, Julie, Rio Frio, Thomas, Pierron, Gaelle, Lapouble, Eve, Combaret, Valérie, Speleman, Frank, de Wilde, Bram, Djos, Anna, Ora, Ingrid, Hedborg, Fredrik, Träger, Catarina, Holmqvist, Britt-Marie, Abrahamsson, Jonas, Peuchmaur, Michel, Michon, Jean, Janoueix-Lerosey, Isabelle, Kogner, Per, Delattre, Olivier, Martinsson, Tommy

“…In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated the potential role of ALK mutations in neuroblastoma clonal…”
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Dynamic and selective HERV RNA expression in neuroblastoma cells subjected to variation in oxygen tension and demethylation by Hu, Lijuan, Uzhameckis, Dmitrijs, Hedborg, Fredrik, Blomberg, Jonas

“…We studied HERV expression in cell lines after hypoxia, mitogenic stimulation, and demethylation, to better understand if hypoxia may play a role in ERV…”
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Weekly vinblastine is a therapeutic option in recurrent/refractory pediatric low-grade gliomas by Ehrstedt, Christoffer, Laurencikas, Evaldas, Björklund, Ann-Christin, Strömberg, Bo, Hedborg, Fredrik, Pfeifer, Susan

“…BACKGROUND: In a majority of cases efficient treatment of low-grade gliomas in the pediatric population is achieved by surgery, sometimes accompanied by…”
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Emergence of new ALK mutations at relapse of neuroblastoma by Schleiermacher, Gudrun, Javanmardi, Niloufar, Bernard, Virginie, Leroy, Quentin, Cappo, Julie, Rio-Frio, Thomas, Pierron, Gaëlle, Combaret, Valérie, Speleman, Frank, Djos, Anna, Ora, Ingrid, Hedborg, Fredrik, Holmqvist, Britt-Marie, Abrahamsson, Jonas, Peuchmaur, Michel, Michon, Jean, Janoueix-Lerosey, Isabelle, Kogner, Per, Delattre, Olivier, Martinsson, Tommy

“…Abstract only…”
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The Risk-Associated Long Noncoding RNA NBAT-1Controls Neuroblastoma Progression by RegulatingCell Proliferation and Neuronal Differentiation by Kumar Pandey, Gaurav, Mitra, Sanhita, Subhash, Santhilal, Hertwig, Falk, Kanduri, Meena, Mishra, Kankadeb, Fransson, Susanne, Ganeshram, Abiarchana, Mondal, Tanmoy, Bandaru, Sashidhar, Östensson, Malin, Akyürek, Levent M., Abrahamsson, Jonas, Pfeifer, Susan, Larsson, Erik, Shi, Leming, Peng, Zhiyu, Fischer, Matthias, Martinsson, Tommy, Hedborg, Fredrik, Kogner, Per, Kanduri, Chandrasekhar

“…Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptonnes of…”
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Age dependence of tumor genetics in unfavorable neuroblastoma: arrayCGH profiles of 34 consecutive cases, using a Swedish 25-year neuroblastoma cohort for validation by Cetinkaya, Cihan, Martinsson, Tommy, Sandgren, Johanna, Träger, Catarina, Kogner, Per, Dumanski, Jan, Díaz de Ståhl, Teresita, Hedborg, Fredrik

“…Aggressive neuroblastoma remains a significant cause of childhood cancer death despite current intensive multimodal treatment protocols. The purpose of the…”
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Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment by Brodeur, G M, Pritchard, J, Berthold, F, Carlsen, N L, Castel, V, Castelberry, R P, De Bernardi, B, Evans, A E, Favrot, M, Hedborg, F

“…Based on preliminary experience, there was a need for modifications and clarifications in the International Neuroblastoma Staging System (INSS) and…”
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Nuclear receptor binding protein 2 is induced during neural progenitor differentiation and affects cell survival by Larsson, J., Forsberg, M., Brännvall, K., Zhang, X.-Q., Enarsson, M., Hedborg, F., Forsberg-Nilsson, K.

“…We previously identified nuclear receptor binding protein 2 (NRBP2) in a screen for genes induced by differentiation of neural stem/progenitor cells. Here we…”
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DIFFERENCES IN BIOLOGICAL FEATURES AND SURVIVAL IMPROVEMENT BETWEEN GENETIC SUBSETS OF HIGH-RISK NEUROBLASTOMA INDICATE THE NEED OF ADAPTED TREATMENT by Trager, Catarina, Vernby, Åsa, Caren, Helena, Kryh, Hanna, Martinsson, Tommy, Hedborg, Fredrik, Gustafsson, Göran, Kogner, Per

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AGE-DEPENDENT GENOTYPES IN HIGH-RISK NEUROBLASTOMA: MYCN AMPLIFICATION IS A FAST TRACK TO AGGRESSIVE DISEASE WHEREAS SEGMENTAL DELETION OF 11Q IMPLIES A MORE COMPLEX, MULTI-STEP TUMOR EVOLUTION by Hedborg, Fredrik, Cetinkaya, Cihan, Martinsson, Tommy, Kogner, Per, Dumanski, Jan, Trager, Catarina, de Stahl, Teresita Diaz

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A developmental model of neuroblastoma: differentiating stroma-poor tumors' progress along an extra-adrenal chromaffin lineage by Hoehner, J C, Gestblom, C, Hedborg, F, Sandstedt, B, Olsen, L, Påhlman, S

“…The prognosis of children with neuroblastoma (NB) is dependent upon the patient's age at diagnosis, the location of the primary tumor, and histologic tumor…”
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IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome by Ohlsson, Rolf, Nyström, Anders, Pfeifer-Ohlsson, Susan, Töhönen, Virpi, Hedborg, Fredrik, Schofield, Paul, Flam, Folke, Ekström, Tomas J

“…The phenomenon of parental imprinting involves the preferential expression of one parental allele of a subset of chromosomal genes and has so far only been…”
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Deletion of chromosome 1p loci and microsatellite instability in neuroblastomas analyzed with short-tandem repeat polymorphisms by MARTINSSON, L, SJÖBERG, R.-M, HEDBORG, F, KOGNER, P

“…We have analyzed DNA from 46 neuroblastoma tumors of all clinical stages and five ganglioneuroma tumors together with corresponding control DNA for loss of…”
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Overlapping patterns of IGF2 and H19 expression during human development: biallelic IGF2 expression correlates with a lack of H19 expression by OHLSSON, R, HEDBORG, F, HOLMGREN, L, WALSH, C, EKSTRÖM, T. J

“…The spatial patterns of IGF2 and H19 gene expression are strikingly similar during parts of human embryonic/fetal and early postnatal development. Notable…”
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Evidence for hypoxia‐induced neuronal‐to‐chromaffin metaplasia in neuroblastoma by Hedborg, Fredrik, Ullerås, Erik, Grimelius, Lars, Wassberg, Erik, Maxwell, Patrick H, Hero, Barbara, Berthold, Frank, Schilling, Freimut, Harms, Dieter, Sandstedt, Bengt, Franklin, Gary

“…ABSTRACT We present evidence that in neuroblastoma, a pediatric malignancy of embryonal sympathetic origin, hypoxia, underlies a phenotypic switch from a…”
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Developmental gene expression of sympathetic nervous system tumors reflects their histogenesis by Hoehner, J C, Hedborg, F, Eriksson, L, Sandstedt, B, Grimelius, L, Olsen, L, Påhlman, S

“…Comparisons of the developing human sympathetic nervous system (SNS) to tumors presumed to derive from these cells may suggest tumor progenitors and predict…”
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