Search Results - "HEBEISEN, P"

Early preclinical development of PQR309, a novel balanced dual PI3K/mTOR inhibitor for treatment of various cancer types by Ettlin, R., Dieterle, W., Fabbro, D., Hebeisen, P., Beaufils, F., Hillmann, P., Stumm, M., Dimitrijević, S., Wymann, M., Cmiljanovic, N., Giese, B., Cmiljanovic, V.

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In Vitro and In Vivo Properties of Ro 63-9141, a Novel Broad-Spectrum Cephalosporin with Activity against Methicillin-Resistant Staphylococci by HEBEISEN, Paul, HEINZE-KRAUSS, Ingrid, ANGEHRN, Peter, HOHL, Peter, PAGE, Malcolm G. P, THEN, Rudolf L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2 -a]pyrazines as potent and selective 5-HT2C receptor agonists by RICHTER, Hans G. F, ADAMS, D. R, KNIGHT, A. R, MALCOLM, C. S, MATTEI, P, MISRA, A, MIZRAHI, J, MONCK, N. J. T, PLANCHER, J.-M, ROEVER, S, ROFFEY, J. R. A, TAYLOR, S, BENARDEAU, A, VICKERS, S. P, BICKERDIKE, M. J, BENTLEY, J. M, BLENCH, T. J, CLIFFE, I. A, DOURISH, C, HEBEISEN, P, KENNETT, G. A

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Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists by RÖVER, S, ADAMS, D. R, HEBEISEN, P, KENNETT, G. A, KNIGHT, A. R, MALCOLM, C. S, MATTEI, P, MISRA, A, MIZRAHI, J, MULLER, M, PORTER, R. H. P, RICHTER, H, BENARDEAU, A, TAYLOR, S, VICKERS, S. P, BENTLEY, J. M, BICKERDIKE, M. J, BOURSON, A, CLIFFE, I. A, COASSOLO, P, DAVIDSON, J. E. P, DOURISH, C. T

“…Synthesis and evaluation of the activity of new 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT(2C) receptor agonists are described…”
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Cyclothialidine and its congeners: a new class of DNA gyrase inhibitors by Goetschi, E, Angehrn, P, Gmuender, H, Hebeisen, P, Link, H, Masciadri, R, Nielsen, J

“…Cyclothialidine is a new, potent DNA gyrase inhibitor isolated from Streptomyces filipinensis. However, it exhibits hardly any growth-inhibitory activity…”
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New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine by Angehrn, Peter, Buchmann, Stefan, Funk, Christoph, Goetschi, Erwin, Gmuender, Hans, Hebeisen, Paul, Kostrewa, Dirk, Link, Helmut, Luebbers, Thomas, Masciadri, Raffaello, Nielsen, Joergen, Reindl, Peter, Ricklin, Fabienne, Schmitt-Hoffmann, Anne, Theil, Frank-Peter

“…Cyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensis NR0484 and is a member of a new family of…”
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Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists by Richter, Hans G F, Adams, D R, Benardeau, A, Bickerdike, M J, Bentley, J M, Blench, T J, Cliffe, I A, Dourish, C, Hebeisen, P, Kennett, G A, Knight, A R, Malcolm, C S, Mattei, P, Misra, A, Mizrahi, J, Monck, N J T, Plancher, J-M, Roever, S, Roffey, J R A, Taylor, S, Vickers, S P

“…Further lead optimization efforts on previously described 1,2,3,4,10,10a-hexahydro-1H-pyrazino[1,2-a]indoles led to the new class of…”
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Synthesis and biological evaluation of novel hexahydro- pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT sub(2C) receptor agonists by Richter, Hans GF, Adams, DR, Benardeau, A, Bickerdike, MJ, Bentley, J M, Blench, T J, Cliffe, IA, Dourish, C, Hebeisen, P, Kennett, G A, Knight, A R, Malcolm, C S, Mattei, P, Misra, A, Mizrahi, J, Monck, NJT, Plancher, J-M, Roever, S, Roffey, JRA, Taylor, S, Vickers, S P

“…Further lead optimization efforts on previously described 1,2,3,4,10,10a- hexahydro-1H-pyrazino[1,2-a]indoles led to the new class of…”
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Synthesis and biological evaluation of novel hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2- a]pyrazines as potent and selective 5-HT 2C receptor agonists by Richter, Hans G.F., Adams, D.R., Benardeau, A., Bickerdike, M.J., Bentley, J.M., Blench, T.J., Cliffe, I.A., Dourish, C., Hebeisen, P., Kennett, G.A., Knight, A.R., Malcolm, C.S., Mattei, P., Misra, A., Mizrahi, J., Monck, N.J.T., Plancher, J.-M., Roever, S., Roffey, J.R.A., Taylor, S., Vickers, S.P.

“…A novel series of chiral 5,5a,6,7,8,9-hexahydro-9-methyl-pyrido[3′,2′:4,5]pyrrolo[1,2- a]pyrazines as potent and selective 5-HT 2C receptor agonists has been…”
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Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2- a]indoles as 5-HT 2C receptor agonists by Röver, S., Adams, D.R., Bénardeau, A., Bentley, J.M., Bickerdike, M.J., Bourson, A., Cliffe, I.A., Coassolo, P., Davidson, J.E.P., Dourish, C.T., Hebeisen, P., Kennett, G.A., Knight, A.R., Malcolm, C.S., Mattei, P., Misra, A., Mizrahi, J., Muller, M., Porter, R.H.P., Richter, H., Taylor, S., Vickers, S.P.

“…New 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2- a]indoles are 5-HT 2C receptor agonists. Appropriately substituted, several analogs show high potency and…”
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5-HT2C Receptor Agonists for the Treatment of Obesity. Biological and Chemical Adventures by David Adams, Sven Taylor, Stephan Röver, Hans Richter, Jean-Marc Plancher, Jacques Mizrahi, Craig S. Malcolm, Antony R. Knight, Guy A. Kennett, Paul Hebeisen, Ian A. Cliffe, Anne Bourson, Caterina Bissantz, Jon M. Bentley, Mike J. Bickerdike, Agnès Bénardeau, Steven P. Vickers

“…Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease and cancer. There is…”
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From the DNA Gyrase Inhibitor Cyclothialidine to a New Class of Antibacterial Agents by Erwin Goetschi, Fabienne Ricklin, Peter Reindl, Raffaello Masciadri, Thomas Luebbers, Helmut Link, Dirk Kostrewa, Paul Hebeisen, Hans Gmuender, Peter Angehrn, Frank-Peter Theil

“…Cyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from S. filipinensis NR0484. In this account we describe the identification of…”
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Synthesis and Structure−Activity Relationship of (Lactamylvinyl)cephalosporins Exhibiting Activity against Staphylococci, Pneumococci, and Enterococci by Heinze-Krauss, Ingrid, Angehrn, Peter, Guerry, Philippe, Hebeisen, Paul, Hubschwerlen, Christian, Kompis, Ivan, Page, Malcolm G. P, Richter, Hans G. F, Runtz, Valérie, Stalder, Henri, Weiss, Urs, Wei, Chung-Chen

“…The synthesis and structure−activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue (1) are described. These compounds…”
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Synthesis of bicyclic keto silanes by tandem rearrangement of silylacetylenic ketones by Kende, Andrew S, Hebeisen, Paul, Newbold, Ronald C

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Structure of an unusual 1:2 carbene-methacrylonitrile adduct. Chemical evidence for nitrile ylide formation by Kende, Andrew S, Hebeisen, Paul, Sanfilippo, Pauline J, Toder, Bruce H

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