Search Results - "HEBBAR, Vidya"

Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals by Chen, Chi, Pung, Daniel, Leong, Vasco, Hebbar, Vidya, Shen, Guoxiang, Nair, Sujit, Li, Wenge, Tony Kong, A.-N.

“…Garlic organosulfur compounds (OSCs) are recognized as a group of potential chemopreventive compounds. It is known that garlic OSCs can modulate drug…”
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Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats by Barve, Avantika, Chen, Chi, Hebbar, Vidya, Desiderio, Joseph, Saw, Constance Lay-Lay, Kong, Ah-Ng

“…The purpose of this study was to compare the hepatic and small intestinal metabolism, and to examine bioavailability and gastro‐intestinal first‐pass effects,…”
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In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat by Hu, Rong, Hebbar, Vidya, Kim, Bok-Ryang, Chen, Chi, Winnik, Bozena, Buckley, Brian, Soteropoulos, Patricia, Tolias, Peter, Hart, Ronald P, Kong, A-N Tony

“…Sulforaphane (SUL) is one member of the isothiocyanate class of cancer chemopreventive compounds that has been shown to be effective in blocking initiation and…”
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Synergistic Effects of a Combination of Dietary Factors Sulforaphane and (−) Epigallocatechin-3-gallate in HT-29 AP-1 Human Colon Carcinoma Cells by Nair, Sujit, Hebbar, Vidya, Shen, Guoxiang, Gopalakrishnan, Avantika, Khor, Tin Oo, Yu, Siwang, Xu, Changjiang, Kong, Ah-Ng

“…Purpose The objective of this study was to investigate combinations of two chemopreventive dietary factors: EGCG 20 μM (or 100 μM) and SFN (25 μM) in HT-29…”
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Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism by Yu, Rong, Chen, Chi, Mo, Yin-Yuan, Hebbar, Vidya, Owuor, Edward D., Tan, Tse-Hua, Kong, A.-N. Tony

“…Antioxidant response element (ARE) regulates the induction of a number of cellular antioxidant and detoxifying enzymes. However, the signaling pathways that…”
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Nrf2 Possesses a Redox-insensitive Nuclear Export Signal Overlapping with the Leucine Zipper Motif by Li, Wenge, Jain, Mohit R, Chen, Chi, Yue, Xin, Hebbar, Vidya, Zhou, Renping, Kong, A-N Tony

“…Basic leucine zipper (bZIP) protein Nrf2 is a key transcription factor mediating the antioxidant response. Under homeostatic conditions Nrf2 is anchored to…”
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Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE) by Kong, A.-N. Tony, Owuor, Edward, Yu, Rong, Hebbar, Vidya, Chen, Chi, Hu, Rong, Mandlekar, Sandhya

“…Cellular responses to xenobiotic-induced stress can signal proliferation, differentiation, homeostasis, apoptosis, or necrosis. To better understand the…”
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Signal transduction events elicited by cancer prevention compounds by Kong, A N, Yu, R, Hebbar, V, Chen, C, Owuor, E, Hu, R, Ee, R, Mandlekar, S

“…Many chemopreventive agents have been shown to modulate gene expression including induction of phase II detoxifying enzymes, such as glutathione S-transferases…”
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Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways by Yu, R, Hebbar, V, Kim, D W, Mandlekar, S, Pezzuto, J M, Kong, A N

“…Resveratrol, a phenolic compound found in grapes and other food products, prevents chemical-induced carcinogenesis in a number of animal models of cancers. To…”
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Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice by Nair, Sujit, Xu, Changjiang, Shen, Guoxiang, Hebbar, Vidya, Gopalakrishnan, Avantika, Hu, Rong, Jain, Mohit Raja, Lin, Wen, Keum, Young-Sam, Liew, Celine, Chan, Jefferson Y, Kong, Ah-Ng Tony

“…The objective of this study was to investigate the pharmacogenomics and the spatial regulation of global gene expression profiles elicited by cancer…”
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Differential expression of MUC genes in endometrial and cervical tissues and tumors by Hebbar, Vidya, Damera, Gautam, Sachdev, Goverdhan P

“…Mucin glycoprotein's are major components of mucus and are considered an important class of tumor associated antigens. The objective of this study was to…”
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Effects of 12-O-Tetradecanoylphorbol-13-acetate (TPA) in Combination with Paclitaxel (Taxol) on Prostate Cancer LNCaP Cells Cultured In vitro or Grown as Xenograft Tumors in Immunodeficient Mice by XI ZHENG, CHANG, Richard L, KONG, Ah Ng Tony, CONNEY, Allan H, CUI, Xiao-Xing, AVILA, Gina E, HEBBAR, Vidya, GARZOTTO, Mark, SHIH, Weichung Joe, YONG LIN, LU, Shou-En, RABSON, Arnold B

“…Purpose: To investigate the effects of 12- O -tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate cancer cells cultured in…”
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Regulation of Nrf2 Transactivation Domain Activity by Shen, Guoxiang, Hebbar, Vidya, Nair, Sujit, Xu, Changjiang, Li, Wenge, Lin, Wen, Keum, Young-Sam, Han, Jiahuai, Gallo, Michael A., Kong, A.-N. Tony

“…Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of Phase II detoxifying enzymes as well as anti-oxidative enzymes. In this study, we…”
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Modulation of Activator Protein-1 (AP-1) and MAPK Pathway by Flavonoids in Human Prostate Cancer PC3 Cells by Gopalakrishnan, Avanthika, Xu, Chang-Jiang, Nair, Sujit S, Chen, Chi, Hebbar, Vidya, Kong, Ah-Ng Tony

“…In last couple of decades the use of natural compounds like flavonoids as chemopreventive agents has gained much attention. Our current study focuses on…”
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Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable by Hu, Rong, Khor, Tin Oo, Shen, Guoxiang, Jeong, Woo-Sik, Hebbar, Vidya, Chen, Chi, Xu, Changjiang, Reddy, Bandaru, Chada, Kiran, Kong, Ah-Ng Tony

“…Sulforaphane (SFN) is an isothiocyanate that is present abundantly in widely consumed cruciferous vegetables and has a particularly high content in broccoli…”
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p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1 by GUOXIANG SHEN, CHANGJIANG XU, CHI CHEN, HEBBAR, Vidya, KONG, Ah-Ng Tony

“…Isothiocyanate sulforaphane (SFN) is a potent cancer chemopreventive agent. We investigated the mechanisms underlying the anti-proliferative effects of SFN in…”
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Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells by Chen, Chi, Shen, Guoxiang, Hebbar, Vidya, Hu, Rong, Owuor, Edward D., Kong, A.-N.Tony

“…Epigallocatechin-3-gallate (EGCG), a major component in green tea polyphenols, has been proven to suppress colonic tumorigenesis in animal models and…”
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Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein by Shen, Guoxiang, Hebbar, Vidya, Nair, Sujit, Xu, Changjiang, Li, Wenge, Lin, Wen, Keum, Young-Sam, Han, Jiahuai, Gallo, Michael A, Kong, A-N Tony

“…Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of Phase II detoxifying enzymes as well as anti-oxidative enzymes. In this study, we…”
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Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane by KIM, Bok-Ryang, HU, Rong, KEUM, Young-Sam, HEBBAR, Vidya, SHEN, Guoxiang, NAIR, Sujit S, KONG, A.-N. Tony

“…Sulforaphane (SFN) and its N-acetyl-L-cysteine (NAC) conjugate are effective inhibitors of tumorigenesis in animal models. These compounds induce the…”
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The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells by Hu, Rong, Kim, Bok Ryang, Chen, Chi, Hebbar, Vidya, Kong, A.-N.Tony

“…Phenethyl isothiocyanate (PEITC) is a potential chemopreventive agent that is present naturally in widely consumed vegetables, especially in watercress. It has…”
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