Search Results - "HEBBAR, Sudarshan"

Auxora versus standard of care for the treatment of severe or critical COVID-19 pneumonia: results from a randomized controlled trial by Miller, Joseph, Bruen, Charles, Schnaus, Michael, Zhang, Jeffrey, Ali, Sadia, Lind, April, Stoecker, Zachary, Stauderman, Kenneth, Hebbar, Sudarshan

“…Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially…”
Get full text

Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial by Bruen, Charles, Al-Saadi, Mukhtar, Michelson, Edward A, Tanios, Maged, Mendoza-Ayala, Raul, Miller, Joseph, Zhang, Jeffrey, Stauderman, Kenneth, Hebbar, Sudarshan, Hou, Peter C

“…Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat…”
Get full text

Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney by REISMAN, Scott A, CHERTOW, Glenn M, HEBBAR, Sudarshan, VAZIRI, Nosratola D, WARD, Keith W, MEYER, Colin J

“…Inflammation and oxidative stress are hallmarks and mediators of the progression of CKD. Bardoxolone methyl, a potent activator of the nuclear factor erythroid…”
Get full text

Derivation and validation of the ED-SAS score for very early prediction of mortality and morbidity with acute pancreatitis: a retrospective observational study by Miller, Joseph, Wu, Yiyang, Safa, Rawan, Marusca, Georgiana, Bhatti, Sandeep, Ahluwalia, Guneet, Dandashi, Jad, Acevedo, Harold Gomez, Farook, Naureen, Scott, Ashley, Nair, Vidhya, Adhami, Angie, Dueweke, Jeffrey, Hebbar, Sudarshan, Ekstrom, Leeland

“…Existing scoring systems to predict mortality in acute pancreatitis may not be directly applicable to the emergency department (ED). The objective of this…”
Get full text

Orai1 calcium channel inhibition prevents progression of chronic pancreatitis by Szabó, Viktória, Csákány-Papp, Noémi, Görög, Marietta, Madácsy, Tamara, Varga, Árpád, Kiss, Aletta, Tél, Bálint, Jójárt, Boldizsár, Crul, Tim, Dudás, Krisztina, Bagyánszki, Mária, Bódi, Nikolett, Ayaydin, Ferhan, Jee, Shyam, Tiszlavicz, László, Stauderman, Kenneth A, Hebbar, Sudarshan, Pallagi, Petra, Maléth, József

“…Patients with recurrent acute pancreatitis (RAP) are at significant risk of developing early chronic pancreatitis (CP), which progresses into irreversible,…”
Get full text

Distinguishing benign from malignant pelvic mass utilizing an algorithm with HE4, menopausal status, and ultrasound findings by Wilailak, Sarikapan, Chan, Karen K L, Chen, Chi An, Nam, Joo Hyun, Ochiai, Kazunori, Aw, Tar Choon, Sabaratnam, Subathra, Hebbar, Sudarshan, Sickan, Jaganathan, Schodin, Beth A, Charakorn, Chuenkamon, Sumpaico, Walfrido W

“…The purpose of this study was to develop a risk prediction score for distinguishing benign ovarian mass from malignant tumors using CA-125, human epididymis…”
Get full text

Diagnostic and Prognostic Stratification in the Emergency Department Using Urinary Biomarkers of Nephron Damage by Nickolas, Thomas L., MD, MS, Schmidt-Ott, Kai M., MD, Canetta, Pietro, MD, Forster, Catherine, MD, Singer, Eugenia, MD, Sise, Meghan, MD, Elger, Antje, MD, Maarouf, Omar, MD, Sola-Del Valle, David Antonio, MD, O'Rourke, Matthew, MD, Sherman, Evan, MD, Lee, Peter, BS, Geara, Abdallah, MD, Imus, Philip, MD, Guddati, Achuta, MD, Polland, Allison, MD, Rahman, Wasiq, MD, Elitok, Saban, MD, Malik, Nasir, MD, Giglio, James, MD, El-Sayegh, Suzanne, MD, Devarajan, Prasad, MD, Hebbar, Sudarshan, MD, Saggi, Subodh J., MD, Hahn, Barry, MD, Kettritz, Ralph, MD, Luft, Friedrich C., MD, Barasch, Jonathan, MD, PhD

“…Objectives This study aimed to determine the diagnostic and prognostic value of urinary biomarkers of intrinsic acute kidney injury (AKI) when patients were…”
Get full text

Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome: Clinical Development of a Calcium Release-Activated Calcium Channel Inhibitor by Bruen, Charles, Miller, Joseph, Wilburn, John, Mackey, Caleb, Bollen, Thomas L., Stauderman, Kenneth, Hebbar, Sudarshan

“…To assess the safety of Auxora in patients with acute pancreatitis (AP), systemic inflammatory response syndrome (SIRS), and hypoxemia, and identify efficacy…”
Get full text

Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome: Clinical Development of a Calcium Release-Activated Calcium Channel Inhibitor by Bruen, Charles, Miller, Joseph, Wilburn, John, Mackey, Caleb, Bollen, Thomas L., Stauderman, Kenneth, Hebbar, Sudarshan

“…To assess the safety of Auxora in patients with acute pancreatitis (AP), systemic inflammatory response syndrome (SIRS), and hypoxemia, and identify efficacy…”
Get full text

Sa1468 SERUM PROTEOMICS REVEALS THAT THE ORAI1 INHIBITOR AUXORA MAY PROVIDE BENEFITS IN SEVERE ACUTE PANCREATITIS SIMILAR TO THOSE SEEN IN COVID-19 PNEUMONIA by Waldron, Richard T., Lugea, Aurelia, Ayres, Matthew, Parker, Sarah J., Van Eyk, Jennifer, Hebbar, Sudarshan, Stauderman, Kenneth A., Pandol, Stephen J.

Get full text

Diagnostic and Prognostic Stratification in the Emergency Department Using Urinary Biomarkers of Nephron Damage: A Multicenter Prospective Cohort Study by NICKOLAS, Thomas L, SCHMIDT-OTT, Kai M, SHERMAN, Evan, LEE, Peter, GEARA, Abdallah, IMUS, Philip, GUDDATI, Achuta, POLLAND, Allison, RAHMAN, Wasiq, ELITOK, Saban, MALIK, Nasir, GIGLIO, James, CANETTA, Pietro, EL-SAYEGH, Suzanne, DEVARAJAN, Prasad, HEBBAR, Sudarshan, SAGGI, Subodh J, HAHN, Barry, KETTRITZ, Ralph, LUFT, Friedrich C, BARASCH, Jonathan, FORSTER, Catherine, SINGER, Eugenia, SISE, Meghan, ELGER, Antje, MAAROUF, Omar, SOLA-DEL VALLE, David Antonio, O'ROURKE, Matthew

“…This study aimed to determine the diagnostic and prognostic value of urinary biomarkers of intrinsic acute kidney injury (AKI) when patients were triaged in…”
Get full text

294: Auxora Improves D-Dimer Levels in Patients With Severe COVID-19 Pneumonia by Bruen, Charles, Miller, Joseph, Schnaus, Michael, Zhang, Jeffrey, Ali, Sadia, Lind, April, Stoecker, Zachary, Stauderman, Kenneth, Hebbar, Sudarshan

Get full text

Abstract WP134: Calcium Release-activated Calcium Channel Inhibition Improves Neurological Outcome and Suppresses Inflammation in Female Mice Following Cerebral Ischemic Injury by Mizuma, Atsushi, Kacimi, Rachid, Stauderman, Ken, Dunn, Michael J, Hebbar, Sudarshan, Yenari, Midori A

“…Abstract only Purpose: Calcium release-activated calcium (CRAC) channels activate microglia via store-operated Ca 2+ entry. We previously reported that the…”
Get full text

Abstract TP255: Calcium Release-activated Calcium Channel Inhibition Protects Against Inflammation in Ischemic Stroke by Mizuma, Atsushi, Kacimi, Rachid, Stauderman, Ken, Dunn, Michael J, Hebbar, Sudarshan, Yenari, Midori A

“…Abstract only Purpose: Inflammatory responses after ischemic stroke contribute to worsening of ischemic brain injury. Calcium release-activated calcium (CRAC)…”
Get full text

475: EMERGENCY DEPARTMENT SPO2, AGE, AND SIRS (ED-SAS) SCORE PREDICTS MORTALITY IN ACUTE PANCREATITIS by Ahluwalia, Guneet, Wu, Yiyang, Gomez, Harold, Farook, Naureen, Scott, Ashley, Nair, Vidhya, Mohammed, Hadi, Dueweke, Jeffrey, Adhami, Angie, Hebbar, Sudarshan, Miller, Joseph

Get full text

Orai1 calcium channel inhibition prevents progression of chronic pancreatitis by Szabó, Viktória, Csákány-Papp, Noémi, Görög, Marietta, Madácsy, Tamara, Varga, Árpád, Kiss, Aletta, Tél, Bálint, Jójárt, Boldizsár, Crul, Tim, Dudás, Krisztina, Bagyánszki, Mária, Bódi, Nikolett, Ayaydin, Ferhan, Jee, Shyam, Tiszlavicz, László, Stauderman, Kenneth, Hebbar, Sudarshan, Pallagi, Petra, Maléth, József

Get full text

Abstract TP272: Calcium Release-activated Calcium (CRAC) Channel Inhibition Protects Against Brain Injury and Neuronal Death Induced by Activated Microglia by Kacimi, Rachid, Kim, Jong Youl, Stauderman, Ken, Dunn, Michael, Hebbar, Sudarshan, Yenari, Midori A

“…Abstract only Inflammatory responses following ischemia can worsen neurological outcome, and represent a potential target for therapeutic intervention…”
Get full text

The use of HE4 in the prediction of ovarian cancer in Asian women with a pelvic mass by Chan, Karen K.L, Chen, Chi-An, Nam, Joo-Hyun, Ochiai, Kazunori, Wilailak, Sarikapan, Choon, Aw-Tar, Sabaratnam, Subathra, Hebbar, Sudarshan, Sickan, Jaganathan, Schodin, Beth A, Sumpaico, Walfrido W

“…Abstract Objective The purpose of this study was to evaluate the performance of human epididymis protein 4 (HE4) and the Risk of Ovarian Malignancy Algorithm…”
Get full text

Medication prescribing patterns in ambulatory haemodialysis patients: comparisons of USRDS to a large not-for-profit dialysis provider by Manley, Harold J., Garvin, Cory G., Drayer, Debra K., Reid, Gerald M., Bender, Walter L., Neufeld, Timothy K., Hebbar, Sudarshan, Muther, Richard S.

“…Background. End-stage renal disease (ESRD) patients are prescribed numerous medications. The United States Renal Data System (USRDS) reported on medication…”
Get full text

Adverse drug reaction driven immunosuppressive drug manipulations: a single-center comparison of enteric-coated mycophenolate sodium vs. mycophenolate mofetil by Hardinger, Karen L., Hebbar, Sudarshan, Bloomer, Terry, Murillo, Daniel

“…:  Enteric‐coated mycophenolate sodium (MPS) has been developed to help circumvent the upper gastrointestinal side‐effects of mycophenolic acid by facilitating…”
Get full text