Search Results - "HEATH, Simon"

Distinct DNA methylomes of newborns and centenarians by Heyn, Holger, Li, Ning, Ferreira, Humberto J., Moran, Sebastian, Pisano, David G., Gomez, Antonio, Diez, Javier, Sanchez-Mut, Jose V., Setien, Fernando, Carmona, F. Javier, Puca, Annibale A., Sayols, Sergi, Pujana, Miguel A., Serra-Musach, Jordi, Iglesias-Platas, Isabel, Formiga, Francesc, Fernandez, Agustin F., Fraga, Mario F., Heath, Simon C., Valencia, Alfonso, Gut, Ivo G., Wang, Jun, Esteller, Manel

“…Human aging cannot be fully understood in terms of the constrained genetic setting. Epigenetic drift is an alternative means of explaining age-associated…”
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Impact of DNA methylation on 3D genome structure by Buitrago, Diana, Labrador, Mireia, Arcon, Juan Pablo, Lema, Rafael, Flores, Oscar, Esteve-Codina, Anna, Blanc, Julie, Villegas, Nuria, Bellido, David, Gut, Marta, Dans, Pablo D., Heath, Simon C., Gut, Ivo G., Brun Heath, Isabelle, Orozco, Modesto

“…Determining the effect of DNA methylation on chromatin structure and function in higher organisms is challenging due to the extreme complexity of epigenetic…”
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Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate by Sardina, Jose Luis, Collombet, Samuel, Tian, Tian V., Gómez, Antonio, Di Stefano, Bruno, Berenguer, Clara, Brumbaugh, Justin, Stadhouders, Ralph, Segura-Morales, Carolina, Gut, Marta, Gut, Ivo G., Heath, Simon, Aranda, Sergi, Di Croce, Luciano, Hochedlinger, Konrad, Thieffry, Denis, Graf, Thomas

“…Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution using C/EBPα-enhanced reprogramming of B cells into induced…”
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Selective single molecule sequencing and assembly of a human Y chromosome of African origin by Kuderna, Lukas F. K., Lizano, Esther, Julià, Eva, Gomez-Garrido, Jessica, Serres-Armero, Aitor, Kuhlwilm, Martin, Alandes, Regina Antoni, Alvarez-Estape, Marina, Juan, David, Simon, Heath, Alioto, Tyler, Gut, Marta, Gut, Ivo, Schierup, Mikkel Heide, Fornas, Oscar, Marques-Bonet, Tomas

“…Mammalian Y chromosomes are often neglected from genomic analysis. Due to their inherent assembly difficulties, high repeat content, and large ampliconic…”
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gemBS: high throughput processing for DNA methylation data from bisulfite sequencing by Merkel, Angelika, Fernández-Callejo, Marcos, Casals, Eloi, Marco-Sola, Santiago, Schuyler, Ronald, Gut, Ivo G, Heath, Simon C

“…Abstract Motivation DNA methylation is essential for normal embryogenesis and development in mammals and can be captured at single base pair resolution by…”
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Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease by Clarke, Robert, Peden, John F, Hopewell, Jemma C, Kyriakou, Theodosios, Goel, Anuj, Heath, Simon C, Parish, Sarah, Barlera, Simona, Franzosi, Maria Grazia, Rust, Stephan, Bennett, Derrick, Silveira, Angela, Malarstig, Anders, Green, Fiona R, Lathrop, Mark, Gigante, Bruna, Leander, Karin, de Faire, Ulf, Seedorf, Udo, Hamsten, Anders, Collins, Rory, Watkins, Hugh, Farrall, Martin

“…Using a novel gene chip, investigators identified single-nucleotide polymorphisms (SNPs) from three chromosomal regions, including the LPA locus, that were…”
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Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time by Feichtinger, Julia, Hernández, Inmaculada, Fischer, Christoph, Hanscho, Michael, Auer, Norbert, Hackl, Matthias, Jadhav, Vaibhav, Baumann, Martina, Krempl, Peter M., Schmidl, Christian, Farlik, Matthias, Schuster, Michael, Merkel, Angelika, Sommer, Andreas, Heath, Simon, Rico, Daniel, Bock, Christoph, Thallinger, Gerhard G., Borth, Nicole

“…ABSTRACT The most striking characteristic of CHO cells is their adaptability, which enables efficient production of proteins as well as growth under a variety…”
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Tuning of Natural Killer Cell Reactivity by NKp46 and Helios Calibrates T Cell Responses by Narni-Mancinelli, Emilie, Jaeger, Baptiste N., Bernat, Claire, Fenis, Aurore, Kung, Sam, De Gassart, Aude, Mahmood, Sajid, Gut, Marta, Heath, Simon C., Estellé, Jordi, Bertosio, Elodie, Vely, Frédéric, Gastinel, Louis N., Beutler, Bruce, Malissen, Bernard, Malissen, Marie, Gut, Ivo G., Vivier, Eric, Ugolini, Sophie

“…Natural killer (NK) cells are lymphocytes involved in antimicrobial and antitumoral immune responses. Using N-ethyl-N-nitrosourea mutagenesis in mice, we…”
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PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8 + T lymphocytes by Ogando, Jesús, Sáez, María Eugenia, Santos, Javier, Nuevo-Tapioles, Cristina, Gut, Marta, Esteve-Codina, Anna, Heath, Simon, González-Pérez, Antonio, Cuezva, José M, Lacalle, Rosa Ana, Mañes, Santos

“…Binding of the programmed death-1 (PD-1) receptor to its ligands (PD-L1/2) transduces inhibitory signals that promote exhaustion of activated T cells. Blockade…”
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A Comparison of RNA-Seq Results from Paired Formalin-Fixed Paraffin-Embedded and Fresh-Frozen Glioblastoma Tissue Samples by Esteve-Codina, Anna, Arpi, Oriol, Martinez-García, Maria, Pineda, Estela, Mallo, Mar, Gut, Marta, Carrato, Cristina, Rovira, Anna, Lopez, Raquel, Tortosa, Avelina, Dabad, Marc, Del Barco, Sonia, Heath, Simon, Bagué, Silvia, Ribalta, Teresa, Alameda, Francesc, de la Iglesia, Nuria, Balaña, Carmen

“…The molecular classification of glioblastoma (GBM) based on gene expression might better explain outcome and response to treatment than clinical factors. Whole…”
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A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15 by Heath, Simon, Rooks, Helen, Thein, Swee Lay, Lathrop, Mark, Farrall, Martin, Yamaguchi, Masao, Garner, Chad, Best, Steve, Gut, Ivo, Matsuda, Fumihiko, Menzel, Stephan, Foglio, Mario, Zelenika, Diana, Boland, Anne, Spector, Tim D

“…F cells measure the presence of fetal hemoglobin, a heritable quantitative trait in adults that accounts for substantial phenotypic diversity of sickle cell…”
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Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate by Sardina, Jose Luis, Collombet, Samuel, Tian, Tian V., Gómez, Antonio, Di Stefano, Bruno, Berenguer, Clara, Brumbaugh, Justin, Stadhouders, Ralph, Segura-Morales, Carolina, Gut, Marta, Gut, Ivo G., Heath, Simon, Aranda, Sergi, Di Croce, Luciano, Hochedlinger, Konrad, Thieffry, Denis, Graf, Thomas

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A note on exact differences between beta distributions in genomic (Methylation) studies by Raineri, Emanuele, Dabad, Marc, Heath, Simon

“…We apply a known algorithm for computing exactly inequalities between Beta distributions to assess whether a given position in a genome is differentially…”
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Information recovery from low coverage whole-genome bisulfite sequencing by Libertini, Emanuele, Heath, Simon C., Hamoudi, Rifat A., Gut, Marta, Ziller, Michael J., Czyz, Agata, Ruotti, Victor, Stunnenberg, Hendrik G., Frontini, Mattia, Ouwehand, Willem H., Meissner, Alexander, Gut, Ivo G., Beck, Stephan

“…The cost of whole-genome bisulfite sequencing (WGBS) remains a bottleneck for many studies and it is therefore imperative to extract as much information as…”
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Genome Response to Artificial Selection: A Case Study in Dairy Cattle by Flori, Laurence, Fritz, Sebastien, Jaffrezic, Florence, Boussaha, Mekki, Gut, Ivo, Heath, Simon, Foulley, Jean-Louis, Gautier, Mathieu

“…Dairy cattle breeds have been subjected over the last fifty years to intense artificial selection towards improvement of milk production traits. In this study,…”
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Novel Breast Cancer Susceptibility Locus at 9q31.2: Results of a Genome-Wide Association Study by FLETCHER, Olivia, JOHNSON, Nichola, COUPLAND, Ben, BRODERICK, Peter, SCHOEMAKER, Minouk, JONES, Michael, WILLIAMSON, Jill, CHILCOTT-BURNS, Sarah, TOMCZYK, Katarzyna, SIMPSON, Gemma, JACOBS, Kevin B, CHANOCK, Stephen J, ORR, Nick, HUNTER, David J, TOMLINSON, Ian P, SWERDLOW, Anthony, ASHWORTH, Alan, ROSS, Gillian, DOS SANTOS SILVA, Isabel, LATHROP, Mark, HOULSTON, Richard S, PETO, Julian, HOSKING, Fay J, GIBSON, Lorna J, WALKER, Kate, ZELENIKA, Diana, GUT, Ivo, HEATH, Simon, PALLES, Claire

“…Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial…”
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Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4 by Libioulle, Cécile, Louis, Edouard, Hansoul, Sarah, Sandor, Cynthia, Farnir, Frédéric, Franchimont, Denis, Vermeire, Séverine, Dewit, Olivier, de Vos, Martine, Dixon, Anna, Demarche, Bruno, Gut, Ivo, Heath, Simon, Foglio, Mario, Liang, Liming, Laukens, Debby, Mni, Myriam, Zelenika, Diana, Van Gossum, André, Rutgeerts, Paul, Belaiche, Jacques, Lathrop, Mark, Georges, Michel

“…To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide association study with more than 300,000 SNPs characterized in 547…”
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Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach by Trégouët, David-Alexandre, Heath, Simon, Saut, Noémie, Biron-Andreani, Christine, Schved, Jean-François, Pernod, Gilles, Galan, Pilar, Drouet, Ludovic, Zelenika, Diana, Juhan-Vague, Irène, Alessi, Marie-Christine, Tiret, Laurence, Lathrop, Mark, Emmerich, Joseph, Morange, Pierre-Emmanuel

“…Venous thromboembolism (VTE) is a complex disease that has a major genetic component of risk. To identify genetic factors that may modify the risk of VTE, we…”
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Mutations of the FHL1 Gene Cause Emery-Dreifuss Muscular Dystrophy by Gueneau, Lucie, Bertrand, Anne T., Jais, Jean-Philippe, Salih, Mustafa A., Stojkovic, Tanya, Wehnert, Manfred, Hoeltzenbein, Maria, Spuler, Simone, Saitoh, Shinji, Verschueren, Annie, Tranchant, Christine, Beuvin, Maud, Lacene, Emmanuelle, Romero, Norma B., Heath, Simon, Zelenika, Diana, Voit, Thomas, Eymard, Bruno, Ben Yaou, Rabah, Bonne, Gisèle

“…Emery-Dreifuss muscular dystrophy (EDMD) is a rare disorder characterized by early joint contractures, muscular dystrophy, and cardiac involvement with…”
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Genetic factors of susceptibility and of severity in primary biliary cirrhosis by Poupon, Raoul, Ping, Chen, Chrétien, Yves, Corpechot, Christophe, Chazouillères, Olivier, Simon, Tabassome, Heath, Simon C, Matsuda, Fumihiko, Poupon, Renée E, Housset, Chantal, Barbu, Véronique

“…Background/Aims In primary biliary cirrhosis (PBC), pathogenesis is influenced by genetic factors that remain poorly elucidated up to now. We investigated the…”
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