Search Results - "HEALY, Zachary R"

Transcriptional Profiling of CD8+ CMV-Specific T Cell Functional Subsets Obtained Using a Modified Method for Isolating High-Quality RNA From Fixed and Permeabilized Cells by Healy, Zachary R, Weinhold, Kent J, Murdoch, David M

“…Previous studies suggest that the presence of antigen-specific polyfunctional T cells is correlated with improved pathogen clearance, disease control, and…”
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Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation by Talalay, Paul, Fahey, Jed W, Healy, Zachary R, Wehage, Scott L, Benedict, Andrea L, Min, Christine, Dinkova-Kostova, Albena T

“…UV radiation (UVR) is a complete carcinogen that elicits a constellation of pathological events, including direct DNA damage, generation of reactive oxidants…”
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Transcription factors NRF2 and HSF1 have opposing functions in autophagy by Dayalan Naidu, Sharadha, Dikovskaya, Dina, Gaurilcikaite, Egle, Knatko, Elena V., Healy, Zachary R., Mohan, Hema, Koh, Glenn, Laurell, Axel, Ball, Graeme, Olagnier, David, de la Vega, Laureano, Ganley, Ian G., Talalay, Paul, Dinkova-Kostova, Albena T.

“…Autophagy plays a critical role in the maintenance of cellular homeostasis by degrading proteins, lipids and organelles. Autophagy is activated in response to…”
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Stimulation of phagocytosis by sulforaphane by Suganuma, Hiroyuki, Fahey, Jed W., Bryan, Kelley E., Healy, Zachary R., Talalay, Paul

“…► Sulforaphane stimulates the phagocytosis of RAW 264.7 macrophages under conditions of serum deprivation. ► This effect does not require Nrf2-dependent…”
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Divergent Responses of Chondrocytes and Endothelial Cells to Shear Stress: Cross-Talk among COX-2, the Phase 2 Response, and Apoptosis by Healy, Zachary R., Lee, Norman H., Gao, Xiangqun, Goldring, Mary B., Talalay, Paul, Kensler, Thomas W., Konstantopoulos, Konstantinos

“…Fluid shear exerts anti-inflammatory and anti-apoptotic effects on endothelial cells by inducing the coordinated expression of phase 2 detoxifying and…”
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Heparin-based blood purification attenuates organ injury in baboons with Streptococcus pneumoniae pneumonia by Chen, Lingye, Kraft, Bryan D, Roggli, Victor L, Healy, Zachary R, Woods, Christopher W, Tsalik, Ephraim L, Ginsburg, Geoffrey S, Murdoch, David M, Suliman, Hagir B, Piantadosi, Claude A, Welty-Wolf, Karen E

“…Bacterial pneumonia is a major cause of morbidity and mortality worldwide despite the use of antibiotics, and novel therapies are urgently needed. Building on…”
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Shear-induced Cyclooxygenase-2 via a JNK2/c-Jun-dependent Pathway Regulates Prostaglandin Receptor Expression in Chondrocytic Cells by Abulencia, James P., Gaspard, Renee, Healy, Zachary R., Gaarde, William A., Quackenbush, John, Konstantopoulos, Konstantinos

“…Using cDNA microarrays coupled with bioinformatics tools, we elucidated a signaling cascade regulating cyclooxygenase-2 (COX-2), a pivotal pro-inflammatory…”
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Selectin Ligand Expression Regulates the Initial Vascular Interactions of Colon Carcinoma Cells: THE ROLES OF CD44V AND ALTERNATIVE SIALOFUCOSYLATED SELECTIN LIGANDS by Napier, Susan L, Healy, Zachary R, Schnaar, Ronald L, Konstantopoulos, Konstantinos

“…Selectin-mediated binding of tumor cells to platelets, leukocytes, and vascular endothelium may regulate their hematogenous spread in the microvasculature. We…”
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OMIP‐036: Co‐inhibitory receptor (immune checkpoint) expression analysis in human T cell subsets by Healy, Zachary R., Murdoch, David M.

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Inactivation of Tautomerase Activity of Macrophage Migration Inhibitory Factor by Sulforaphane: a Potential Biomarker for Anti-inflammatory Intervention by HEALY, Zachary R, HUA LIU, DAVID HOLTZCLAW, W, TALALAY, Paul

“…Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine with keto-enol tautomerase activity, rises rapidly in response to inflammation and is…”
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Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors by Healy, Zachary R., Dinkova‐Kostova, Albena T., Wehage, Scott L., Thompson, Richard E., Fahey, Jed W., Talalay, Paul

“…Background: We describe highly reproducible methods for quantifying the erythema response of precisely selected areas (spots) of human skin to graded doses of…”
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Selectin Ligand Expression Regulates the Initial Vascular Interactions of Colon Carcinoma Cells by Napier, Susan L., Healy, Zachary R., Schnaar, Ronald L., Konstantopoulos, Konstantinos

“…Selectin-mediated binding of tumor cells to platelets, leukocytes, and vascular endothelium may regulate their hematogenous spread in the microvasculature. We…”
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OMIP-XXX: Co-inhibitory Receptor (Immune Checkpoint) Expression Analysis in Human T cell subsets by Healy, Zachary R, Murdoch, David M

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Role of Paraoxonase 2 in Airway Epithelial Response to Oxidant Stress by McCravy, Matthew S., Yang, Zhonghui, Cyphert-Daly, Jaime, Healy, Zachary R., Vose, Aaron V., Kim, Haein R., Walker, Julia K. L., Tighe, Robert M., Gasier, Heath G., Ingram, Jennifer L., Que, Loretta G.

“…Asthma is a widespread chronic lung disease characterized by airway inflammation and hyperresponsiveness. This airway inflammation is classified by either the…”
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Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPbeta-dependent pathway by Healy, Zachary R, Zhu, Fei, Stull, Joshua D, Konstantopoulos, Konstantinos

“…Shear stress is a pathophysiologically relevant mechanical signal in cartilage biology and tissue engineering. Cyclooxygenase-2 (COX-2) is a pivotal…”
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Divergent responses of chondrocytes and endothelial cells to shear stress: Cross-talk among CO2, the phase 2 response, and apoptosis by Healy, Zachary R, Lee, Norman H, Gao, Xiangqun, Goldring, Mary B

“…Fluid shear exerts anti-inflammatory and anti-apoptotic effects on endothelial cells by inducing the coordinated expression of phase 2 detoxifying and…”
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