Search Results - "HEALY, E"

Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells by Hoang, Plansky, Wang, Jason, Conklin, Bruce R, Healy, Kevin E, Ma, Zhen

“…This protocol describes the generation of early-developing cardiac organoids from human pluripotent stem cells. Geometric confinement of the hiPSCs drives…”
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Directing cell migration and organization via nanocrater-patterned cell-repellent interfaces by Jeon, Hojeong, Koo, Sangmo, Reese, Willie Mae, Loskill, Peter, Grigoropoulos, Costas P., Healy, Kevin E.

“…Surfaces patterned lithographically with nanoscale craters can alter the morphology, migration and localization of cells, and can be designed to create…”
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Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications by Mathur, Anurag, Loskill, Peter, Shao, Kaifeng, Huebsch, Nathaniel, Hong, SoonGweon, Marcus, Sivan G., Marks, Natalie, Mandegar, Mohammad, Conklin, Bruce R., Lee, Luke P., Healy, Kevin E.

“…Drug discovery and development are hampered by high failure rates attributed to the reliance on non-human animal models employed during safety and efficacy…”
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μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips by Loskill, Peter, Marcus, Sivan G, Mathur, Anurag, Reese, Willie Mae, Healy, Kevin E

“…Human organ-on-a-chip systems for drug screening have evolved as feasible alternatives to animal models, which are unreliable, expensive, and at times…”
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WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue by Loskill, Peter, Sezhian, Thiagarajan, Tharp, Kevin M, Lee-Montiel, Felipe T, Jeeawoody, Shaheen, Reese, Willie Mae, Zushin, Peter-James H, Stahl, Andreas, Healy, Kevin E

“…Organ-on-a-chip systems possess a promising future as drug screening assays and as testbeds for disease modeling in the context of both single-organ systems…”
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A combined hiPSC-derived endothelial cell and in vitro microfluidic platform for assessing biomaterial-based angiogenesis by Natividad-Diaz, Sylvia L., Browne, Shane, Jha, Amit K., Ma, Zhen, Hossainy, Samir, Kurokawa, Yosuke K., George, Steven C., Healy, Kevin E.

“…Human induced pluripotent stem cell (hiPSC) derived angiogenesis models present a unique opportunity for patient-specific platforms to study the complex…”
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Identification of proteins associated with development of metastasis from cutaneous squamous cell carcinomas (cSCCs) via proteomic analysis of primary cSCCs by Shapanis, A., Lai, C., Smith, S., Coltart, G., Sommerlad, M., Schofield, J., Parkinson, E., Skipp, P., Healy, E.

“…Summary Background Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers capable of metastasizing. Proteomic analysis of cSCCs can provide…”
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Physiologically relevant organs on chips by Yum, Kyungsuk, Hong, Soon Gweon, Healy, Kevin E., Lee, Luke P.

“…Recent advances in integrating microengineering and tissue engineering have generated promising microengineered physiological models for experimental medicine…”
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Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues by Tharp, Kevin M., Kang, Michael S., Timblin, Greg A., Dempersmier, Jon, Dempsey, Garret E., Zushin, Peter-James H., Benavides, Jaime, Choi, Catherine, Li, Catherine X., Jha, Amit K., Kajimura, Shingo, Healy, Kevin E., Sul, Hei Sook, Saijo, Kaoru, Kumar, Sanjay, Stahl, Andreas

“…The activation of brown/beige adipose tissue (BAT) metabolism and the induction of uncoupling protein 1 (UCP1) expression are essential for BAT-based…”
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Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells by Allison, Thomas F., Andrews, Peter W., Avior, Yishai, Barbaric, Ivana, Benvenisty, Nissim, Bock, Christoph, Brehm, Jennifer, Brüstle, Oliver, Damjanov, Ivan, Elefanty, Andrew, Felkner, Daniel, Gokhale, Paul J., Halbritter, Florian, Healy, Lyn E., Hu, Tim X., Knowles, Barbara B., Loring, Jeanne F., Ludwig, Tenneille E., Mayberry, Robyn, Micallef, Suzanne, Mohamed, Jameelah S., Müller, Franz-Josef, Mummery, Christine L., Nakatsuji, Norio, Ng, Elizabeth S., Oh, Steve K. W., O’Shea, Orla, Pera, Martin F., Reubinoff, Benjamin, Robson, Paul, Rossant, Janet, Schuldt, Bernhard M., Solter, Davor, Sourris, Koula, Stacey, Glyn, Stanley, Edouard G., Suemori, Hirofumi, Takahashi, Kazutoshi, Yamanaka, Shinya

“…The International Stem Cell Initiative compared several commonly used approaches to assess human pluripotent stem cells (PSC). PluriTest predicts pluripotency…”
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Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales by Huebsch, Nathaniel, Loskill, Peter, Mandegar, Mohammad A, Marks, Natalie C, Sheehan, Alice S, Ma, Zhen, Mathur, Anurag, Nguyen, Trieu N, Yoo, Jennie C, Judge, Luke M, Spencer, C Ian, Chukka, Anand C, Russell, Caitlin R, So, Po-Lin, Conklin, Bruce R, Healy, Kevin E

“…Contractile motion is the simplest metric of cardiomyocyte health in vitro, but unbiased quantification is challenging. We describe a rapid automated method,…”
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Biomolecules from Macroalgae-Nutritional Profile and Bioactives for Novel Food Product Development by Healy, Laura E, Zhu, Xianglu, Pojić, Milica, Sullivan, Carl, Tiwari, Uma, Curtin, James, Tiwari, Brijesh K

“…Seaweed is in the spotlight as a promising source of nutrition for humans as the search for sustainable food production systems continues. Seaweed has a…”
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The regulation of food intake in mammalian hibernators: a review by Florant, Gregory L., Healy, Jessica E.

“…One of the most profound hallmarks of mammalian hibernation is the dramatic reduction in food intake during the winter months. Several species of hibernator…”
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Thiel Embalming Method for Cadaver Preservation: A Review of New Training Model for Urologic Skills Training by Healy, Samuel E, Rai, Bhavan Prasad, Biyani, Chandra Shekhar, Eisma, Roos, Soames, Roger W, Nabi, Ghulam

“…The use of endourology training models is on the rise. Surgical practice is moving toward a more minimally invasive approach and deficits in surgical exposure…”
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Matrix-Assisted Transplantation of Functional Beige Adipose Tissue by Tharp, Kevin M, Jha, Amit K, Kraiczy, Judith, Yesian, Alexandra, Karateev, Grigory, Sinisi, Riccardo, Dubikovskaya, Elena A, Healy, Kevin E, Stahl, Andreas

“…Novel, clinically relevant, approaches to shift energy balance are urgently needed to combat metabolic disorders such as obesity and diabetes. One promising…”
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HEV ORF2 protein-antibody complex deposits are associated with glomerulonephritis in hepatitis E with reduced immune status by Leblond, Anne-Laure, Helmchen, Birgit, Ankavay, Maliki, Lenggenhager, Daniela, Jetzer, Jasna, Helmchen, Fritjof, Yurtsever, Hueseyin, Parrotta, Rossella, Healy, Marc E., Pöschel, Amiskwia, Markkanen, Enni, Semmo, Nasser, Ferrié, Martin, Cocquerel, Laurence, Seeger, Harald, Hopfer, Helmut, Müllhaupt, Beat, Gouttenoire, Jérôme, Moradpour, Darius, Gaspert, Ariana, Weber, Achim

“…Hepatitis E virus (HEV) infection, one of the most common forms of hepatitis worldwide, is often associated with extrahepatic, particularly renal,…”
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Particulate and non-particulate steroids in spinal epidurals: a systematic review and meta-analysis by Feeley, I. H., Healy, E. F., Noel, J., Kiely, P. J., Murphy, T. M.

“…Background Steroids in transforaminal epidural injections are widely used to ease radicular pain in both cervical and lumbar radiculopathy. Concerns have been…”
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A Bioengineering Approach to Myopia Control Tested in a Guinea Pig Model by Garcia, Mariana B, Jha, Amit K, Healy, Kevin E, Wildsoet, Christine F

“…To investigate the biocompatibility of an injectable hydrogel and its ability to control myopia progression in guinea pigs. The study used a hydrogel…”
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TGF-β1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels by Browne, Shane, Jha, Amit K, Ameri, Kurosh, Marcus, Sivan G, Yeghiazarians, Yerem, Healy, Kevin E

“…Cell-based strategies for the treatment of ischemic diseases are at the forefront of tissue engineering and regenerative medicine. Cell therapies purportedly…”
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The effect of micronscale anisotropic cross patterns on fibroblast migration by Jeon, Hojeong, Hidai, Hirofumi, Hwang, David J, Healy, Kevin E, Grigoropoulos, Costas P

“…Abstract Cell movement on adhesive surfaces is a complicated process based on myriad cell–surface interactions. Although both micron and nanoscale surface…”
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