Search Results - "HAZELTON, William D"

Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma by Luebeck, Georg E, Vaughan, Thomas L, Curtius, Kit, Hazelton, William D

“…Patterns of cancer incidence, viewed over extended time periods, reveal important aspects of multistage carcinogenesis. Here we show how a multistage clonal…”
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Impact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975―2000 by MOOLGAVKAR, Suresh H, HOLFORD, Theodore R, MCCARTHY, William, BOER, Robert, GORLOVA, Olga, SCOTT GAZELLE, G, KIMMEL, Marek, MCMAHON, Pamela M, DE KONING, Harry J, FEUER, Eric J, LEVY, David T, CHUNG YIN KONG, FOY, Millenia, CLARKE, Lauren, JEON, Jihyoun, HAZELTON, William D, MEZA, Rafael, SCHULTZ, Frank

“…Considerable effort has been expended on tobacco control strategies in the United States since the mid-1950s. However, we have little quantitative information…”
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Cost-Effectiveness of Screening Patients with Gastroesophageal Reflux Disease for Barrett’s Esophagus With a Minimally Invasive Cell Sampling Device by Heberle, Curtis R., BS, Omidvari, Amir-Houshang, MD MPH, Ali, Ayman, BS, Kroep, Sonja, PhD, Kong, Chung Yin, PhD, Inadomi, John M., MD, Rubenstein, Joel H., MD MS, Tramontano, Angela C., MPH, Dowling, Emily C., MHS, Hazelton, William D., PhD, Luebeck, E. Georg, PhD, Lansdorp-Vogelaar, Iris, PhD, Hur, Chin, MD MPH

“…Abstract Background & Aims It is important to identify patients with Barrett’s esophagus (BE), the precursor to esophageal adenocarcinoma (EAC). Patients with…”
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A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus by Curtius, Kit, Wong, Chao-Jen, Hazelton, William D, Kaz, Andrew M, Chak, Amitabh, Willis, Joseph E, Grady, William M, Luebeck, E Georg

“…Biomarkers that drift differentially with age between normal and premalignant tissues, such as Barrett's esophagus (BE), have the potential to improve the…”
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A Multiscale Model Evaluates Screening for Neoplasia in Barrett's Esophagus by Curtius, Kit, Hazelton, William D, Jeon, Jihyoun, Luebeck, E Georg

“…Barrett's esophagus (BE) patients are routinely screened for high grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) through endoscopic screening,…”
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Chapter 8: The FHCRC Lung Cancer Model by Hazelton, William D., Jeon, Jihyoun, Meza, Rafael, Moolgavkar, Suresh H.

“…As a member of the Cancer Intervention and Surveillance Modeling Network (CISNET), the lung cancer (LC) group at Fred Hutchinson Cancer Research Center (FHCRC)…”
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Epigenetic Aging: More Than Just a Clock When It Comes to Cancer by Yu, Ming, Hazelton, William D, Luebeck, Georg E, Grady, William M

“…The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced chronologic age is one of the most significant risk factors for…”
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Multistage Carcinogenesis and Lung Cancer Mortality in Three Cohorts by HAZELTON, William D, CLEMENTS, Mark S, MOOLGAVKAR, Suresh H

“…Experimental evidence indicates that tobacco smoke acts both as an initiator and a promoter in lung carcinogenesis. We used the two-stage clonal expansion…”
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Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma by Luebeck, E Georg, Curtius, Kit, Hazelton, William D, Maden, Sean, Yu, Ming, Thota, Prashanthi N, Patil, Deepa T, Chak, Amitabh, Willis, Joseph E, Grady, William M

“…Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift…”
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Benefits and Harms of Computed Tomography Lung Cancer Screening Strategies: A Comparative Modeling Study for the U.S. Preventive Services Task Force by DE KONING, Harry J, MEZA, Rafael, SUNG EUN CHOI, PINSKY, Paul F, DE GONZALEZ, Amy Berrington, BERG, Christine D, BLACK, William C, TAMMEMÄGI, Martin C, HAZELTON, William D, FEUER, Eric J, MCMAHON, Pamela M, PLEVRITIS, Sylvia K, TEN HAAF, Kevin, MUNSHI, Vidit N, JIHYOUN JEON, ERDOGAN, Saadet Ayca, CHUNG YIN KONG, HAN, Summer S, VAN ROSMALEN, Joost

“…The optimum screening policy for lung cancer is unknown. To identify efficient computed tomography (CT) screening scenarios in which relatively more lung…”
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Impact of Tumor Progression on Cancer Incidence Curves by GEORG LUEBECK, E, CURTIUS, Kit, JEON, Jihyoun, HAZELTON, William D

“…Cancer arises through a multistage process, but it is not fully clear how this process influences the age-specific incidence curve. Studies of colorectal and…”
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Multimodal T Cell Analysis with CoNGA by Schattgen, Stefan A, Hazelton, William D, Thomas, Paul G, Bradley, Philip

“…Advances in single-cell technologies have made it possible to simultaneously quantify gene expression and immune receptor sequence across thousands of…”
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Optimal Timing for Cancer Screening and Adaptive Surveillance Using Mathematical Modeling by Curtius, Kit, Dewanji, Anup, Hazelton, William D, Rubenstein, Joel H, Luebeck, Georg E

“…Cancer screening and early detection efforts have been partially successful in reducing incidence and mortality, but many improvements are needed. Although…”
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Endoscopic Screening Program for Control of Esophageal Adenocarcinoma in Varied Populations: A Comparative Cost-Effectiveness Analysis by Rubenstein, Joel H., Omidvari, Amir-Houshang, Lauren, Brianna N., Hazelton, William D., Lim, Francesca, Tan, Sarah Xinhui, Kong, Chung Yin, Lee, Minyi, Ali, Ayman, Hur, Chin, Inadomi, John M., Luebeck, Georg, Lansdorp-Vogelaar, Iris

“…Guidelines suggest endoscopic screening for esophageal adenocarcinoma (EAC) among individuals with symptoms of gastroesophageal reflux disease (GERD) and…”
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Weight-loss therapy in patients with obesity with endometrial intraepithelial neoplasia and uterine cancer by Suzuki, Yukio, Chen, Ling, Matsuo, Koji, Ferris, Jennifer S., Elkin, Elena B., Melamed, Alexander, Kong, Chung Yin, Bickell, Nina, Myers, Evan R., Havrilesky, Laura J., Xu, Xiao, Blank, Stephanie V., Hazelton, William D., Hershman, Dawn L., Wright, Jason D.

“…Although obesity is an important risk factor for endometrial intraepithelial neoplasia (EIN) and uterine cancer, little is known about the trends in use of…”
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The Optimal Age to Stop Endoscopic Surveillance of Patients With Barrett’s Esophagus Based on Sex and Comorbidity: A Comparative Cost-Effectiveness Analysis by Omidvari, Amir-Houshang, Hazelton, William D., Lauren, Brianna N., Naber, Steffie K., Lee, Minyi, Ali, Ayman, Seguin, Claudia, Kong, Chun Yin, Richmond, Ellen, Rubenstein, Joel H., Luebeck, Georg E., Inadomi, John M., Hur, Chin, Lansdorp-Vogelaar, Iris

“…Current guidelines recommend surveillance for patients with nondysplastic Barrett’s esophagus (NDBE) but do not include a recommended age for discontinuing…”
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Trends in uterine cancer incidence in the United States: The contribution of age, period and cohort effects by Ferris, Jennifer S., Prest, Matthew T., Hur, Chin, Chen, Ling, Elkin, Elena B., Melamed, Alex, Kong, Chung Yin, Myers, Evan R., Havrilesky, Laura J., Blank, Stephanie V., Hazelton, William D., Wright, Jason D.

“…In the U.S., uterine cancer incidence is rising, with racial and ethnic minorities experiencing the largest increases. We performed age-period-cohort analyses…”
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Optimizing Management of Patients With Barrett’s Esophagus and Low-Grade or No Dysplasia Based on Comparative Modeling by Omidvari, Amir-Houshang, Ali, Ayman, Hazelton, William D., Kroep, Sonja, Lee, Minyi, Naber, Steffie K., Lauren, Brianna N., Ostvar, Sassan, Richmond, Ellen, Kong, Chun Yin, Rubenstein, Joel H., Lansdorp-Vogelaar, Iris, Luebeck, Georg, Hur, Chin, Inadomi, John

“…Endoscopic treatment is recommended for patients with Barrett’s esophagus (BE) with high-grade dysplasia, yet clinical management recommendations are…”
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The impact of overdiagnosis on the selection of efficient lung cancer screening strategies by Han, Summer S., ten Haaf, Kevin, Hazelton, William D., Munshi, Vidit N., Jeon, Jihyoun, Erdogan, Saadet A., Johanson, Colden, McMahon, Pamela M., Meza, Rafael, Kong, Chung Yin, Feuer, Eric J., de Koning, Harry J., Plevritis, Sylvia K.

“…The U.S. Preventive Services Task Force (USPSTF) recently updated their national lung screening guidelines and recommended low‐dose computed tomography (LDCT)…”
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Implications of Epigenetic Drift in Colorectal Neoplasia by Luebeck, Georg E, Hazelton, William D, Curtius, Kit, Maden, Sean K, Yu, Ming, Carter, Kelly T, Burke, Wynn, Lampe, Paul D, Li, Christopher I, Ulrich, Cornelia M, Newcomb, Polly A, Westerhoff, Maria, Kaz, Andrew M, Luo, Yanxin, Inadomi, John M, Grady, William M

“…Many normal tissues undergo age-related drift in DNA methylation, providing a quantitative measure of tissue age. Here, we identify and validate 781 CpG…”
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