Search Results - "HAYMAN, A. R"

Physicochemical characterization and dissolution properties of meloxicam–cyclodextrin binary systems by Naidu, N.Buchi, Chowdary, K.P.R., Murthy, K.V.R., Satyanarayana, V., Hayman, A.R., Becket, G.

“…The objective of the work is physicochemical characterization of meloxicam (ME)–cyclodextrin (CD) binary systems both in solution and solid states and to…”
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Mice lacking tartrate‐resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus by Bune, A. J., Hayman, A. R., Evans, M. J., Cox, T. M.

“…Summary Tartrate‐resistant acid phosphatase (TRAP) is a lysosomal di‐iron protein of mononuclear phagocytes and osteoclasts. Hitherto, no role for the enzyme…”
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Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice by Suter, A, Everts, V, Boyde, A, Jones, S J, Lüllmann-Rauch, R, Hartmann, D, Hayman, A R, Cox, T M, Evans, M J, Meister, T, von Figura, K, Saftig, P

“…To date, two lysosomal acid phosphatases are known to be expressed in cells of the monocyte/phagocyte lineage: the ubiquitously expressed lysosomal acid…”
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Purple acid phosphatase of the human macrophage and osteoclast. Characterization, molecular properties, and crystallization of the recombinant di-iron-oxo protein secreted by baculovirus-infected insect cells by HAYMAN, A. R, COX, T. M

“…The purple phosphatases catalyze hydrolysis of phosphate esters (optimum pH approximately 5) and are resistant to inhibition by dextro-rotatory tartrate; their…”
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Tartrate-resistant Acid Phosphatase (Acp 5): Identification in Diverse Human Tissues and Dendritic Cells by Hayman, Alison R, Macary, Paul, Lehner, Paul J, Cox, Timothy M

“…Histochemical demonstration of tartrate-resistant acid phosphatase (TRAP) is used for the specific identification of osteoclasts. The enzyme, which we have…”
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Purification and characterization of a tartrate-resistant acid phosphatase from human osteoclastomas by Hayman, A R, Warburton, M J, Pringle, J A, Coles, B, Chambers, T J

“…Tartrate-resistant acid phosphatase is one of the major enzymes produced and secreted by osteoclasts. To obtain sufficient enzyme for biochemical…”
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Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity by Perez-Amodio, S, Jansen, D C, Schoenmaker, T, Vogels, I M C, Reinheckel, T, Hayman, A R, Cox, T M, Saftig, P, Beertsen, W, Everts, V

“…Bone resorption by osteoclasts depends on the activity of various proteolytic enzymes, in particular those belonging to the group of cysteine proteinases. Next…”
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Generation and characterization of monoclonal antibodies to human type-5 tartrate-resistant acid phosphatase: development of a specific immunoassay of the isoenzyme in serum by Chamberlain, P, Compston, J, Cox, T M, Hayman, A R, Imrie, R C, Reynolds, K, Holmes, S D

“…We have characterized four monoclonal antibodies (mAbs) to the purple ("tartrate-resistant," band 5) acid phosphatase of the human osteoclast (TRAP) and used…”
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Physicochemical characterization and dissolution properties of nimesulide-cyclodextrin binary systems by Nalluri, Buchi N, Chowdary, K P R, Murthy, K V R, Hayman, A R, Becket, G

“…The objective of this work is physicochemical characterization of nimesulide-cyclodextrin binary systems both in solution and solid state and to improve the…”
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Tartrate‐Resistant Acid Phosphatase Knockout Mice by Hayman, Alison R, Cox, Timothy M

“…TRACP is a lysosomal enzyme found in diverse tissues, where it is expressed in dendritic cells as well as osteoclasts and macrophages. To investigate the…”
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Pathologic gene expression in Gaucher disease: up-regulation of cysteine proteinases including osteoclastic cathepsin K by Moran, Mary Teresa, Schofield, J. Paul, Hayman, Alison R., Shi, Guo-Ping, Young, Elisabeth, Cox, Timothy M.

“…Deficiency of lysosomal acid β-glucosidase induces glycolipid storage in the macrophages of Gaucher disease but the pathways of multisystem tissue injury and…”
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Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis by Hayman, A R, Jones, S J, Boyde, A, Foster, D, Colledge, W H, Carlton, M B, Evans, M J, Cox, T M

“…Mature osteoclasts specifically express the purple, band 5 isozyme (Acp 5) of tartrate-resistant acid phosphatase, a binuclear metalloenzyme that can generate…”
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Super-Microporous Silicate Molecular Sieves by Bagshaw, S. A., Hayman, A. R.

“…A new synthesis of supermicroporous silica (1.6–2.0 nm diameter), using micelles of a quaternary ω‐hydroxyalkylammonium salt, is presented by the authors. The…”
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Calvarial Osteoclasts Express a Higher Level of Tartrate-Resistant Acid Phosphatase Than Long Bone Osteoclasts and Activation Does not Depend on Cathepsin K or L Activity by Perez-Amodio, S., Jansen, D. C., Schoenmaker, T., Vogels, I. M. C., Reinheckel, T., Hayman, A. R., Cox, T. M., Saftig, P., Beertsen, W., Everts, V.

“…The online version of the original article can be found under doi: 10.1007/s00223-005-0289-z…”
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Osteoclastic Tartrate-resistant Acid Phosphatase (Acp 5): Its Localization to Dendritic Cells and Diverse Murine Tissues by Hayman, Alison R, Bune, Alison J, Bradley, John R, Rashbass, Jeremy, Cox, Timothy M

“…Tartrate-resistant acid phosphatase (TRAP) is a histochemical marker of the osteoclast. It is also characteristic of monohistiocytes, particularly alveolar…”
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Tartrate-resistant acid phosphatase from human osteoclastomas is translated as a single polypeptide by Hayman, A R, Dryden, A J, Chambers, T J, Warburton, M J

“…Tartrate-resistant acid phosphatases have been isolated from a number of sources. These enzymes consist of one subunit (Mr 30,000-40,000) or two dissimilar…”
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Human osteoclastomas contain multiple forms of cathepsin B by Page, A E, Warburton, M J, Chambers, T J, Pringle, J A, Hayman, A R

“…During bone resorption, the osteoclast secretes hydrolytic enzymes into the sealing zone which it creates between itself and the bone surface. Since this…”
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Krafft Temperature Depression in Quaternary Ammonium Bromide Surfactants by Davey, Tim W, Ducker, William A, Hayman, Alan R, Simpson, Jim

“…Substitution of a triethyl for a trimethyl headgroup in alkyltrimethylammonium or (ω-hydroxyalkyl)trimethylammonium bromide surfactants leads to a significant…”
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The triple-helical domain of alpha 2(VI) collagen is encoded by 19 short exons that are multiples of 9 base pairs by A R Hayman, J Köppel, K H Winterhalter, B Trueb

“…We have analyzed the structure of the gene coding for the alpha 2(VI) subunit of chicken type VI collagen. The triple-helical domain of this polypeptide is…”
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Purification and characterisation of cysteine proteinases from human osteoclastomas by Page, A, Warburton, M J, Chambers, T J, Hayman, A R

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