Search Results - "HAWKINS, N J"

Constraints on the evolution of azole resistance in plant pathogenic fungi by Cools, H. J., Hawkins, N. J., Fraaije, B. A.

“…The durability of azole fungicides in controlling agriculturally important pathogenic fungi is unique amongst modern single site fungicides. Today, azoles are…”
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Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma by Carr, N J, Mahajan, H, Tan, K L, Hawkins, N J, Ward, R L

“…To determine the prevalence of colorectal polyps of different types in an unselected population, and to correlate the morphological diagnoses with BRAF…”
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RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas by Deb, S, Xu, H, Tuynman, J, George, J, Yan, Y, Li, J, Ward, R L, Mortensen, N, Hawkins, N J, McKay, M J, Ramsay, R G, Fox, S B

“…Background: RAD21 is a component of the cohesion complex and is integral to chromosome segregation and error-free DNA repair. RAD21 is functionally important…”
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Colorectal cancer: a model for epigenetic tumorigenesis by Wong, J J L, Hawkins, N J, Ward, R L

“…Table 1 Milestones in cancer genetics and epigenetics, in relation to the clinical management of colorectal cancer Decade Genetics 3 Epigenetics 4 Clinical…”
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Fitness Penalties in the Evolution of Fungicide Resistance by Hawkins, N.J, Fraaije, B.A

“…The evolution of resistance poses an ongoing threat to crop protection. Fungicide resistance provides a selective advantage under fungicide selection, but…”
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Sporadic Colorectal Cancers With Microsatellite Instability and Their Possible Origin in Hyperplastic Polyps and Serrated Adenomas by Hawkins, Nicholas John, Ward, Robyn Lynne

“…Background: Microsatellite instability (MSI) is seen in 10%–15% of sporadic colorectal cancers mostly in the right colon, but the precursors of cancers with…”
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The role of MYH and microsatellite instability in the development of sporadic colorectal cancer by COLEBATCH, A, HITCHINS, M, WILLIAMS, R, MEAGHER, A, HAWKINS, N. J, WARD, R. L

“…Biallelic germline mutations in MYH are associated with colorectal neoplasms, which develop through a pathway involving somatic inactivation of APC. In this…”
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Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer by HAWKINS, N. J, TOMLINSON, I, MEAGHER, A, WARD, R. L

“…Chromosomal instability and microsatellite instability represent the major pathways for colorectal cancer (CRC) progression. However, a significant percentage…”
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Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis by Christie, M, Jorissen, R N, Mouradov, D, Sakthianandeswaren, A, Li, S, Day, F, Tsui, C, Lipton, L, Desai, J, Jones, I T, McLaughlin, S, Ward, R L, Hawkins, N J, Ruszkiewicz, A R, Moore, J, Burgess, A W, Busam, D, Zhao, Q, Strausberg, R L, Simpson, A J, Tomlinson, I P M, Gibbs, P, Sieber, O M

“…Biallelic protein-truncating mutations in the adenomatous polyposis coli ( APC ) gene are prevalent in sporadic colorectal cancer (CRC). Mutations may not be…”
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Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling by Henry, C., Quadir, A., Hawkins, N. J., Jary, E., Llamosas, E., Kumar, D., Daniels, B., Ward, R. L., Ford, C. E.

“…Purpose Wnt signalling has been implicated in breast cancer, and in particular aberrant β-catenin-independent Wnt signalling has been associated with breast…”
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Developmentally-regulated expression of murine K-ras isoforms by PELLS, S, DIVJAK, M, ROMANOWSKI, P, IMPEY, H, HAWKINS, N. J, CLARKE, A. R, HOOPER, M. L, WILLIAMSON, D. J

“…The products (p21) of the three mammalian H-, N- and K-ras genes play important roles in intracellular signal transduction, linking membrane receptor kinases…”
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Loop‐mediated isothermal amplification (LAMP) assays for rapid detection of Pyrenopeziza brassicae (light leaf spot of brassicas) by King, K. M., Krivova, V., Canning, G. G. M., Hawkins, N. J., Kaczmarek, A. M., Perryman, S. A. M., Dyer, P. S., Fraaije, B. A., West, J. S.

“…Pyrenopeziza brassicae (anamorph Cylindrosporium concentricum) is an ascomycete fungus that causes light leaf spot (LLS) disease of brassicas. It has recently…”
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Colorectal Carcinomas Arising in the Hyperplastic Polyposis Syndrome Progress through the Chromosomal Instability Pathway by Hawkins, Nicholas J., Gorman, Patricia, Tomlinson, Ian P.M., Bullpitt, Peter, Ward, Robyn L.

“…The hyperplastic polyposis syndrome is characterized by the presence within the colon of multiple large hyperplastic polyps. We describe a case of hyperplastic…”
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Activation of the K‐ras oncogene in colorectal neoplasms is Associated with decreased apoptosis by Ward, Robyn L., Todd, Alison V., Santiago, Fernando, O'Connor, Terence, Hawkins, Nicholas J.

“…BACKGROUND Recent in vitro data indicate that the oncogenic effects of activated ras genes may be mediated, at least in part, through inhibition of apoptotic…”
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The collagenase-1 (MMP-1) gene promoter polymorphism - 1607 2G is associated with favourable prognosis in patients with colorectal cancer by Hettiaratchi, A, Hawkins, N J, McKenzie, G, Ward, R L, Hunt, J E, Wakefield, D, Di Girolamo, N

“…Matrix metalloproteinase (MMP) overexpression has been implicated in the pathogenesis of colorectal carcinoma (CRC). Accumulating evidence suggests that MMP…”
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Isolation of human anti‐c‐erbB‐2 Fabs from a lymph node‐derived phage display library by CLARK, M. A., HAWKINS, N. J., PAPAIOANNOU, A., FIDDES, R. J., WARD, R. L.

“…An immunoglobulin phage display library constructed from a tumour‐associated pericolic lymph node was panned against the extracellular domain of the…”
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The null oncogene hypothesis and protection from cancer by Davenport, M P, Ward, R L, Hawkins, N J

“…Tumour progression involves the inactivation of tumour suppressor genes and the activation of proto-oncogenes. Inactivation of both copies of a tumour…”
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Retrieval of human antibodies from phage-display libraries using enzymatic cleavage by Ward, R.L., Clark, M.A., Lees, J., Hawkins, N.J.

“…A combinatorial human IgG1,κ gene library of 2 × 10 7 clones was constructed from a pericolic lymph node using the phagemid vector pComb3H. Fabs with binding…”
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Large-Scale Delineation of Secreted Protein Biomarkers Overexpressed in Cancer Tissue and Serum by Welsh, John B., Sapinoso, Lisa M., Kern, Suzanne G., Brown, David A., Liu, Tao, Bauskin, Asne R., Ward, Robyn L., Hawkins, Nicholas J., Quinn, David I., Russell, Pamela J., Sutherland, Robert L., Breit, Samuel N., Moskaluk, Christopher A., Frierson, Henry F., Hampton, Garret M.

“…Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory autocrine and paracrine signals, involving overexpression of secreted…”
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Biodistribution of filamentous phage-Fab in nude mice by Yip, Yum L, Hawkins, Nicholas J, Smith, Glenn, Ward, Robyn L

“…In vivo panning of peptide libraries in mice has allowed the isolation of peptides which target the vasculature of specific organs. The application of this…”
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