Search Results - "HAWKINS, Lynda K"

An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathway-defective tumors: Dependence on E1A, the E2F-1 promoter, and viral replication for selectivity and efficacy by JAKUBCZAK, John L, RYAN, Patricia, PINKSTAFF, Anne, SHIRLEY, Pamela, SKRIPCHENKO, Yelena, STEWART, David, FORRY-SCHAUDIES, Suzanne, HALLENBECK, Paul L, GORZIGLIA, Mario, CLARKE, Lori, HAWKINS, Lynda K, HAY, Carl, YING HUANG, KALOSS, Michele, MARINOV, Anthony, PHIPPS, Sandrina

“…The use of oncolytic adenoviruses as a cancer therapeutic is dependent on the lytic properties of the viral life cycle, and the molecular differences between…”
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Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2 by SCHEPELMANN, Silke, HALLENBECK, Paul, SPRINGER, Caroline J, OGILVIE, Lesley M, HEDLEY, Douglas, FRIEDLOS, Frank, MARTIN, Janet, SCANLON, Ian, HAY, Carl, HAWKINS, Lynda K, MARAIS, Richard

“…Hepatocellular carcinoma is the fifth most common cancer worldwide, and there is no effective therapy for unresectable disease. We have developed a targeted…”
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Multigene expression from a replicating adenovirus using native viral promoters by Bauzon, Maxine, Castro, Daniel, Karr, Michael, Hawkins, Lynda K, Hermiston, Terry W

“…We have developed a novel therapeutic gene delivery system for oncolytic adenoviruses that takes advantage of the endogenous gene expression machinery…”
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Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer by Ryan, Patricia C, Jakubczak, John L, Stewart, David A, Hawkins, Lynda K, Cheng, Cheng, Clarke, Lori M, Ganesh, Shanthi, Hay, Carl, Huang, Ying, Kaloss, Michele, Marinov, Anthony, Phipps, Sandrina S, Reddy, P Seshidhar, Shirley, Pamela S, Skripchenko, Yelena, Xu, Ling, Yang, Jingping, Forry-Schaudies, Suzanne, Hallenbeck, Paul L

“…A potentially promising treatment of metastatic cancer is the systemic delivery of oncolytic adenoviruses. This requires engineering viruses which selectively…”
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Presence of an intron in elongator methionine-tRNA of Halobacterium volcanii by Datta, P K, Hawkins, L K, Gupta, R

“…The gene for the elongator (internal) methionine transfer RNA (tRNA(mMet)) in the archaebacterium Halobacterium volcanii contains a 75 base pair intron…”
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Oncolytic biotherapy: a novel therapeutic plafform by Hawkins, Lynda K, Lemoine, Nick R, Kirn, David

“…There is a clear need for new, selective, cancer treatments that do not cause the cross-resistance which occurs with currently available chemotherapeutic…”
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The E3-20.5K Membrane Protein of Subgroup B Human Adenoviruses Contains O-Linked and Complex N-Linked Oligosaccharides by Hawkins, Lynda K., Wold, William S.M.

“…Subgroup 6 adenoviruses (Ad3, -7, -11, -35) contain two open reading frames (ORFs) in the early E3 transcription unit that are not present in subgroup C…”
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A 20,500-Dalton Protein is Coded by Region E3 of Subgroup B but Not Subgroup C Human Adenoviruses by Hawkins, Lynda K., Wold, William S.M.

“…There is an open reading frame (ORF) between ATG2089 and TGA2856 in the early E3 transcription unit of subgroup B adenovirus 3 (Ad3) that could encode a…”
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A 12,500 MW protein is coded by region E3 of adenovirus by Hawkins, L K, Wold, W S

“…There is an open reading frame between ATG291 and TGA612 in the early region E3 transcription unit of adenovirus 2 (Ad2) that could encode a protein of 12,500…”
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Region E3 of subgroup B human adenoviruses encodes a 16-kilodalton membrane protein that may be a distant analog of the E3-6.7K protein of subgroup C adenoviruses by Hawkins, L K, Wilson-Rawls, J, Wold, W S

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