Search Results - "HAWCOCK, A. B"

GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity by Gardner, C J, Armour, D R, Beattie, D T, Gale, J D, Hawcock, A B, Kilpatrick, G J, Twissell, D J, Ward, P

“…It has been demonstrated recently that antagonists of the tachykinin NK1 receptor, specifically CP-99,994 and GR203040, possess anti-emetic activity in a range…”
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The pharmacology of GR203040, a novel, potent and selective non‐peptide tachykinin NK1 receptor antagonist by Beattie, D.T., Beresford, I.J.M., Connor, H.E., Marshall, F.H., Hawcock, A.B., Hagan, R.M., Bowers, J., Birch, P.J., Ward, P.

“…1 The in vitro and in vivo pharmacology of GR203040 ((2S, 3S)‐2‐methoxy‐5‐tetrazol‐1‐yl‐benzyl‐(2‐phenyl‐piperidin‐3‐yl)‐amine), a novel, highly potent and…”
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Pharmacological characterization of the contractile responses to angiotensin analogues in guinea‐pig isolated longitudinal muscle of small intestine by Hawcock, A.B., Barnes, J.C.

“…1 The contractile responses to angiotensin II, angiotensin III and two synthetic analogues, [Lys2] angiotensin II and [Sar1]angiotensin II, in the guinea‐pig…”
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1,4-Benzodiazepin-2-one derived neurokinin-1 receptor antagonists by Armour, D.R., Aston, N.M., Morriss, K.M.L., Congreve, M.S., Hawcock, A.B., Marquess, D., Mordaunt, J.E., Richards, S.A., Ward, P.

“…The identification of a series of 1,4-benzodiazepin-2-one derived NK 1 receptor antagonists is described and a bioactive conformation is proposed. A new class…”
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Pharmacological characterization of angiotensin‐induced depolarizations of rat superior cervical ganglion in vitro by Hawcock, A.B., Barnes, J.C., Michel, A.D.

“…1 The depolarizing responses to angiotensin II and angiotensin III of the rat superior cervical ganglion have been characterized in vitro, by the use of…”
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Temperature and agonist dependency of tachykinin NK1 receptor antagonist potencies in rat isolated superior cervical ganglion by HAWCOCK, A. B, BERESFORD, I. J. M, MARSHALL, F. H, HAGAN, R. M

“…Using rat isolated superior cervical ganglion we have further characterised tachykinin NK1 receptors and investigated the possible existence of tachykinin NK1…”
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The depolarising action of capsaicin on rat isolated sciatic nerve by Hayes, A G, Hawcock, A B, Hill, R G

“…The effect of capsaicin on the isolated sciatic nerve of rat was studied by extracellular recording of membrane polarisation. Capsaicin depolarised the sciatic…”
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GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors by BERESFORD, I. J. M, SHELDRICK, R. L. G, BALL, D. I, TURPIN, M. P, WALSH, D. M, HAWCOCK, A. B, COLEMAN, R. A, HAGAN, R. M, TYERS, M. B

“…GR159897 ((R)-1-[2-(5-fluoro-1H-indol-3-yl)ethyl]-4-methoxy-4- [(phenylsulfinyl)methyl]piperidine) is a novel, highly potent and selective non-peptide…”
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Effect of single point mutations of the human tachykinin NK1 receptor on antagonist affinity by Lundstrom, K, Hawcock, A B, Vargas, A, Ward, P, Thomas, P, Naylor, A

“…Molecular modelling and site-directed mutagenesis were used to identify eleven amino acid residues which may be involved in antagonist binding of the human…”
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Agonist effects of [D-Pro2,D-Phe7,D-Trp9]substance P--evidence for different receptors by Hawcock, A B, Hayes, A G, Tyers, M B

“…[D-Pro2,D-Phe7,D-Trp9]substance P contracted guinea-pig ileum (GPI) indirectly, probably via substance P (SP) receptors on postganglionic parasympathetic…”
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Effect of single point mutations of the human tachykinin NK1receptor on antagonist affinity by LUNDSTROM, K, HAWCOCK, A. B, VARGAS, A, WARD, P, THOMAS, P, NAYLOR, A

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GR205171 : A novel antagonist with high affinity for the trachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity by GARDNER, C. J, ARMOUR, D. R, BEATTIE, D. T, GALE, J. D, HAWCOCK, A. B, KILPATRICK, G. J, TWISSELL, D. J, WARD, P

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Temperature and agonist dependency of tachykinin NK sub(1) receptor antagonist potencies in rat isolated superior cervical ganglion by Hawcock, AB, Beresford, IJM, Marshall, F H, Hagan, R M

“…Using rat isolated superior cervical ganglion we have further characterised tachykinin NK sub(1) receptors and investigated the possible existence of…”
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The pharmacology of GR203040, a novel, potent and selective non-peptide tachykinin NK sub(1) receptor antagonist by Beattie, D T, Beresford, IJM, Connor, HE, Marshall, F H, Hawcock, AB, Hagan, R M, Bowers, J, Birch, P J, Ward, P

“…The in vitro and in vivo pharmacology of GR203040 ((2S, 3S)-2-methoxy-5-tetrazol-1-yl-benzyl-(2-phenyl-piperidin-3-yl)-ami ne), a novel, highly potent and…”
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