Search Results - "HAVERKAMP, L. J"

The value of database controls in pilot or futility studies in ALS by CZAPLINSKI, A, HAVERKAMP, L. J, YEN, A. A, SIMPSON, E. P, LAI, E. C, APPEL, S. H

“…To evaluate the use and reliability of database controls in place of a placebo group in pilot or "futility" ALS trials. We compared the rates of disease…”
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Prevalence and correlates of neuropsychological deficits in amyotrophic lateral sclerosis by Massman, P J, Sims, J, Cooke, N, Haverkamp, L J, Appel, V, Appel, S H

“…OBJECTIVE: To determine the prevalence and correlates of neuropsychological impairment in a large cohort (n = 146) of patients with typical, sporadic…”
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Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain by Giulian, Dana, Haverkamp, Lanny J., Li, Jun, Karshin, William L., Yu, Jenny, Tom, Donald, Li, Xia, Kirkpatrick, Joel B.

“…Senile plaques found in the brains of patients with Alzheimer's disease (AD) are surrounded by clusters of reactive microglia. Isolated human microglia placed…”
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Reduction of Naturally Occurring Motoneuron Death in Vivo by a Target-Derived Neurotrophic Factor by Oppenheim, Ronald W., Haverkamp, Lanny J., Prevette, David, McManaman, James L., Appel, Stanley H.

“…Treatment of chick embryos in ovo with crude and partially purified extracts from embryonic hindlimbs (days 8 to 9) during the normal cell death period (days 5…”
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Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction by Haverkamp, L J, Appel, V, Appel, S H

“…Over 1200 patients with motor neuron disease have been carefully diagnosed, followed, and included in a detailed database delineating characteristics of the…”
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Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease by Roher, Alex E., Chaney, Michael O., Kuo, Yu-Min, Webster, Scott D., Stine, W. Blaine, Haverkamp, Lanny J., Woods, Amina S., Cotter, Robert J., Tuohy, James M., Krafft, Grant A., Bonnell, Barry S., Emmerling, Mark R.

“…In the course of analyzing the chemical composition of Alzheimer's disease neuritic and vascular amyloid, we have purified stable dimeric and trimeric…”
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Anatomical and physiological development of the Xenopus embryonic motor system in the absence of neural activity by Haverkamp, LJ

“…Embryos of Xenopus laevis were continually immobilized by immersion in solutions of either chloretone or lidocaine, from the late neural-fold stage to the…”
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Behavioral development in the absence of neural activity: effects of chronic immobilization on amphibian embryos by Haverkamp, LJ, Oppenheim, RW

“…Embryos of Xenopus laevis and Ambystoma mexicanum were continually immobilized from premotile stages of development to stages at which normally reared embryos…”
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Specific Domains of beta -Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia by Giulian, Dana, Haverkamp, Lanny J, Yu, J. H, Karshin, William, Tom, D, Li, Jun, Kirkpatrick, Joel, Kuo, Y.-M, Roher, A. E

“…Alzheimer's disease (AD) is found to have striking brain inflammation characterized by clusters of reactive microglia that surround senile plaques. A recent…”
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The HHQK Domain of β-Amyloid Provides a Structural Basis for the Immunopathology of Alzheimer's Disease by Giulian, Dana, Haverkamp, Lanny J., Yu, Jiahan, Karshin, William, Tom, Donald, Li, Jun, Kazanskaia, Anna, Kirkpatrick, Joel, Roher, Alex E.

“…The β-amyloid peptide 1–42 (Aβ1–42), a major component of neuritic and core plaques found in Alzheimer's disease, activates microglia to kill neurons…”
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Nigral damage and dopaminergic hypofunction in mesencephalon-immunized guinea pigs by Appel, S H, Le, W D, Tajti, J, Haverkamp, L J, Engelhardt, J I

“…To support a potential role for immune mechanisms in the destruction of substantia nigra (SN) neurons, guinea pigs were immunized with bovine mesencephalon…”
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Skeletal muscle proteins rescue motor neurons from cell death in vivo by McManaman, J L, Haverkamp, L J, Oppenheim, R W

“…Because embryonic neurons are more sensitive to the effects of target derived factors than adult neurons, the developing nervous system provides a sensitive…”
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The regulation of motoneuron survival and differentiation by putative muscle-derived neurotrophic agents: neuromuscular activity and innervation by HOUENOU, L. J, HAVERKAMP, L. J, MCMANAMAN, J. L, OPPENHEIM, R. W

“…The chronic blockade of neuromuscular activity is known to promote the survival of developing motoneurons in vivo in the chick, mouse and rat embryo. Increased…”
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Apolipoprotein E epsilon 4 in bulbar-onset motor neuron disease by Smith, R G, Haverkamp, L J, Case, S, Appel, V, Appel, S H

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Biological studies of a putative avian muscle-derived neurotrophic factor that prevents naturally occurring motoneuron death in vivo by Oppenheim, R W, Prevette, D, Haverkamp, L J, Houenou, L, Yin, Q W, McManaman, J

“…A series of in vivo studies have been carried out using the chick embryo to address several critical questions concerning the biological, and to a lesser…”
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Neurotrophic interactions in the development of spinal cord motoneurons by Oppenheim, R W, Haverkamp, L J

“…The final number of spinal cord motoneurons is attained by a two-step process involving the proliferation of precursor cells and the loss by cell death of a…”
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Ontogeny of high- and low-affinity nerve growth factor receptors in the lumbar spinal cord of the developing chick embryo by Marchetti, Dario, Haverkamp, Lanny J., Clark, Robin C., McManaman, James L.

“…The binding of 125I-labeled nerve growth factor-β (NGF) to soluble extracts of intact or dissociated embryonic chick lumbar cords was used to investigate the…”
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Trial of immunosuppression in amyotrophic lateral sclerosis using total lymphoid irradiation by Haverkamp, L J, Smith, R G, Appel, S H

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Developmental discord among markers for cholinergic differentiation: In vitro time courses for early expression and responses to skeletal muscle extract by McManaman, James L., Haverkamp, Lanny J., Appel, Stanley H.

“…The effects of skeletal muscle extract on the development of CAT, ACh synthesis, high affinity choline uptake, and AChE activities were studied in dissociated…”
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A functional framework for neurotrophic activities by Haverkamp, L J

“…In attempts to understand the diverse roles which trophic activities exert in neuronal development and maintenance, it is useful to define some framework from…”
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