Search Results - "HAUSNER, Mary Ann"

Primary, Recall, and Decay Kinetics of SARS-CoV‑2 Vaccine Antibody Responses by Ibarrondo, F. Javier, Hofmann, Christian, Fulcher, Jennifer A, Goodman-Meza, David, Mu, William, Hausner, Mary Ann, Ali, Ayub, Balamurugan, Arumugam, Taus, Ellie, Elliott, Julie, Krogstad, Paul, Tobin, Nicole H, Ferbas, Kathie G, Kitchen, Scott G, Aldrovandi, Grace M, Rimoin, Anne W, Yang, Otto O

“…Studies of two SARS-CoV-2 mRNA vaccines suggested that they yield ∼95% protection from symptomatic infection at least short-term, but important clinical…”
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LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response by Bensinger, Steven J., Bradley, Michelle N., Joseph, Sean B., Zelcer, Noam, Janssen, Edith M., Hausner, Mary Ann, Shih, Roger, Parks, John S., Edwards, Peter A., Jamieson, Beth D., Tontonoz, Peter

“…Cholesterol is essential for membrane synthesis; however, the mechanisms that link cellular lipid metabolism to proliferation are incompletely understood. We…”
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Predominantly defective CD8 + T cell immunity to SARS-CoV-2 mRNA vaccination in lung transplant recipients by Taus, Ellie, Shino, Michael Y, Ibarrondo, F Javier, Hausner, Mary Ann, Hofmann, Christian, Yang, Otto O

“…Although mRNA vaccines have overall efficacy preventing morbidity/mortality from SARS-CoV-2 infection, immunocompromised persons remain at risk. Antibodies…”
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Dominant CD8 + T Cell Nucleocapsid Targeting in SARS-CoV-2 Infection and Broad Spike Targeting From Vaccination by Taus, Ellie, Hofmann, Christian, Ibarrondo, Francisco Javier, Hausner, Mary Ann, Fulcher, Jennifer A, Krogstad, Paul, Ferbas, Kathie G, Tobin, Nicole H, Rimoin, Anne W, Aldrovandi, Grace M, Yang, Otto O

“…CD8 T cells have key protective roles in many viral infections. While an overall Th1-biased cellular immune response against SARS-CoV-2 has been demonstrated,…”
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Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments by Dock, Jeffrey, Ramirez, Christina M, Hultin, Lance, Hausner, Mary Ann, Hultin, Patricia, Elliott, Julie, Yang, Otto O, Anton, Peter A, Jamieson, Beth D, Effros, Rita B

“…A hallmark of human immunosenescence is the accumulation of late-differentiated memory CD8+ T cells with features of replicative senescence, such as inability…”
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Persistent memory despite rapid contraction of circulating T Cell responses to SARS-CoV-2 mRNA vaccination by Taus, Ellie, Hofmann, Christian, Ibarrondo, F Javier, Gong, Laura S, Hausner, Mary Ann, Fulcher, Jennifer A, Krogstad, Paul, Kitchen, Scott G, Ferbas, Kathie G, Tobin, Nicole H, Rimoin, Anne W, Aldrovandi, Grace M, Yang, Otto O

“…While antibodies raised by SARS-CoV-2 mRNA vaccines have had compromised efficacy to prevent breakthrough infections due to both limited durability and spike…”
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The dual impact of HIV-1 infection and aging on naïve CD4 T-cells: additive and distinct patterns of impairment by Rickabaugh, Tammy M, Kilpatrick, Ryan D, Hultin, Lance E, Hultin, Patricia M, Hausner, Mary Ann, Sugar, Catherine A, Althoff, Keri N, Margolick, Joseph B, Rinaldo, Charles R, Detels, Roger, Phair, John, Effros, Rita B, Jamieson, Beth D

“…HIV-1-infected adults over the age of 50 years progress to AIDS more rapidly than adults in their twenties or thirties. In addition, HIV-1-infected individuals…”
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Differential blood and mucosal immune responses against an HIV-1 vaccine administered via inguinal or deltoid injection by Yang, Otto O, Ibarrondo, F Javier, Price, Charles, Hultin, Lance E, Elliott, Julie, Hultin, Patricia M, Shih, Roger, Hausner, Mary Ann, Ng, Hwee L, Hoffman, Jennifer, Jamieson, Beth D, Anton, Peter A

“…Mucosal immunity is central to sexual transmission and overall pathogenesis of HIV-1 infection, but the ability of vaccines to induce immune responses in…”
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Early HLA-B57-Restricted CD8+ T Lymphocyte Responses Predict HIV-1 Disease Progression by BRENNAN, Catherine A, JAVIER IBARRONDO, F, JACOBSON, Lisa P, YANG, Otto O, JAMIESON, Beth D, SUGAR, Catherine A, HAUSNER, Mary Ann, SHIH, Roger, NG, Hwee L, DETELS, Roger, MARGOLICK, Joseph B, RINALDO, Charles R, PHAIR, John

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Parallel Human Immunodeficiency Virus Type 1-Specific CD8+ T-Lymphocyte Responses in Blood and Mucosa during Chronic Infection by IBARRONDO, F. Javier, ANTON, Peter A, HULTIN, Lance E, HULTIN, Patricia M, JAMIESON, Beth D, YANG, Otto O, FUERST, Marie, NG, Hwee L, WONG, Johnson T, MATUD, Jose, ELLIOTT, Julie, SHIH, Roger, HAUSNER, Mary Ann, PRICE, Charles

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Chimeric Antigen Receptors Targeting Human Cytomegalovirus by Ali, Ayub, Chiuppesi, Flavia, Nguyen, Minh, Hausner, Mary Ann, Nguyen, Jenny, Kha, Mindy, Iniguez, Angelina, Wussow, Felix, Diamond, Don J, Yang, Otto O

“…Abstract Human cytomegalovirus (CMV) is a ubiquitous pathogen that causes significant morbidity in some vulnerable populations. Individualized adoptive…”
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Homeostasis of the Naive CD4+ T Cell Compartment during Aging by Kilpatrick, Ryan D, Rickabaugh, Tammy, Hultin, Lance E, Hultin, Patricia, Hausner, Mary Ann, Detels, Roger, Phair, John, Jamieson, Beth D

“…Despite thymic involution, the number of naive CD4(+) T cells diminishes slowly during aging, suggesting considerable peripheral homeostatic expansion of these…”
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Distinct aging profiles of CD8.sup.+ T cells in blood versus gastrointestinal mucosal compartments by Dock, Jeffrey, Ramirez, Christina M, Hultin, Lance, Hausner, Mary Ann, Hultin, Patricia, Elliott, Julie, Yang, Otto O, Anton, Peter A, Jamieson, Beth D, Effros, Rita B

“…A hallmark of human immunosenescence is the accumulation of late-differentiated memory CD8.sup.+ T cells with features of replicative senescence, such as…”
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Differential Blood and Mucosal Immune Responses against an HIV-1 Vaccine Administered via Inguinal or Deltoid Injection: e88621 by Yang, Otto O, Ibarrondo, F Javier, Price, Charles, Hultin, Lance E, Elliott, Julie, Hultin, Patricia M, Shih, Roger, Hausner, Mary Ann, Ng, Hwee L, Hoffman, Jennifer

“…Mucosal immunity is central to sexual transmission and overall pathogenesis of HIV-1 infection, but the ability of vaccines to induce immune responses in…”
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Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis by Effros, R B, Allsopp, R, Chiu, C P, Hausner, M A, Hirji, K, Wang, L, Harley, C B, Villeponteau, B, West, M D, Giorgi, J V

“…To test the hypothesis that the expanded population of non-proliferative CD28-CD8+ T cells in HIV disease have shortened telomeres, thereby providing evidence…”
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Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses by Jamieson, Beth D, Yang, Otto O, Hultin, Lance, Hausner, Mary Ann, Hultin, Patricia, Matud, Jose, Kunstman, Kevin, Killian, Scott, Altman, John, Kommander, Kristina, Korber, Bette, Giorgi, Janis, Wolinsky, Steven

“…To investigate possible mechanisms behind HIV-1 escape from CTL, we performed detailed longitudinal analysis of Gag (SLYNTVATL)- and RT (ILKEPVHGV)-specific…”
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Optimization of methods to assess human mucosal T-cell responses to HIV infection by Shacklett, Barbara L., Yang, Otto, Hausner, Mary Ann, Elliott, Julie, Hultin, Lance, Price, Charles, Fuerst, Marie, Matud, Jose, Hultin, Patricia, Cox, Catherine, Ibarrondo, Javier, Wong, Johnson T., Nixon, Douglas F., Anton, Peter A., Jamieson, Beth D.

“…The majority of HIV-1 infections occur via sexual transmission at mucosal epithelia lining the vagina, cervix or rectum. Mucosal tissues also serve as viral…”
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Homeostasis of the Naive CD4+ T Cell Compartment during Aging1 by Kilpatrick, Ryan D., Rickabaugh, Tammy, Hultin, Lance E., Hultin, Patricia, Hausner, Mary Ann, Detels, Roger, Phair, John, Jamieson, Beth D.

“…Despite thymic involution, the number of naive CD4 + T cells diminishes slowly during aging, suggesting considerable peripheral homeostatic expansion of these…”
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Homeostasis of the Naive CD4 super(+) T Cell Compartment during Aging by Kilpatrick, Ryan D, Rickabaugh, Tammy, Hultin, Lance E, Hultin, Patricia, Hausner, Mary Ann, Detels, Roger, Phair, John, Jamieson, Beth D

“…Despite thymic involution, the number of naive CD4 super(+) T cells diminishes slowly during aging, suggesting considerable peripheral homeostatic expansion of…”
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Differential immunogenicity of vaccinia and HIV-1 components of a human recombinant vaccine in mucosal and blood compartments by Anton, Peter A, Ibarrondo, F. Javier, Boscardin, W. John, Zhou, Ying, Schwartz, Elissa J, Ng, Hwee L, Hausner, Mary Ann, Shih, Roger, Elliott, Julie, Hultin, Patricia M, Hultin, Lance E, Price, Charles, Fuerst, Marie, Adler, Amy, Wong, Johnson T, Yang, Otto O, Jamieson, Beth D

“…Abstract Mucosal immune responses induced by HIV-1 vaccines are likely critical for prevention. We report a Phase 1 safety and immunogenicity trial in eight…”
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