Search Results - "HAUSENLOY, Derek"

Myocardial ischemia-reperfusion injury: a neglected therapeutic target by Hausenloy, Derek J, Yellon, Derek M

“…Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial…”
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Targeting Myocardial Reperfusion Injury — The Search Continues by Hausenloy, Derek J, Yellon, Derek M

“…Timely reperfusion by means of primary percutaneous coronary intervention (PCI) is the most effective therapy for limiting myocardial infarct size in patients…”
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Ischaemic conditioning and reperfusion injury by Hausenloy, Derek J., Yellon, Derek M.

“…Key Points Currently, no treatment has been proven to be effective for preventing 'myocardial reperfusion injury' — the death of cardiomyocytes that…”
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Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning by Ferdinandy, Péter, Hausenloy, Derek J, Heusch, Gerd, Baxter, Gary F, Schulz, Rainer

“…Pre-, post-, and remote conditioning of the myocardium are well described adaptive responses that markedly enhance the ability of the heart to withstand a…”
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The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury by Ong, Sang-Bing, Samangouei, Parisa, Kalkhoran, Siavash Beikoghli, Hausenloy, Derek J

“…Abstract Ischemic heart disease (IHD) remains the leading cause of death and disability worldwide. For patients presenting with an acute myocardial infarction,…”
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Reducing myocardial infarct size: challenges and future opportunities by Bulluck, Heerajnarain, Yellon, Derek M, Hausenloy, Derek J

“…Despite prompt reperfusion by primary percutaneous coronary intervention (PPCI), the mortality and morbidity of patients presenting with an acute ST-segment…”
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Contrast-induced nephropathy following angiography and cardiac interventions by Rear, Roger, Bell, Robert M, Hausenloy, Derek J

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Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease by Nagel, Eike, Greenwood, John P, McCann, Gerry P, Bettencourt, Nuno, Shah, Ajay M, Hussain, Shazia T, Perera, Divaka, Plein, Sven, Bucciarelli-Ducci, Chiara, Paul, Matthias, Westwood, Mark A, Marber, Michael, Richter, Wolf-Stefan, Puntmann, Valentina O, Schwenke, Carsten, Schulz-Menger, Jeanette, Das, Rajiv, Wong, Joyce, Hausenloy, Derek J, Steen, Henning, Berry, Colin

“…Patients with typical angina were randomly assigned to a diagnostic strategy based on cardiovascular MRI or to one based on fractional flow reserve, with…”
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Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology by Sluijter, Joost Petrus Gerardus, Davidson, Sean Michael, Boulanger, Chantal M, Buzás, Edit Iren, de Kleijn, Dominique Paschalis Victor, Engel, Felix Benedikt, Giricz, Zoltán, Hausenloy, Derek J, Kishore, Raj, Lecour, Sandrine, Leor, Jonathan, Madonna, Rosalinda, Perrino, Cinzia, Prunier, Fabrice, Sahoo, Susmita, Schiffelers, Ray Michel, Schulz, Rainer, Van Laake, Linda Wilhelmina, Ytrehus, Kirsti, Ferdinandy, Péter

“…Abstract Extracellular vesicles (EVs)-particularly exosomes and microvesicles (MVs)-are attracting considerable interest in the cardiovascular field as the…”
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Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease by Ong, Sang-Bing, Kalkhoran, Siavash Beikoghli, Cabrera-Fuentes, Hector A., Hausenloy, Derek J.

“…The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics – a phenomenon in which changes in mitochondrial shape…”
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Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities by Ong, Sang-Bing, Hernández-Reséndiz, Sauri, Crespo-Avilan, Gustavo E., Mukhametshina, Regina T., Kwek, Xiu-Yi, Cabrera-Fuentes, Hector A., Hausenloy, Derek J.

“…Acute myocardial infarction (AMI) and the heart failure that often follows, are major causes of death and disability worldwide. As such, new therapies are…”
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Cardiovascular Magnetic Resonance in Acute ST-Segment–Elevation Myocardial Infarction: Recent Advances, Controversies, and Future Directions by Bulluck, Heerajnarain, Dharmakumar, Rohan, Arai, Andrew E, Berry, Colin, Hausenloy, Derek J

“…Although mortality after ST-segment elevation myocardial infarction (MI) is on the decline, the number of patients developing heart failure as a result of MI…”
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Myocardial Reperfusion Injury by Yellon, Derek M, Hausenloy, Derek J

“…Lethal reperfusion injury is a paradoxical type of myocardial injury caused by the restoration of coronary blood flow after an ischemic episode. This review…”
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Oxidative stress in cardiac hypertrophy: From molecular mechanisms to novel therapeutic targets by Ramachandra, Chrishan J.A., Cong, Shuo, Chan, Xavier, Yap, En Ping, Yu, Fan, Hausenloy, Derek J.

“…When faced with increased workload the heart undergoes remodelling, where it increases its muscle mass in an attempt to preserve normal function. This is…”
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The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection by Hausenloy, Derek J, Chilian, William, Crea, Filippo, Davidson, Sean M, Ferdinandy, Peter, Garcia-Dorado, David, van Royen, Niels, Schulz, Rainer, Heusch, Gerd

“…The coronary circulation is both culprit and victim of acute myocardial infarction. The rupture of an epicardial atherosclerotic plaque with superimposed…”
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Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery by Hausenloy, Derek J, Candilio, Luciano, Evans, Richard, Ariti, Cono, Jenkins, David P, Kolvekar, Shyam, Knight, Rosemary, Kunst, Gudrun, Laing, Christopher, Nicholas, Jennifer, Pepper, John, Robertson, Steven, Xenou, Maria, Clayton, Tim, Yellon, Derek M

“…In this multicenter trial, higher-risk adults undergoing on-pump CABG (with or without valve surgery) were randomly assigned to preconditioning with transient…”
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AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury by Marino, Alice, Hausenloy, Derek J., Andreadou, Ioanna, Horman, Sandrine, Bertrand, Luc, Beauloye, Christophe

“…Heart failure is one of the leading causes of death and disability worldwide. Left ventricle remodeling, fibrosis, and ischemia/reperfusion injury all…”
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Discovery of new therapeutic redox targets for cardioprotection against ischemia/reperfusion injury and heart failure by Daiber, Andreas, Andreadou, Ioanna, Oelze, Matthias, Davidson, Sean M., Hausenloy, Derek J.

“…Global epidemiological studies reported a shift from maternal/infectious communicable diseases to chronic non-communicable diseases and a major part is…”
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A future for remote ischaemic conditioning in high-risk patients by Hausenloy, Derek J., Ntsekhe, Mpiko, Yellon, Derek M.

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Cardiac procedural myocardial injury, infarction, and mortality in patients undergoing elective percutaneous coronary intervention: a pooled analysis of patient-level data by Silvain, Johanne, Zeitouni, Michel, Paradies, Valeria, Zheng, Huili L, Ndrepepa, Gjin, Cavallini, Claudio, Feldman, Dimitri N, Sharma, Samin K, Mehilli, Julinda, Gili, Sebastiano, Barbato, Emanuele, Tarantini, Giuseppe, Ooi, Sze Y, von Birgelen, Clemens, Jaffe, Allan S, Thygesen, Kristian, Montalescot, Gilles, Bulluck, Heerajnarain, Hausenloy, Derek J

“…Abstract Aims The prognostic importance of cardiac procedural myocardial injury and myocardial infarction (MI) in chronic coronary syndrome (CCS) patients…”
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