Search Results - "HAUGER, RICHARD L"

African ancestry GWAS of dementia in a large military cohort identifies significant risk loci by Sherva, Richard, Zhang, Rui, Sahelijo, Nathan, Jun, Gyungah, Anglin, Tori, Chanfreau, Catherine, Cho, Kelly, Fonda, Jennifer R., Gaziano, J. Michael, Harrington, Kelly M., Ho, Yuk-Lam, Kremen, William S., Litkowski, Elizabeth, Lynch, Julie, Neale, Zoe, Roussos, Panos, Marra, David, Mez, Jesse, Miller, Mark W., Salat, David H., Tsuang, Debby, Wolf, Erika, Zeng, Qing, Panizzon, Matthew S., Merritt, Victoria C., Farrer, Lindsay A., Hauger, Richard L., Logue, Mark W.

“…While genome wide association studies (GWASs) of Alzheimer’s Disease (AD) in European (EUR) ancestry cohorts have identified approximately 83 potentially…”
Get full text

Role of CRF Receptor Signaling in Stress Vulnerability, Anxiety, and Depression by Hauger, Richard L., Risbrough, Victoria, Oakley, Robert H., Olivares-Reyes, J. Alberto, Dautzenberg, Frank M.

“…Markers of hyperactive central corticotropin releasing factor (CRF) systems and CRF‐related single nucleotide polymorphisms (SNPs) have been identified in…”
Get full text

Interactive effects of testosterone and cortisol on hippocampal volume and episodic memory in middle-aged men by Panizzon, Matthew S., Hauger, Richard L., Xian, Hong, Jacobson, Kristen, Lyons, Michael J., Franz, Carol E., Kremen, William S.

“…•Research suggests that testosterone influences hippocampal structure and function.•The interaction of testosterone with other hormones is rarely…”
Get full text

Genetic variation in human NPY expression affects stress response and emotion by Stohler, Christian S, Zhou, Zhifeng, Hodgkinson, Colin A, Hauger, Richard L, Enoch, Mary-Anne, Ferrell, Robert E, Brown, Sarah M, Hariri, Ahmad R, Yuan, Qiaoping, Goldman, David, Hu, Xian-Zhang, Shen, Pei-Hong, Sinha, Rajita, Lipsky, Robert H, Xu, Ke, Scott, David, Virkkunen, Matti, Mash, Deborah C, Zubieta, Jon-Kar, Buzas, Beata, Manuck, Stephen B, Zhu, Guanshan

“…Understanding inter-individual differences in stress response requires the explanation of genetic influences at multiple phenotypic levels, including complex…”
Get full text

Body mass trajectories and cortical thickness in middle-aged men: a 42-year longitudinal study starting in young adulthood by Franz, Carol E., Xian, Hong, Lew, Daphne, Hatton, Sean N., Puckett, Olivia, Whitsel, Nathan, Beck, Asad, Dale, Anders M., Fang, Bin, Fennema-Notestine, Christine, Hauger, Richard L., Jacobson, Kristen C., Lyons, Michael J., Reynolds, Chandra A., Kremen, William S.

“…Evidence strongly suggests that being overweight or obese at midlife confers significantly higher risk for Alzheimer's disease and greater brain atrophy later…”
Get full text

Mendelian randomization study of diabetes and dementia in the Million Veteran Program by Litkowski, Elizabeth M, Logue, Mark W, Zhang, Rui, Charest, Brian R, Lange, Ethan M, Hokanson, John E, Lynch, Julie A, Vujkovic, Marijana, Phillips, Lawrence S, Hauger, Richard L, Lange, Leslie A, Raghavan, Sridharan

“…Diabetes and dementia are diseases of high health-care burden worldwide. Individuals with diabetes have 1.4 to 2.2 times higher risk of dementia. Our objective…”
Get full text

Relations of combat stress and posttraumatic stress disorder to 24-h plasma and cerebrospinal fluid interleukin-6 levels and circadian rhythmicity by Agorastos, Agorastos, Hauger, Richard L., Barkauskas, Donald A., Lerman, Imanuel R., Moeller-Bertram, Tobias, Snijders, Clara, Haji, Uzair, Patel, Piyush M., Geracioti, Thomas D., Chrousos, George P., Baker, Dewleen G.

“…•First cross-group, time-matched, sequential 24-h plasma and CSF IL-6 sampling study.•No significant group differences in 24-h IL-6 levels in either CSF or…”
Get full text

Association of neurofilament light chain with renal function: mechanisms and clinical implications by Tang, Rongxiang, Panizzon, Matthew S, Elman, Jeremy A, Gillespie, Nathan A, Hauger, Richard L, Rissman, Robert A, Lyons, Michael J, Neale, Michael C, Reynolds, Chandra A, Franz, Carol E, Kremen, William S

“…Blood-based neurofilament light chain (NfL) is a promising biomarker of neurodegeneration across multiple neurodegenerative diseases. However, blood-based NfL…”
Get full text

Effects of Opioid Withdrawal on Psychobiology in People Living with HIV by Grant, Igor, Krupitsky, Evgeny, Vetrova, Marina, Umlauf, Anya, Heaton, Robert K, Hauger, Richard L, Toussova, Olga, Franklin, Donald R, Letendre, Scott L, Woody, George, Blokhina, Elena, Lioznov, Dmitry, Zvartau, Edwin

“…Many persons with opioid use disorders (OUDs) have HIV disease and experience clinically significant stress after they enroll in abstinence-based treatment and…”
Get full text

A 1-week sleep and light intervention improves mood in premenstrual dysphoric disorder in association with shifting melatonin offset time earlier by Parry, Barbara L., Meliska, Charles J., Martinez, L. Fernando, Lopez, Ana M., Sorenson, Diane L., Dawes, Sharron E., Elliott, Jeffrey A., Hauger, Richard L.

“…To test the hypothesis that 1 week of combined sleep and light interventions (SALI), which phase-advance (shift earlier) melatonin circadian rhythms, improves…”
Get full text

Agent orange exposure and prostate cancer risk in the million veteran program by Pagadala, Meghana S, Lui, Asona J, Zhong, Allison Y, Lynch, Julie A, Karunamuni, Roshan, Lee, Kyung Min, Plym, Anna, Rose, Brent S, Carter, Hannah K, Kibel, Adam S, DuVall, Scott L, Gaziano, J Michael, Panizzon, Matthew S, Hauger, Richard L, Seibert, Tyler M

“…The US government considers veterans to have been exposed to Agent Orange if they served in Vietnam while the carcinogen was in use, and these veterans are…”
Get full text

Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy by Hauger, Richard L., Olivares-Reyes, J. Alberto, Dautzenberg, Frank M., Lohr, James B., Braun, Sandra, Oakley, Robert H.

“…The reasons for differences in vulnerability or resilience to the development of posttraumatic stress disorder (PTSD) are unclear. Here we review key genetic…”
Get full text

Are alterations in estradiol, cortisol, and inflammatory cytokines associated with depression during pregnancy and postpartum? An exploratory study by Szpunar, Mercedes J., Malaktaris, Anne, Baca, Selena A., Hauger, Richard L., Lang, Ariel J.

“…Pregnant veterans are a subpopulation known to be at elevated risk of developing mental health symptoms, such as depression and suicidal ideation. Inflammation…”
Get full text

Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men by Agorastos, Agorastos, Hauger, Richard L, Barkauskas, Donald A, Moeller-Bertram, Tobias, Clopton, Paul L, Haji, Uzair, Lohr, James B, Geracioti, Thomas D, Patel, Piyush M, Chrousos, George P, Baker, Dewleen G

“…Summary Background Interleukin-6 (IL-6) is a cytokine with pleiotropic actions in both the periphery of the body and the central nervous system (CNS). Altered…”
Get full text

The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans by Heppner, Pia S, Crawford, Eric F, Haji, Uzair A, Afari, Niloofar, Hauger, Richard L, Dashevsky, Boris A, Horn, Paul S, Nunnink, Sarah E, Baker, Dewleen G

“…There is accumulating evidence for a link between trauma exposure, posttraumatic stress disorder (PTSD) and diminished health status. To assess PTSD-related…”
Get full text

Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging by Franz, Carol E, O’Brien, Robert C, Hauger, Richard L, Mendoza, Sally P, Panizzon, Matthew S, Prom-Wormley, Elizabeth, Eaves, Lindon J, Jacobson, Kristen, Lyons, Michael J, Lupien, Sonia, Hellhammer, Dirk, Xian, Hong, Kremen, William S

“…Summary High levels of cortisol, a sign of potential hypothalamic–pituitary–adrenal (HPA) axis dysregulation, have been associated with poor cognitive outcomes…”
Get full text

International Union of Pharmacology. XXXVI. Current Status of the Nomenclature for Receptors for Corticotropin-Releasing Factor and Their Ligands by Hauger, Richard L, Grigoriadis, Dimitri E, Dallman, Mary F, Plotsky, Paul M, Vale, Wylie W, Dautzenberg, Frank M

“…Receptors for corticotropin-releasing factor (CRF) are members of a family of G protein-coupled receptors (“Family B”) that respond to a variety of…”
Get full text

Composite contributions of cerebrospinal fluid GABAergic neurosteroids, neuropeptide Y and interleukin-6 to PTSD symptom severity in men with PTSD by Kim, Byung Kil, Fonda, Jennifer R., Hauger, Richard L., Pinna, Graziano, Anderson, George M., Valovski, Ivan T., Rasmusson, Ann M.

“…Given that multiple neurobiological systems, as well as components within these systems are impacted by stress, and may interact in additive, compensatory and…”
Get full text

CRF1 Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms by Parra-Mercado, G. Karina, Fuentes-Gonzalez, Alma M., Hernandez-Aranda, Judith, Diaz-Coranguez, Monica, Dautzenberg, Frank M., Catt, Kevin J., Hauger, Richard L., Olivares-Reyes, J. Alberto

“…In the present study, we determined the cellular regulators of ERK1/2 and Akt signaling pathways in response to human CRF 1 receptor (CRF 1 R) activation in…”
Get full text

Associations between PTSD-Related extinction retention deficits in women and plasma steroids that modulate brain GABAA and NMDA receptor activity by Pineles, Suzanne L., Nillni, Yael I., Pinna, Graziano, Webb, Andrea, Arditte Hall, Kimberly A., Fonda, Jennifer R., Irvine, John, King, Matthew W., Hauger, Richard L., Resick, Patricia A., Orr, Scott P., Rasmusson, Ann M.

“…Several studies have demonstrated poor retention of extinction learning among individuals with posttraumatic stress disorder (PTSD). Gonadal hormone signaling…”
Get full text