Search Results - "HATHOUT, Yetrib"

Approaches to the study of the cell secretome by Hathout, Yetrib

“…The secretome, or secretomics, has recently emerged as a new term to describe the global study of proteins that are secreted by a cell, tissue or organism at…”
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Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy by Hathout, Yetrib, Brody, Edward, Clemens, Paula R., Cripe, Linda, DeLisle, Robert Kirk, Furlong, Pat, Gordish-Dressman, Heather, Hache, Lauren, Henricson, Erik, Hoffman, Eric P., Kobayashi, Yvonne Monique, Lorts, Angela, Mah, Jean K., McDonald, Craig, Mehler, Bob, Nelson, Sally, Nikrad, Malti, Singer, Britta, Steele, Fintan, Sterling, David, Sweeney, H. Lee, Williams, Steve, Gold, Larry

“…Significance Duchenne muscular dystrophy (DMD) is a rare and devastating muscle disease caused by mutations in the X-linked DMD gene (which encodes the…”
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Proteomic and Bioinformatic Analysis of Decellularized Pancreatic Extracellular Matrices by Hu, Ming, Bi, Huanjing, Moffat, Deana, Blystone, Margaret, DeCostanza, Lillian, Alayi, Tchilabalo, Ye, Kaiming, Hathout, Yetrib, Jin, Sha

“…Tissue microenvironments are rich in signaling molecules. However, factors in the tissue matrix that can serve as tissue-specific cues for engineering…”
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Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients by Hathout, Yetrib, Marathi, Ramya L, Rayavarapu, Sree, Zhang, Aiping, Brown, Kristy J, Seol, Haeri, Gordish-Dressman, Heather, Cirak, Sebahattin, Bello, Luca, Nagaraju, Kanneboyina, Partridge, Terry, Hoffman, Eric P, Takeda, Shin'ichi, Mah, Jean K, Henricson, Erik, McDonald, Craig

“…It is expected that serum protein biomarkers in Duchenne muscular dystrophy (DMD) will reflect disease pathogenesis, progression and aid future therapy…”
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Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice by Ziemba, Michael, Barkhouse, Molly, Uaesoontrachoon, Kitipong, Giri, Mamta, Hathout, Yetrib, Dang, Utkarsh J, Gordish-Dressman, Heather, Nagaraju, Kanneboyina, Hoffman, Eric P

“…Duchenne muscular dystrophy is initiated by dystrophin deficiency, but downstream pathophysiological pathways such as membrane instability, NFĸB activation,…”
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miR‐184 regulates ezrin, LAMP‐1 expression, affects phagocytosis in human retinal pigment epithelium and is downregulated in age‐related macular degeneration by Murad, Najiba, Kokkinaki, Maria, Gunawardena, Nishantha, Gunawan, Mia S, Hathout, Yetrib, Janczura, Karolina J, Theos, Alexander C, Golestaneh, Nady

“…MicroRNA 184 (miR‐184) is known to play a key role in neurological development and apoptosis and is highly expressed in mouse brain, mouse corneal epithelium,…”
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Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome by An, Eunkyung, Sen, Supti, Park, Sung Kyu, Gordish-Dressman, Heather, Hathout, Yetrib

“…PURPOSE. To define the role of the serine protease HTRA1 in age-related macular degeneration (AMD) by examining its expression level and identifying its…”
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Toxoplasma membrane inositol phospholipid binding protein TgREMIND is essential for secretory organelle function and host infection by Houngue, Rodrigue, Sangaré, Lamba Omar, Alayi, Tchilabalo Dilezitoko, Dieng, Aissatou, Bitard-Feildel, Tristan, Boulogne, Claire, Slomianny, Christian, Atindehou, Cynthia Menonve, Fanou, Lucie Ayi, Hathout, Yetrib, Callebaut, Isabelle, Tomavo, Stanislas

“…Apicomplexan parasites possess specialized secretory organelles called rhoptries, micronemes, and dense granules that play a vital role in host infection. In…”
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Creation and characterization of an immortalized canine myoblast cell line: Myok9 by López, Sara Mata, Balog-Alvarez, Cynthia, Canessa, Emily H., Hathout, Yetrib, Brown, Kristy J., Vitha, Stanislav, Bettis, Amanda K., Boehler, Jessica, Kornegay, Joe N., Nghiem, Peter P.

“…The availability of an in vitro canine cell line would reduce the need for dogs for primary in vitro cell culture and reduce overall cost in pre-clinical…”
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Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle by Novak, James S., Hogarth, Marshall W., Boehler, Jessica F., Nearing, Marie, Vila, Maria C., Heredia, Raul, Fiorillo, Alyson A., Zhang, Aiping, Hathout, Yetrib, Hoffman, Eric P., Jaiswal, Jyoti K., Nagaraju, Kanneboyina, Cirak, Sebahattin, Partridge, Terence A.

“…Exon skipping is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD), employing morpholino antisense oligonucleotides (PMO-AO) to exclude…”
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Identification of Disease Specific Pathways Using in Vivo SILAC Proteomics in Dystrophin Deficient mdx Mouse by Rayavarapu, Sree, Coley, William, Cakir, Erdinc, Jahnke, Vanessa, Takeda, Shin'ichi, Aoki, Yoshitsugu, Grodish-Dressman, Heather, Jaiswal, Jyoti K., Hoffman, Eric P., Brown, Kristy J., Hathout, Yetrib, Nagaraju, Kanneboyina

“…Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disorder caused by a mutation in the dystrophin gene. DMD is characterized by progressive…”
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Title-molecular diagnostics of dystrophinopathies in Sri Lanka towards phenotype predictions: an insight from a South Asian resource limited setting by Wijekoon, Nalaka, Gonawala, Lakmal, Ratnayake, Pyara, Liyanage, Roshan, Amaratunga, Dhammika, Hathout, Yetrib, Steinbusch, Harry W M, Dalal, Ashwin, Hoffman, Eric P, de Silva, K Ranil D

“…The phenotype of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) patients is determined by the type of DMD gene variation, its location,…”
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Dystrophin deficiency leads to disturbance of LAMP1-vesicle-associated protein secretion by Duguez, Stephanie, Duddy, William, Johnston, Helen, Lainé, Jeanne, Le Bihan, Marie Catherine, Brown, Kristy J., Bigot, Anne, Hathout, Yetrib, Butler-Browne, Gillian, Partridge, Terence

“…Duchenne muscular dystrophy results from loss of the protein dystrophin, which links the intracellular cytoskeletal network with the extracellular matrix, but…”
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Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children by Hathout, Yetrib, Conklin, Laurie S., Seol, Haeri, Gordish-Dressman, Heather, Brown, Kristy J., Morgenroth, Lauren P., Nagaraju, Kanneboyina, Heier, Christopher R., Damsker, Jesse M., van den Anker, John N., Henricson, Erik, Clemens, Paula R., Mah, Jean K., McDonald, Craig, Hoffman, Eric P.

“…Corticosteroids are extensively used in pediatrics, yet the burden of side effects is significant. Availability of a simple, fast and reliable biochemical read…”
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Use of Quantitative Membrane Proteomics Identifies a Novel Role of Mitochondria in Healing Injured Muscles by Sharma, Nimisha, Medikayala, Sushma, Defour, Aurelia, Rayavarapu, Sree, Brown, Kristy J., Hathout, Yetrib, Jaiswal, Jyoti K.

“…Skeletal muscles are proficient at healing from a variety of injuries. Healing occurs in two phases, early and late phase. Early phase involves healing the…”
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Discovery of potential urine-accessible metabolite biomarkers associated with muscle disease and corticosteroid response in the mdx mouse model for Duchenne by Thangarajh, Mathula, Zhang, Aiping, Gill, Kirandeep, Ressom, Habtom W, Li, Zhenzhi, Varghese, Rency S, Hoffman, Eric P, Nagaraju, Kanneboyina, Hathout, Yetrib, Boca, Simina M

“…Urine is increasingly being considered as a source of biomarker development in Duchenne Muscular Dystrophy (DMD), a severe, life-limiting disorder that affects…”
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Morpholino‐induced exon skipping stimulates cell‐mediated and humoral responses to dystrophin in mdx mice by Vila, Maria C, Novak, James S, Benny Klimek, Margaret, Li, Ning, Morales, Melissa, Fritz, Alexander G, Edwards, Katie, Boehler, Jessica F, Hogarth, Marshall W, Kinder, Travis B, Zhang, Aiping, Mazala, Davi, Fiorillo, Alyson A, Douglas, Bonnie, Chen, Yi‐Wen, van den Anker, John, Lu, Qi L, Hathout, Yetrib, Hoffman, Eric P, Partridge, Terence A, Nagaraju, Kanneboyina

“…Exon skipping is a promising genetic therapeutic strategy for restoring dystrophin expression in the treatment of Duchenne muscular dystrophy (DMD). The…”
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Advances in the proteomic investigation of the cell secretome by Brown, Kristy J, Formolo, Catherine A, Seol, Haeri, Marathi, Ramya L, Duguez, Stephanie, An, Eunkyung, Pillai, Dinesh, Nazarian, Javad, Rood, Brian R, Hathout, Yetrib

“…Studies of the cell secretome have greatly increased in recent years owing to improvements in proteomic platforms, mass spectrometry instrumentation and to the…”
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Discovery of Metabolic Biomarkers for Duchenne Muscular Dystrophy within a Natural History Study by Boca, Simina M, Nishida, Maki, Harris, Michael, Rao, Shruti, Cheema, Amrita K, Gill, Kirandeep, Seol, Haeri, Morgenroth, Lauren P, Henricson, Erik, McDonald, Craig, Mah, Jean K, Clemens, Paula R, Hoffman, Eric P, Hathout, Yetrib, Madhavan, Subha

“…Serum metabolite profiling in Duchenne muscular dystrophy (DMD) may enable discovery of valuable molecular markers for disease progression and treatment…”
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Clinical utility of serum biomarkers in Duchenne muscular dystrophy by Hathout, Yetrib, Seol, Haeri, Han, Meng Hsuan J, Zhang, Aiping, Brown, Kristy J, Hoffman, Eric P

“…Assessments of disease progression and response to therapies in Duchenne muscular dystrophy (DMD) patients remain challenging. Current DMD patient assessments…”
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