Search Results - "HATANAKA, Kentaro"

Characterizing an siRNA-Containing Lipid-Nanoparticle Prepared by a Microfluidic Reactor: Small-Angle X‑ray Scattering and Cryotransmission Electron Microscopic Studies by Aburai, Kenichi, Hatanaka, Kentaro, Takano, Shin, Fujii, Shota, Sakurai, Kazuo

“…A new cationic-lipid/siRNA particle that was designed to deliver siRNA was investigated by the combination of small-angle X-ray scattering (SAXS), asymmetric…”
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Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis by Mukai, Hidefumi, Hatanaka, Kentaro, Yagi, Nobuhiro, Warashina, Shota, Zouda, Maki, Takahashi, Maiko, Narushima, Kazuya, Yabuuchi, Hayato, Iwano, Junko, Kuboyama, Takeshi, Enokizono, Junichi, Wada, Yasuhiro, Watanabe, Yasuyoshi

“…In vivo biodistribution analyses, especially in tumors, of nucleic acids delivered with nanoparticles are important to develop drug delivery technologies for…”
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Systemic Delivery of Small Interfering RNA by Use of Targeted Polycation Liposomes for Cancer Therapy by Kenjo, Eriya, Asai, Tomohiro, Yonenaga, Norihito, Ando, Hidenori, Ishii, Takayuki, Hatanaka, Kentaro, Shimizu, Kosuke, Urita, Yugo, Dewa, Takehisa, Nango, Mamoru, Tsukada, Hideo, Oku, Naoto

“…Novel polycation liposomes decorated with cyclic(Cys-Arg-Gly-Asp-D-Phe) peptide (cyclicRGD)-polyethylene glycol (PEG) (RGD-PEG-polycation liposomes (PCL)) were…”
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Dynamic Analysis of Fluid Distribution in the Gastrointestinal Tract in Rats: Positron Emission Tomography Imaging after Oral Administration of Nonabsorbable Marker, [18F]Deoxyfluoropoly(ethylene glycol) by Takashima, Tadayuki, Shingaki, Tomotaka, Katayama, Yumiko, Hayashinaka, Emi, Wada, Yasuhiro, Kataoka, Makoto, Ozaki, Daiki, Doi, Hisashi, Suzuki, Masaaki, Ishida, Sho, Hatanaka, Kentaro, Sugiyama, Yuichi, Akai, Shuji, Oku, Naoto, Yamashita, Shinji, Watanabe, Yasuyoshi

“…To develop potent drugs for oral use, information on their pharmacokinetic (PK) properties after oral administration is of great importance. We have recently…”
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Synthesis and evaluation of a novel lipid–peptide conjugate for functionalized liposome by Yagi, Nobuhiro, Yano, Yuko, Hatanaka, Kentaro, Yokoyama, Yuusaku, Okuno, Hiroaki

“…A convenient synthetic route for novel lipopeptide modified with TAT has been established, and functionalized liposome was successfully prepared and…”
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In Vivo Distribution of Liposome-Encapsulated Hemoglobin Determined by Positron Emission Tomography by Urakami, Takeo, Kawaguchi, Akira T., Akai, Shuji, Hatanaka, Kentaro, Koide, Hiroyuki, Shimizu, Kosuke, Asai, Tomohiro, Fukumoto, Dai, Harada, Norihiro, Tsukada, Hideo, Oku, Naoto

“…Positron emission tomography (PET) is a noninvasive imaging technology that enables the determination of biodistribution of positron emitter‐labeled compounds…”
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Antineovascular therapy with angiogenic vessel‐targeted polyethyleneglycol‐shielded liposomal DPP–CNDAC by Asai, Tomohiro, Miyazawa, Souichiro, Maeda, Noriyuki, Hatanaka, Kentaro, Katanasaka, Yasufumi, Shimizu, Kosuke, Shuto, Satoshi, Oku, Naoto

“…Causing damage to angiogenic vessels is a promising approach for cancer chemotherapy. The present study is a codification of a designed liposomal drug delivery…”
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Forefront of drug delivery system research: novel technologies used in various fields by Hatanaka, Kentaro, Kamei, Noriyasu

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Antineovascular Gene Therapy by Ago2 Knockdown by HATANAKA, Kentaro, SHIMIZU, Kosuke, ASAI, Tomohiro, OKU, Naoto

“…Small interfering RNA (siRNA), which induces sequence-dependent gene silencing, has been widely studied. We previously developed polycation liposomes (PCL) as…”
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T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes by Koide, Hiroyuki, Asai, Tomohiro, Hatanaka, Kentaro, Akai, Shuji, Ishii, Takayuki, Kenjo, Eriya, Ishida, Tatsuhiro, Kiwada, Hiroshi, Tsukada, Hideo, Oku, Naoto

“…Repeated injection of polyethyleneglycol-modified (PEGylated) liposomes causes a rapid clearance of them from the bloodstream, this phenomenon is called…”
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Particle size-dependent triggering of accelerated blood clearance phenomenon by Koide, Hiroyuki, Asai, Tomohiro, Hatanaka, Kentaro, Urakami, Takeo, Ishii, Takayuki, Kenjo, Eriya, Nishihara, Masamichi, Yokoyama, Masayuki, Ishida, Tatsuhiro, Kiwada, Hiroshi, Oku, Naoto

“…A repeat-injection of polyethylene glycol-modified liposomes (PEGylated liposomes) causes a rapid clearance of them from the blood circulation in certain cases…”
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RNA創薬研究におけるポジトロン標識small interfering RNA (siRNA) の positron emission tomography (PET) 体内動態イメージング by 安藤, 英紀, 米永, 憲史, 浅井, 知浩, 畑中, 剣太朗, 小出, 裕之, 都竹, 拓磨, 原田, 典弘, 塚田, 秀夫, 奥, 直人

“…「1. はじめに」small interfering RNA(siRNA)は, 21-23塩基対の2本鎖核酸分子であり, 配列特異的な遺伝子サイレンシングを引き起こすことから, 1,2)遺伝子疾患や難治性疾患を始めとする, 今まで治療が困難であった様々な疾患に対する新規治療薬として, 近年大きな注目を集めている3)…”
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PET imaging of brain cancer with positron emitter-labeled liposomes by Oku, Naoto, Yamashita, Mina, Katayama, Yurie, Urakami, Takeo, Hatanaka, Kentaro, Shimizu, Kosuke, Asai, Tomohiro, Tsukada, Hideo, Akai, Shuji, Kanazawa, Hiroaki

“…Since nanocarriers such as liposomes are known to accumulate in tumors of tumor-bearing animals, and those that have entrapped a positron emitter can be used…”
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多分野で応用される新規DDS技術 by 畑中, 剣太朗, 亀井, 敬泰

“…薬物送達システム(drug delivery system；DDS)は, 薬物の送達効率を向上させることで薬効の増強, 薬理作用の分離, 副作用の軽減, 安全性の向上, 使用性の改善や事業性・経済性の向上, 開発リスクの軽減, バイオ製剤技術への応用・実用化を可能とし, 多岐に渡り医薬品創製研究に貢献している…”
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Development of Double-Stranded siRNA Labeling Method Using Positron Emitter and Its In Vivo Trafficking Analyzed by Positron Emission Tomography by Hatanaka, Kentaro, Asai, Tomohiro, Koide, Hiroyuki, Kenjo, Eriya, Tsuzuku, Takuma, Harada, Norihiro, Tsukada, Hideo, Oku, Naoto

“…Pharmacokinetic study of small interfering RNA (siRNA) is an important issue for the development of siRNAs for use as a medicine. For this purpose, a novel and…”
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Dicetyl Phosphate-Tetraethylenepentamine-Based Liposomes for Systemic siRNA Delivery by Asai, Tomohiro, Matsushita, Saori, Kenjo, Eriya, Tsuzuku, Takuma, Yonenaga, Norihito, Koide, Hiroyuki, Hatanaka, Kentaro, Dewa, Takehisa, Nango, Mamoru, Maeda, Noriyuki, Kikuchi, Hiroshi, Oku, Naoto

“…Dicetyl phosphate-tetraethylenepentamine (DCP-TEPA) conjugate was newly synthesized and formed into liposomes for efficient siRNA delivery. Formulation of…”
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Argonaute2 ノックダウンによる腫瘍新生血管傷害療法の開発 by 畑中, 剣太朗, 清水, 広介, 浅井, 知浩, 奥, 直人

“…「1. はじめに」 プラスミドDNA, アンチセンスオリゴヌクレオチド, small interfering RNA(siRNA)などの核酸は次世代の医薬品シーズとして有望視されている. 中でもsiRNAは, わずか20数塩基対の二本鎖RNA(double-stranded RNA：dsRNA)であるが,…”
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PEG化ナノキャリア頻回投与によるaccelerated blood clearance現象の機構解明 by 小出, 裕之, 浅井, 知浩, 畑中, 剣太朗, 清水, 広介, 横山, 昌幸, 石田, 竜弘, 際田, 弘志, 奥, 直人

“…「1. はじめに」リポソームは, 生体の細胞膜を構成しているリン脂質からなる人工細胞様微粒子である. したがって, 生体適合性が高く, 体内では薬物を分解酵素などから保護しながら運搬できるため, 理想的なDDS運搬体と考えられている. 薬物をリポソーム内に封入することによって, 副作用を軽減でき,…”
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Synthesis of Long-Chain [18F]Deoxyfluoropoly(ethylene glycol) Methyl Ethers and Their Noninvasive Pharmacokinetic Analysis by Positron Emission Tomography by Akai, Shuji, Ishida, Sho, Hatanaka, Kentaro, Ishii, Takayuki, Harada, Norihiro, Tsukada, Hideo, Oku, Naoto

“…[18F]DeoxyfluoroPEG methyl ethers with an average molecular weight of 2 kDa ([18F]1a) and 10 kDa ([18F]1b) were synthesized by the fluorination of the…”
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In Vivo Imaging of Liposomal Small Interfering RNA (siRNA) Trafficking by Positron Emission Tomography by Ando, Hidenori, Yonenaga, Norihito, Asai, Tomohiro, Hatanaka, Kentaro, Koide, Hiroyuki, Tsuzuku, Takuma, Harada, Norihiro, Tsukada, Hideo, Oku, Naoto

“…In the development of nucleic acid medicines such as small interfering RNA (siRNA) drugs, one problem is how to study the pharmacokinetics and…”
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