Search Results - "HATAKEYAMA, KEIICHI"

Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line by Ohshima, Keiichi, Inoue, Kanako, Fujiwara, Akemi, Hatakeyama, Keiichi, Kanto, Kaori, Watanabe, Yuko, Muramatsu, Koji, Fukuda, Yorikane, Ogura, Shun-ichiro, Yamaguchi, Ken, Mochizuki, Tohru

“…Exosomes play a major role in cell-to-cell communication, targeting cells to transfer exosomal molecules including proteins, mRNAs, and microRNAs (miRNAs) by…”
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Molecular classification of gastric cancer predicts survival in patients undergoing radical gastrectomy based on project HOPE by Furukawa, Kenichiro, Hatakeyama, Keiichi, Terashima, Masanori, Nagashima, Takeshi, Urakami, Kenichi, Ohshima, Keiichi, Notsu, Akifumi, Sugino, Takashi, Yagi, Taisuke, Fujiya, Keiichi, Kamiya, Satoshi, Hikage, Makoto, Tanizawa, Yutaka, Bando, Etsuro, Kanai, Yae, Akiyama, Yasuto, Yamaguchi, Ken

“…Background Gastric cancer (GC) has been classified based on molecular profiling like The Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG), and…”
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Molecular features and prognostic factors of locally advanced microsatellite instability-high gastric cancer by Furukawa, Kenichiro, Hatakeyama, Keiichi, Terashima, Masanori, Urakami, Kenichi, Koseki, Yusuke, Fujiya, Keiichi, Tanizawa, Yutaka, Bando, Etsuro, Yamaguchi, Ken

“…Background Microsatellite instability-high (MSI-H) tumors are distinct molecular subtypes in gastric cancer. However, a few studies have comprehensively…”
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Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors by Ohshima, Keiichi, Hatakeyama, Keiichi, Nagashima, Takeshi, Watanabe, Yuko, Kanto, Kaori, Doi, Yuki, Ide, Tomomi, Shimoda, Yuji, Tanabe, Tomoe, Ohnami, Sumiko, Ohnami, Shumpei, Serizawa, Masakuni, Maruyama, Koji, Akiyama, Yasuto, Urakami, Kenichi, Kusuhara, Masatoshi, Mochizuki, Tohru, Yamaguchi, Ken

“…Identification of driver genes contributes to the understanding of cancer etiology and is imperative for the development of individualized therapies. Gene…”
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Driver gene alterations and activated signaling pathways toward malignant progression of gastrointestinal stromal tumors by Ohshima, Keiichi, Fujiya, Keiichi, Nagashima, Takeshi, Ohnami, Sumiko, Hatakeyama, Keiichi, Urakami, Kenichi, Naruoka, Akane, Watanabe, Yuko, Moromizato, Sachi, Shimoda, Yuji, Ohnami, Shumpei, Serizawa, Masakuni, Akiyama, Yasuto, Kusuhara, Masatoshi, Mochizuki, Tohru, Sugino, Takashi, Shiomi, Akio, Tsubosa, Yasuhiro, Uesaka, Katsuhiko, Terashima, Masanori, Yamaguchi, Ken

“…Mutually exclusive KIT and PDGFRA mutations are considered to be the earliest events in gastrointestinal stromal tumors (GIST), but insufficient for their…”
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Tumor cell enrichment by tissue suspension enables detection of mutations with low variant allele frequency and estimation of germline mutations by Hatakeyama, Keiichi, Muramatsu, Koji, Nagashima, Takeshi, Kawanishi, Yuichi, Fukumura, Ryutaro, Ohshima, Keiichi, Shimoda, Yuji, Kenmotsu, Hirotsugu, Mochizuki, Tohru, Urakami, Kenichi, Akiyama, Yasuto, Sugino, Takashi, Yamaguchi, Ken

“…Targeted sequencing offers an opportunity to select specific drugs for cancer patients based on alterations in their genome. However, accurate sequencing…”
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Molecular profile of poorly cohesive gastric carcinoma with special reference to survival by Koseki, Yusuke, Hatakeyama, Keiichi, Terashima, Masanori, Nagashima, Takeshi, Urakami, Kenichi, Ohshima, Keiichi, Aizawa, Daisuke, Sugino, Takashi, Furukawa, Kenichiro, Fujiya, Keiichi, Tanizawa, Yutaka, Bando, Etsuro, Okamura, Yukiyasu, Akiyama, Yasuto, Yamaguchi, Ken

“…Background Patients with poorly cohesive gastric carcinoma (PCC) are known to have poor survival. However, detailed molecular biology of PCC has not been…”
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Japanese version of The Cancer Genome Atlas, JCGA, established using fresh frozen tumors obtained from 5143 cancer patients by Nagashima, Takeshi, Yamaguchi, Ken, Urakami, Kenichi, Shimoda, Yuji, Ohnami, Sumiko, Ohshima, Keiichi, Tanabe, Tomoe, Naruoka, Akane, Kamada, Fukumi, Serizawa, Masakuni, Hatakeyama, Keiichi, Matsumura, Kenya, Ohnami, Shumpei, Maruyama, Koji, Mochizuki, Tohru, Kusuhara, Masatoshi, Shiomi, Akio, Ohde, Yasuhisa, Terashima, Masanori, Uesaka, Katsuhiko, Onitsuka, Tetsuro, Nishimura, Seiichiro, Hirashima, Yasuyuki, Hayashi, Nakamasa, Kiyohara, Yoshio, Tsubosa, Yasuhiro, Katagiri, Hirohisa, Niwakawa, Masashi, Takahashi, Kaoru, Kashiwagi, Hiroya, Nakagawa, Masahiro, Ishida, Yuji, Sugino, Takashi, Takahashi, Mitsuru, Akiyama, Yasuto

“…This study aimed to establish the Japanese Cancer Genome Atlas (JCGA) using data from fresh frozen tumor tissues obtained from 5143 Japanese cancer patients,…”
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MAGEA10 expression is a predictive marker of early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer by Fujiya, Keiichi, Terashima, Masanori, Ohshima, Keiichi, Aizawa, Daisuke, Sugino, Takashi, Serizawa, Masakuni, Nakamura, Kenichi, Nagashima, Takeshi, Hatakeyama, Keiichi, Urakami, Kenichi, Akiyama, Yasuto, Tsubosa, Yasuhiro, Kitagawa, Yuko, Yamaguchi, Ken

“…Background Resection for hepatic recurrence after gastrectomy in patients with gastric cancer may be curative; however, the prediction of hepatic recurrence…”
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Contributions of Phosphate to DNA Adsorption/Desorption Behaviors on Aminosilane-Modified Magnetic Nanoparticles by Tanaka, Tsuyoshi, Sakai, Ririko, Kobayashi, Ryosuke, Hatakeyama, Keiichi, Matsunaga, Tadashi

“…The adsorption and desorption behaviors of DNA on aminosilane-modified magnetic nanoparticles were investigated by altering both type of anions and solvation…”
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BMP4 and PHLDA1 are plausible drug-targetable candidate genes for KRAS G12A-, G12D-, and G12V-driven colorectal cancer by Ohnami, Shumpei, Maruyama, Kouji, Chen, Kai, Takahashi, Yu, Hatakeyama, Keiichi, Ohshima, Keiichi, Shimoda, Yuji, Sakai, Ai, Kamada, Fukumi, Nakatani, Sou, Naruoka, Akane, Ohnami, Sumiko, Kusuhara, Masatoshi, Akiyama, Yasuto, Kagawa, Hiroyasu, Shiomi, Akio, Nagashima, Takeshi, Urakami, Kenichi, Yamaguchi, Ken

“…Despite the frequent detection of KRAS driver mutations in patients with colorectal cancer (CRC), no effective treatments that target mutant KRAS proteins have…”
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Characterization of pancreatic cancer with ultra-low tumor mutational burden by Imamura, Taisuke, Ashida, Ryo, Ohshima, Keiichi, Uesaka, Katsuhiko, Sugiura, Teiichi, Ohgi, Katsuhisa, Yamada, Mihoko, Otsuka, Shimpei, Hatakeyama, Keiichi, Nagashima, Takeshi, Sugino, Takashi, Urakami, Kenichi, Akiyama, Yasuto, Yamaguchi, Ken

“…In pancreatic cancer (PC), Tumor mutation burden (TMB) has been reported to be lower than in other cancers, with its clinical significance remaining unclear…”
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Consensus molecular subtyping improves the clinical usefulness of canonical tumor markers for colorectal cancer by Kagawa, Hiroyasu, Hatakeyama, Keiichi, Shiomi, Akio, Hino, Hitoshi, Manabe, Shoichi, Yamaoka, Yusuke, Nagashima, Takeshi, Ohshima, Keiichi, Urakami, Kenichi, Yamaguchi, Ken

“…Transcriptome-based classification, such as consensus molecular subtyping, is expected to be applied to colorectal cancer (CRC). However, the relationship…”
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Mutational burden and signatures in 4000 Japanese cancers provide insights into tumorigenesis and response to therapy by Hatakeyama, Keiichi, Nagashima, Takeshi, Ohshima, Keiichi, Ohnami, Sumiko, Ohnami, Shumpei, Shimoda, Yuji, Serizawa, Masakuni, Maruyama, Koji, Naruoka, Akane, Akiyama, Yasuto, Urakami, Kenichi, Kusuhara, Masatoshi, Mochizuki, Tohru, Yamaguchi, Ken

“…Tumor mutational burden (TMB) and mutational signatures reflect the process of mutation accumulation in cancer. However, the significance of these emerging…”
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Tumor cell enrichment by tissue suspension improves sensitivity to copy number variation in diffuse gastric cancer with low tumor content by Hatakeyama, Keiichi, Muramatsu, Koji, Nagashima, Takeshi, Ichida, Hiroyuki, Kawanishi, Yuichi, Fukumura, Ryutaro, Ohshima, Keiichi, Shimoda, Yuji, Ohnami, Sumiko, Ohnami, Shumpei, Maruyama, Koji, Naruoka, Akane, Kenmotsu, Hirotsugu, Urakami, Kenichi, Akiyama, Yasuto, Sugino, Takashi, Yamaguchi, Ken

“…The detection of copy number variations (CNVs) and somatic mutations in cancer is important for the selection of specific drugs for patients with cancer. In…”
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Characterization of tumors with ultralow tumor mutational burden in Japanese cancer patients by Hatakeyama, Keiichi, Nagashima, Takeshi, Ohshima, Keiichi, Ohnami, Sumiko, Ohnami, Shumpei, Shimoda, Yuji, Naruoka, Akane, Maruyama, Koji, Iizuka, Akira, Ashizawa, Tadashi, Mochizuki, Tohru, Urakami, Kenichi, Akiyama, Yasuto, Yamaguchi, Ken

“…Tumor mutational burden analysis using whole‐exome sequencing highlights features of tumors with various mutations or known driver alterations. Cancers with…”
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Prediction of S-1 adjuvant chemotherapy benefit in Stage II/III gastric cancer treatment based on comprehensive gene expression analysis by Nakamura, Kenichi, Hatakeyama, Keiichi, Furukawa, Kenichiro, Fujiya, Keiichi, Kamiya, Satoshi, Hikage, Makoto, Tanizawa, Yutaka, Bando, Etsuro, Ohshima, Keiichi, Urakami, Kenichi, Machida, Nozomu, Yasui, Hirofumi, Yamaguchi, Ken, Terashima, Masanori

“…Background Studies to identify predictive biomarkers of adjuvant chemotherapy with S-1 after gastrectomy in Stage II/III gastric cancer patients have been…”
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Comprehensive genetic characterization of rectal cancer in a large cohort of Japanese patients: differences according to tumor location by Hino, Hitoshi, Shiomi, Akio, Hatakeyama, Keiichi, Kagawa, Hiroyasu, Manabe, Shoichi, Yamaoka, Yusuke, Nagashima, Takeshi, Ohshima, Keiichi, Urakami, Kenichi, Akiyama, Yasuto, Yamaguchi, Ken

“…Background In clinical practice, rectal cancer (RC) is classified according to tumor location. However, RC’s genetic characteristics according to tumor…”
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Characterization of rare histological subtypes of ovarian cancer based on molecular profiling by Takahashi, Nobutaka, Hatakeyama, Keiichi, Nagashima, Takeshi, Ohshima, Keiichi, Urakami, Kenichi, Yamaguchi, Ken, Hirashima, Yasuyuki

“…Objective Pan‐cancer analysis across The Cancer Genome Atlas has revealed the molecular profiles of major types of carcinomas. High‐grade serous carcinomas…”
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Overview and clinical significance of multiple mutations in individual genes in hepatocellular carcinoma by Imamura, Taisuke, Okamura, Yukiyasu, Ohshima, Keiichi, Uesaka, Katsuhiko, Sugiura, Teiichi, Ito, Takaaki, Yamamoto, Yusuke, Ashida, Ryo, Ohgi, Katsuhisa, Otsuka, Shimpei, Ohnami, Sumiko, Nagashima, Takeshi, Hatakeyama, Keiichi, Sugino, Takashi, Urakami, Kenichi, Akiyama, Yasuto, Yamaguchi, Ken

“…Background Multiple mutation (MM) within a single gene has recently been reported as a mechanism involved in carcinogenesis. The present study investigated the…”
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