Search Results - "HASTY, Alyssa H"

Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice by Cottam, Matthew A., Caslin, Heather L., Winn, Nathan C., Hasty, Alyssa H.

“…Within adipose tissue (AT), immune cells and parenchymal cells closely interact creating a complex microenvironment. In obesity, immune cell derived…”
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Macrophage-Targeted Therapeutics for Metabolic Disease by Peterson, Kristin R., Cottam, Matthew A., Kennedy, Arion J., Hasty, Alyssa H.

“…Macrophages are cells of the innate immune system that are resident in all tissues, including metabolic organs such as the liver and adipose tissue (AT)…”
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A decade of progress in adipose tissue macrophage biology by Hill, Andrea A., Reid Bolus, W., Hasty, Alyssa H.

“…Summary One decade has passed since seminal publications described macrophage infiltration into adipose tissue (AT) as a key contributor to inflammation and…”
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Regulation of tissue iron homeostasis: the macrophage "ferrostat" by Winn, Nathan C, Volk, Katrina M, Hasty, Alyssa H

“…Iron is an essential element for multiple fundamental biological processes required for life; yet iron overload can be cytotoxic. Consequently, iron…”
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Contributions of innate type 2 inflammation to adipose function by Bolus, W. Reid, Hasty, Alyssa H.

“…A critical contributor to the health consequences of the obesity epidemic is dysregulated adipose tissue (AT) homeostasis. While white, brown, and beige AT…”
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The therapeutic potential of TREM2 in cancer by Wolf, Elysa M., Fingleton, Barbara, Hasty, Alyssa H.

“…Cancer continues to be a substantial health concern and a leading cause of death in the United States and around the world. Therefore, it is important to…”
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Stearic Acid Accumulation in Macrophages Induces Toll-Like Receptor 4/2-Independent Inflammation Leading to Endoplasmic Reticulum Stress–Mediated Apoptosis by Anderson, Emily K, Hill, Andrea A, Hasty, Alyssa H

“…OBJECTIVE—Elevated serum free fatty acid levels are associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. Macrophages are…”
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Myeloid-specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice by Winn, Nathan C, Wolf, Elysa M, Cottam, Matthew A, Bhanot, Monica, Hasty, Alyssa H

“…Tissue iron overload is associated with insulin resistance and mitochondrial dysfunction in rodents and humans; however, the mechanisms or cell types that…”
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Editorial: The role of macrophages in metabolic disorders by Jarajapu, Yagna P. R., Hasty, Alyssa H.

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Weight cycling induces innate immune memory in adipose tissue macrophages by Caslin, Heather L, Cottam, Matthew A, Piñon, Jacqueline M, Boney, Likem Y, Hasty, Alyssa H

“…Weight loss improves obesity-associated diabetes risk. However, most individuals regain weight, which worsens the risk of developing diabetes and…”
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Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution by ORR, Jeb S, KENNEDY, Arion, ANDERSON-BAUCUM, Emily K, WEBB, Corey D, FORDAHL, Steve C, ERIKSON, Keith M, YAOFANG ZHANG, ETZERODT, Anders, MOESTRUP, Søren K, HASTY, Alyssa H

“…Adipose tissue (AT) expansion is accompanied by the infiltration and accumulation of AT macrophages (ATMs), as well as a shift in ATM polarization. Several…”
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The role of adipose tissue in mediating the beneficial effects of dietary fish oil by Puglisi, Michael J., Hasty, Alyssa H., Saraswathi, Viswanathan

“…Fish oil improves several features of metabolic syndrome (MetS), such as dyslipidemia, insulin resistance and hepatic steatosis. Fish oil may mediate some of…”
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Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance by Iwasaki, Hitoshi, Ishikawa, Mayumi, Hasty, Alyssa H, Matsui, Toshiyuki, Ishigaki, Naomi, Takahashi, Akimitsu, Inoue, Noriyuki, Okada, Sumiyo, Toyoshima, Hideo, Ohashi, Ken, Osuga, Jun-ichi, Sone, Hirohito, Yatoh, Sigeru, Nakagawa, Yoshimi, Matsuzaka, Takashi, Iwasaki, Yuko, Yamamoto, Takashi, Suzuki, Hiroaki, Kumadaki, Shin, Yahagi, Naoya, Kato, Toyonori, Karasawa, Tadayoshi, Atsumi, Ayaka, Sekiya, Motohiro, Yamada, Nobuhiro, Shimano, Hitoshi

“…Insulin resistance is often associated with obesity and can precipitate type 2 diabetes. To date, most known approaches that improve insulin resistance must be…”
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The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue by Surmi, Bonnie K, Hasty, Alyssa H

“…Abstract The role of the immune system is to recognize pathogens, tumor cells or dead cells and to react with a very specific and localized response. By taking…”
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Knockdown of microglial iron import gene, Slc11a2, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer's disease by Robertson, Katrina Volk, Rodriguez, Alec S, Cartailler, Jean-Philippe, Shrestha, Shristi, Schleh, Michael W, Schroeder, Kyle R, Valenti, Arianna M, Kramer, Alec T, Harrison, Fiona E, Hasty, Alyssa H

“…Microglial cell iron load and inflammatory activation are significant hallmarks of late-stage Alzheimer's disease (AD). In vitro, microglia preferentially…”
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An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload by Ameka, Magdalene K, Beavers, William N, Shaver, Ciara M, Ware, Lorraine B, Kerchberger, Vern Eric, Schoenfelt, Kelly Q, Sun, Lili, Koyama, Tatsuki, Skaar, Eric P, Becker, Lev, Hasty, Alyssa H

“…Adipocyte iron overload is a maladaptation associated with obesity and insulin resistance. The objective of the current study was to determine whether and how…”
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CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue by Bolus, W. Reid, Gutierrez, Dario A., Kennedy, Arion J., Anderson‐Baucum, Emily K., Hasty, Alyssa H.

“…Altered eosinophil content identified in adipose tissue of CCR2‐deficient mice, associated with changes in macrophage polarization and type‐2 cytokine…”
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The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue by Sprenkle, Neil T., Winn, Nathan C., Bunn, Kaitlyn E., Zhao, Yang, Park, Deborah J., Giese, Brenna G., Karijolich, John J., Ansel, K. Mark, Serezani, C. Henrique, Hasty, Alyssa H., Pua, Heather H.

“…Identifying molecular circuits that control adipose tissue macrophage (ATM) function is necessary to understand how ATMs contribute to tissue homeostasis and…”
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Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia by Gutierrez, Dario A., Puglisi, Michael J., Hasty, Alyssa H.

“…Obesity is associated with increased prevalence of metabolic disorders, such as inflammation, insulin resistance, and dyslipidemia, which can predispose an…”
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Mouse models of the metabolic syndrome by Kennedy, Arion J, Ellacott, Kate L J, King, Victoria L, Hasty, Alyssa H

“…The metabolic syndrome (MetS) is characterized by obesity concomitant with other metabolic abnormalities such as hypertriglyceridemia, reduced high-density…”
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