Search Results - "HASKARD, D. O."

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma by Barbarulo, A, Iansante, V, Chaidos, A, Naresh, K, Rahemtulla, A, Franzoso, G, Karadimitris, A, Haskard, D O, Papa, S, Bubici, C

“…Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM). Jun N-terminal kinase (JNK) signaling has been implicated in MM…”
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Mechanisms of inflammation in gout by Dalbeth, N., Haskard, D. O.

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Hemoglobin Scavenger Receptor CD163 Mediates Interleukin-10 Release and Heme Oxygenase-1 Synthesis: Antiinflammatory Monocyte-Macrophage Responses In Vitro, in Resolving Skin Blisters In Vivo, and After Cardiopulmonary Bypass Surgery by Philippidis, P, Mason, J.C, Evans, B.J, Nadra, I, Taylor, K.M, Haskard, D.O, Landis, R.C

“…ABSTRACT—The recently described hemoglobin scavenger receptor CD163 mediates the endocytosis of hemoglobin:haptoglobin (Hb:Hp) complexes and thereby counters…”
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The exaggerated inflammatory response in Behçet's syndrome: identification of dysfunctional post‐transcriptional regulation of the IFN‐γ/CXCL10 IP‐10 pathway by Ambrose, N., Khan, E., Ravindran, R., Lightstone, L., Abraham, S., Botto, M., Johns, M., Haskard, D. O.

“…Summary The mechanisms underlying the exaggerated inflammatory response in Behçet's syndrome (BS) remain poorly understood. We investigated the response of…”
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Accelerated atherosclerosis in inflammatory rheumatic diseases by Haskard, DO

“…Over recent years it has become clear that patients with inflammatory rheumatic diseases are at increased risk of developing atherosclerosis. The exact causes…”
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Wireless capsule endoscopy in the investigation of intestinal Behçet's syndrome by Hamdulay, S. S., Cheent, K., Ghosh, C., Stocks, J., Ghosh, S., Haskard, D. O.

“…Objective. Intestinal Behçet's Syndrome (BS) is a difficult diagnosis to establish. We describe the use of wireless capsule endoscopy (WCE) in the…”
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Both Fcγ and complement receptors mediate transfer of immune complexes from erythrocytes to human macrophages under physiological flow conditions in vitro by Hepburn, A. L., Mason, J. C., Wang, S., Shepherd, C. J., Florey, O., Haskard, D. O., Davies, K. A.

“…Summary Abnormal clearance by the mononuclear phagocytic system of immune complexes (IC) is important in the pathogenesis of systemic lupus erythematosus…”
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Clinical inhibition of the seven-transmembrane thrombin receptor (PAR1) by intravenous aprotinin during cardiothoracic surgery by DAY, J. R. S, PUNJABI, P. P, RANDI, A. M, HASKARD, D. O, LANDIS, R. C, TAYLOR, K. M

“…Protease-activated receptor-1 (PAR1) is the principal thrombin receptor in the vasculature, and antagonists against this receptor are in preclinical trials…”
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Antibody targeted gene transfer to endothelium by Tan, P. H., Manunta, M., Ardjomand, N., Xue, S. A., Larkin, D. F. P., Haskard, D. O., Taylor, K. M., George, A. J. T.

“…Background One of the drawbacks of the currently available vectors for gene therapy is the lack of selectivity in gene delivery. We have therefore investigated…”
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Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation by Thornton, C C, Al-Rashed, F, Calay, D, Birdsey, G M, Bauer, A, Mylroie, H, Morley, B J, Randi, A M, Haskard, D O, Boyle, J J, Mason, J C

“…Premature cardiovascular events complicate chronic inflammatory conditions. Low-dose weekly methotrexate (MTX), the most widely used disease-modifying drug for…”
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Scintigraphy using a technetium 99m‐labelled anti‐E‐selectin Fab fragment in rheumatoid arthritis by Jamar, F., Houssiau, F. A., Devogelaer, J.‐P., Chapman, P. T., Haskard, D. O., Beaujean, V., Beckers, C., Manicourt, D.‐H., Peters, A. M.

“…Objective. We previously described a novel radiolabelled monoclonal antibody (1.2B6), which reacts with porcine E‐selectin, for targeting activated endothelium…”
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Expression of intercellular adhesion molecule-1 in atherosclerotic plaques by Poston, RN, Haskard, DO, Coucher, JR, Gall, NP, Johnson-Tidey, RR

“…Immunohistochemistry of human atherosclerotic arteries demonstrates expression of the intercellular adhesion molecule-1 (ICAM-1) on endothelial cells,…”
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IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-gamma by Thornhill, MH, Haskard, DO

“…Alteration in the surface membrane of endothelial cells (EC) is a feature of endothelial activation both at sites of inflammation in vivo and after stimulation…”
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Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17 by Lightman, S, Taylor, S R J, Bunce, C, Longhurst, H, Lynn, W, Moots, R, Stanford, M, Tomkins-Netzer, O, Yang, D, Calder, V L, Haskard, D O

“…To determine whether the addition of 26 weeks of subcutaneous peginterferon-α-2b could reduce the requirement for systemic corticosteroids and conventional…”
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Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways by MONTEFORT, S, GRATZIOU, C, GOULDING, D, POLOSA, R, HASKARD, D. O, HOWARTH, P. H, HOLGATE, S. T, CARROLL, M. P

“…We have examined the mucosal changes occurring in bronchial biopsies from six atopic asthmatics 5-6 h after local endobronchial allergen challenge and compared…”
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The inflammatory effect of cardiopulmonary bypass on leukocyte extravasation in vivo by Evans, B.J., MRCS, Haskard, D.O., DM, Finch, J.R., MRCS, Hambleton, I.R., PhD, Landis, R.C., PhD, Taylor, K.M., MD

“…Objective Extravascular trafficking of leukocytes into organs is thought to play a major role in the pathophysiologic mechanisms of the inflammatory response…”
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A rapid method for labelling CD4 + T cells with ultrasmall paramagnetic iron oxide nanoparticles for magnetic resonance imaging that preserves proliferative, regulatory and migratory behaviour in vitro by Garden, O.A., Reynolds, P.R., Yates, J., Larkman, D.J., Marelli-Berg, F.M., Haskard, D.O., Edwards, A.D., George, A.J.T.

“…A number of techniques have been developed to track the migration of T cells in vivo, but they all suffer significant shortcomings, including the examination…”
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Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells by Tan, P.H, Chan, C, Xue, S.A, Dong, R, Ananthesayanan, B, Manunta, M, Kerouedan, C, Cheshire, N.J.W, Wolfe, J.H, Haskard, D.O, Taylor, K.M, George, A.J.T

“…The vascular endothelial cell (EC) plays an essential role in the pathogenesis of inflammation, transplant rejection and tumour metastasis. Most research on…”
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Non-invasive imaging in the diagnosis and management of Takayasu’s arteritis by Andrews, J, Al-Nahhas, A, Pennell, D J, Hossain, M S, Davies, K A, Haskard, D O, Mason, J C

“…Objectives: Takayasu’s arteritis (TA) is a rare disease, in which early diagnosis and assessment of treatment efficacy remain a problem. Signs and symptoms may…”
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OP20. IMAGING ENDOTHELIAL ACTIVATION IN INFLAMMATION by Haskard, DO

“…Despite the important role that endothelial activation plays during inflammatory responses, molecular changes in endothelium are relatively inaccessible to…”
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