HE4 Expression Can Be Associated with Lymph Node Metastases and Disease-free Survival in Breast Cancer

This study investigated the potential of HE4 to predict disease-free survival for patients with breast cancer. One hundred and twenty-nine patients with breast cancer underwent surgery from January 2004 to September 2009. Immunohistochemical analysis (IHC) and RT-PCR were used to determine the expre...

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Bibliographic Details
Published in:	Anticancer research Vol. 30; no. 11; pp. 4779 - 4783
Main Authors:	KAMEI, Mirei, YAMASHITA, Shin-Ichi, KAWAHARA, Katsunobu, TOKUISHI, Keita, HASHIOTO, Takafumi, MOROGA, Toshihiko, SUEHIRO, Shuji, ONO, Kiyoshi, MIYAWAKI, Michiyo, TAKENO, Shinsuke, YAMAMOTO, Satoshi
Format:	Journal Article
Language:	English
Published:	Attiki International Institute of Anticancer Research 01-11-2010
Subjects:	beta-Defensins Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - secondary Disease-Free Survival Epididymal Secretory Proteins - genetics Epididymal Secretory Proteins - metabolism Female Hematologic and hematopoietic diseases Humans Immunoenzyme Techniques Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Lymphatic Metastasis Medical sciences Microscopy, Fluorescence Middle Aged Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Prognosis Reverse Transcriptase Polymerase Chain Reaction RNA, Neoplasm - genetics Survival Rate Tumor Cells, Cultured Tumors Breast disease Prognosis prognostic factor Malignant lymphadenopathy Malignant hemopathy Breast cancer Malignant tumor WFDC2 Lymph node metastasis Mammary gland diseases Cancerology metastasis HE4 Disease free survival Cancer
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Summary:	This study investigated the potential of HE4 to predict disease-free survival for patients with breast cancer. One hundred and twenty-nine patients with breast cancer underwent surgery from January 2004 to September 2009. Immunohistochemical analysis (IHC) and RT-PCR were used to determine the expression of HE4 which was compared with the clinicopathological factors or prognosis. A total of 71 of 129 cases (55%) were HE4 positive and two cell lines expressed HE4 protein and mRNA. No correlation was found between HE4 expression by IHC and clinicopathological factors; however, lymph node involvement was closely associated with HE4 expression. Five-year disease-free survival in the HE4-positive group (58.6%) was significantly worse than that in the negative group (85.6%, p=0.04). These data showed that HE4 expression is associated with lymph node involvement and is a possible predictive factor of breast cancer recurrence.
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ISSN:	0250-7005 1791-7530