Search Results - "HASHIM, G. A"

T Cell Receptor Peptide Therapy Triggers Autoregulation of Experimental Encephalomyelitis by Offner, Halina, Hashim, George A., Vandenbark, Arthur A.

“…Encephalitogenic T cells specific for myelin basic protein share common V$_\beta$8 peptide sequences in their T cell receptor (TCR) that can induce…”
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Two Separate 18-Amino Acid Domains of Tau Promote the Polymerization of Tubulin by Ennulat, D J, Liem, R K, Hashim, G A, Shelanski, M L

“…Tau is a heat-stable microtubule-associated protein which promotes tubulin polymerization. The assembly promoting region of tau was localized using synthetic…”
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T cell receptor peptides in treatment of autoimmune disease: Rationale and potential by Vandenbark, A.A., Hashim, G.A., Offner, H.

“…The natural tendency in T cell‐mediated autoimmune conditions to develop focused antigen‐specific responses that over‐utilize certain T cell receptor (TCR) V…”
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Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis by Chou, Y K, Bourdette, D N, Offner, H, Whitham, R, Wang, R Y, Hashim, G A, Vandenbark, A A

“…T cell sensitization to two myelin components, myelin basic protein (MBP) and myelin proteolipid protein (PLP), may be important to the pathogenesis of…”
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Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia by Kilidireas, K, Latov, N, Strauss, D H, Gorig, A D, Hashim, G A, Gorman, J M, Sadiq, S A

“…Immune mechanisms are thought to be important in a subpopulation of patients with schizophrenia. We examined the specificity of neural antibodies in patients…”
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T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats by OFFNER, H, HASHIM, G. A, CELNIK, B, GALANG, A, XIAOBIN LI, BURNS, F. R, NING SHEN, HEBER-KATZ, E, VANDENBARK, A. A

“…The major encephalitogenic epitope for Lewis rats is the 72-89 sequence of guinea pig basic protein (GP-BP) or rat basic protein (Rt-BP). T cells responsive to…”
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Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. II. Biased T cell receptor V beta expression predominates in spinal cord infiltrating T cells by Gold, DP, Vainiene, M, Celnik, B, Wiley, S, Gibbs, C, Hashim, GA, Vandenbark, AA, Offner, H

“…The immune response of Lewis rat lymph node T cells to guinea pig myelin basic protein (GP-BP) in experimental allergic encephalomyelitis is directed primarily…”
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Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis by WHITHAM, R. H, BOURDETTE, D. N, HASHIM, G. A, HERNDON, R. M, ILG, R. C, VANDENBARK, A. A, OFFNER, H

“…Relapsing experimental autoimmune encephalomyelitis (R-EAE) can be induced in SJL/J mice by immunization with spinal cord homogenate and adjuvant. The specific…”
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Proteolipid protein interactions in transfectants: implications for myelin assembly by Sinoway, M P, Kitagawa, K, Timsit, S, Hashim, G A, Colman, D R

“…The proteolipid proteins (PLP and DM20) are major constituents of CNS myelin, but how they are delivered to and organized within the oligodendrocyte plasma…”
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Myelin basic protein: structure, function and antigenic determinants by Hashim, G A

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Delineation and synthesis of the membrane receptor-binding domain of sex hormone-binding globulin by Khan, M S, Hryb, D J, Hashim, G A, Romas, N A, Rosner, W

“…Sex hormone-binding globulin (SHBG) is a plasma glycoprotein which binds certain steroids. It, in turn, binds to a specific receptor on cell membranes. This…”
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Antibodies specific for VB8 receptor peptide suppress experimental autoimmune encephalomyelitis by Hashim, GA, Vandenbark, AA, Galang, AB, Diamanduros, T, Carvalho, E, Srinivasan, J, Jones, R, Vainiene, M, Morrison, WJ, Offner, H

“…Recent studies from our laboratory have shown, for the first time, that a synthetic peptide from that TCR VB chain used preferentially by encephalitogenic T…”
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Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice by Whitham, RH, Jones, RE, Hashim, GA, Hoy, CM, Wang, RY, Vandenbark, AA, Offner, H

“…Synthetic peptides of proteolipid protein (PLP) were screened for their ability to induce experimental autoimmune encephalomyelitis (EAE) in SJL/J, PL/J, and…”
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Receptors for nerve growth factor on rat spleen mononuclear cells by Thorpe, L W, Stach, R W, Hashim, G A, Marchetti, D, Perez-Polo, J R

“…Considerable evidence is mounting to support the concept of a modulatory role for the brain and neuroendocrine system on the immune response. This…”
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Treatment of relapsing experimental autoimmune encephalomyelitis with T cell receptor peptides by Whitham, R H, Kotzin, B L, Buenafe, A C, Weinberg, A D, Jones, R E, Hashim, G A, Hoy, C M, Vandenbark, A A, Offner, H

“…Restricted T cell receptor (TCR) VB gene usage by T cells for recognition of antigens involved in the production of experimental autoimmune encephalomyelitis…”
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Myelin basic protein specific T cell lines and clones derived from the CNS of rats with EAE only recognize encephalitogenic epitopes by Bourdette, D N, Vainiene, M, Morrison, W, Jones, R, Turner, M J, Hashim, G A, Vandenbark, A A, Offner, H

“…The epitope specificities of myelin basic protein (BP) specific T cell lines derived from the spinal cords (SC) and lymph nodes (LN) of rats with experimental…”
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Human T-cell response to myelin basic protein in multiple sclerosis patients and healthy subjects by Tournier-Lasserve, E, Hashim, G A, Bach, M A

“…In order to explore the T-cell repertoire to myelin basic protein (BP) of both multiple sclerosis (MS) patients and healthy subjects (HS), we raised BP…”
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Episodic changes in T-cell frequencies to myelin basic protein in patients with multiple sclerosis by VANDENBARK, A. A, BOURDETTE, D. N, WHITHAM, R, CHOU, Y. K, HASHIM, G. A, OFFNER, H

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T cell receptor V beta gene usage in the recognition of myelin basic protein by cerebrospinal fluid- and blood-derived T cells from patients with multiple sclerosis by Chou, Y K, Buenafe, A C, Dedrick, R, Morrison, W J, Bourdette, D N, Whitham, R, Atherton, J, Lane, J, Spoor, E, Hashim, G A

“…Because of its proximity to the central nervous system, the cerebrospinal fluid (CSF) represents an important source of T cells that potentially could mediate…”
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Biological activity of region 65-102 of the myelin basic protein by Hashim, G A, Day, E D, Fredane, L, Intintola, P, Carvalho, E

“…Region 65-102 of the myelin basic protein (MBP) houses a number of antigenic determinants known to induce delayed-type hypersensitivity, experimental allergic…”
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