Search Results - "HASHIM, Audrey"

Cocaine perturbs mitovesicle biology in the brain by D'Acunzo, Pasquale, Ungania, Jonathan M., Kim, Yohan, Barreto, Bryana R., DeRosa, Steven, Pawlik, Monika, Canals‐Baker, Stefanie, Erdjument‐Bromage, Hediye, Hashim, Audrey, Goulbourne, Chris N., Neubert, Thomas A., Saito, Mariko, Sershen, Henry, Levy, Efrat

“…Cocaine, an addictive psychostimulant, has a broad mechanism of action, including the induction of a wide range of alterations in brain metabolism and…”
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Differential regulation of catechol-O-methyltransferase expression in a mouse model of aggression by Ginsberg, Stephen D., Che, Shaoli, Hashim, Audrey, Zavadil, Jiri, Cancro, Robert, Lee, Sang H., Petkova, Eva, Sershen, Henry W., Volavka, Jan

“…This study was designed to understand molecular and cellular mechanisms underlying aggressive behaviors in mice exposed to repeated interactions in their…”
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Serotonin-mediated striatal dopamine release involves the dopamine uptake site and the serotonin receptor by Sershen, Henry, Hashim, Audrey, Lajtha, Abel

“…Modulation of striatal dopamine (DA) release by serotonin (5HT) and its antagonists was studied utilizing in vitro perfusion techniques. In isolated striatal…”
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Cocaine Modulates the Neuronal Endosomal System and Extracellular Vesicles in a Sex-Dependent Manner by Barreto, Bryana R., D’Acunzo, Pasquale, Ungania, Jonathan M., Das, Sasmita, Hashim, Audrey, Goulbourne, Chris N., Canals-Baker, Stefanie, Saito, Mitsuo, Saito, Mariko, Sershen, Henry, Levy, Efrat

“…In multiple neurodevelopmental and neurodegenerative disorders, endosomal changes correlate with changes in exosomes. We examined this linkage in the brain of…”
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Phencyclidine-induced dysregulation of dopamine response to amphetamine in prefrontal cortex and striatum by BALLA, Andrea, HASHIM, Audrey, BURCH, Sarah, JAVITT, Daniel C, LAJTHA, Abel, SERSHEN, Henry

“…Phencyclidine (PCP) administration in rodents has been used to model aspects of schizophrenia. One aspect of such treatment has been the enhancement of…”
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Cocaine Induces Sex-Associated Changes in Lipid Profiles of Brain Extracellular Vesicles by Landfield, Qwynn, Saito, Mitsuo, Hashim, Audrey, Canals-Baker, Stefanie, Sershen, Henry, Levy, Efrat, Saito, Mariko

“…Cocaine is a highly addictive stimulant with diverse effects on physiology. Recent studies indicate the involvement of extracellular vesicles (EVs) secreted by…”
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Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice by Rao, Mala V, McBrayer, Mary Kate, Campbell, Jabbar, Kumar, Asok, Hashim, Audrey, Sershen, Henry, Stavrides, Philip H, Ohno, Masuo, Hutton, Michael, Nixon, Ralph A

“…Tau pathogenicity in Alzheimer's disease and other tauopathies is thought to involve the generation of hyperphosphorylated, truncated, and oligomeric tau…”
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Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo by Yuan, A, Sershen, H, Veeranna, Basavarajappa, B S, Kumar, A, Hashim, A, Berg, M, Lee, J-H, Sato, Y, Rao, M V, Mohan, P S, Dyakin, V, Julien, J-P, Lee, V M-Y, Nixon, R A

“…Synaptic roles for neurofilament (NF) proteins have rarely been considered. Here, we establish all four NF subunits as integral resident proteins of synapses…”
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Modulating NMDA Receptor Function with d-Amino Acid Oxidase Inhibitors: Understanding Functional Activity in PCP-Treated Mouse Model by Sershen, Henry, Hashim, Audrey, Dunlop, David S., Suckow, Raymond F., Cooper, Tom B., Javitt, Daniel C.

“…Deficits in N -methyl- d -aspartate receptor (NMDAR) function are increasingly linked to persistent negative symptoms and cognitive deficits in schizophrenia…”
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Reversal of Phencyclidine-Induced Hyperactivity by Glycine and the Glycine Uptake Inhibitor Glycyldodecylamide by Javitt, M.D., Ph.D, Daniel C, Sershen, Ph.D, Henry, Hashim, M.S, Audrey, Lajtha, Ph.D, Abel

“…Phencyclidine (PCP) induces a psychotic state that closely resembles schizophrenia. In preclinical studies, PCP has been shown to induce its unique behavioral…”
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Effect of ibogaine on cocaine-induced efflux of [ 3H]dopamine and [ 3H]serotonin from mouse striatum by Henry, Sershen, Audrey, Hashim, Abel, Lajtha

“…Ibogaine, an indole alkaloid with proposed antiaddictive properties, has structural similarity to serotonin and has been shown to have affinity to the k-opioid…”
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Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors by Yuan, Aidong, Veeranna, Sershen, Henry, Basavarajappa, Balapal S., Smiley, John F., Hashim, Audrey, Bleiwas, Cynthia, Berg, Martin, Guifoyle, David N., Subbanna, Shivakumar, Darji, Sandipkumar, Kumar, Asok, Rao, Mala V., Wilson, Donald A., Julien, Jean-Pierre, Javitt, Daniel C., Nixon, Ralph A.

“…Neurofilament (NFL) proteins have recently been found to play unique roles in synapses. NFL is known to interact with the GluN1 subunit of N -methyl- d…”
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Novel C-1 substituted cocaine analogs unlike cocaine or benztropine by Reith, Maarten E A, Ali, Solav, Hashim, Audrey, Sheikh, Imran S, Theddu, Naresh, Gaddiraju, Narendra V, Mehrotra, Suneet, Schmitt, Kyle C, Murray, Thomas F, Sershen, Henry, Unterwald, Ellen M, Davis, Franklin A

“…Despite a wealth of information on cocaine-like compounds, there is no information on cocaine analogs with substitutions at C-1. Here, we report on…”
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Increased Dopaminergic Neuron Sensitivity to 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in Transgenic Mice Expressing Mutant A53T α-Synuclein by Yu, Wai Haung, Matsuoka, Yasuji, Sziráki, István, Hashim, Audrey, LaFrancois, John, Sershen, Henry, Duff, Karen E.

“…Familial Parkinson’s disease (PD) has been linked to point mutations and duplication of the α-synuclein gene and mutant α-synuclein expression increases the…”
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Modulation of Striatal Dopamine Release by Glycine Transport Inhibitors by JAVITT, Daniel C, HASHIM, Audrey, SERSHEN, Henry

“…Traditional models of schizophrenia have focused primarily upon dopaminergic (DA) dysregulation. In contrast, more recent models focus on dysfunction of…”
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Receptors in the ventral tegmental area mediating nicotine-induced dopamine release in the nucleus accumbens by SZIRAKI, Istvan, SERSHEN, Henry, HASHIM, Audrey, LAJTHA, Abel

“…Nicotine or cocaine, when administered intravenously, induces an increase of extracellular dopamine in the nucleus accumbens. The nicotine-mediated increase…”
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Increased Dopaminergic Neuron Sensitivity to 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in Transgenic Mice Expressing Mutant A53T [alpha]-Synuclein by Yu, Wai Haung, Matsuoka, Yasuji, Sziráki, István, Hashim, Audrey, LaFrancois, John, Sershen, Henry, Duff, Karen E

“…Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein gene and mutant α-synuclein expression increases the…”
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Gender differences in kappa-opioid modulation of cocaine-induced behavior and NMDA-evoked dopamine release by Sershen, Henry, Hashim, Audrey, Lajtha, Abel

“…It has been reported that kappa-opioids produce greater analgesia in women than in men. Sex differences are also apparent in drug-induced behaviors. Repeated…”
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Receptor systems participating in nicotine-specific effects by Sziráki, István, Sershen, Henry, Benuck, Myron, Hashim, Audrey, Lajtha, Abel

“…It is generally accepted that self-administration of drugs is prompted primarily by a reward system driven by an increase in extracellular dopamine in the…”
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Inhibition of striatal dopamine release by glycine and glycyldodecylamide by Javitt, Daniel C, Sershen, Henry, Hashim, Audrey, Lajtha, Abel

“…Phencyclidine (PCP) and other N-methyl-D-aspartate (NMDA) antagonists induce schizophrenia-like symptoms in humans. In rodents, PCP induces a syndrome of…”
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