Search Results - "HASHIGAKI, Kuniko"

Synthesis and Antitumor Activity of Fused Quinoline Derivatives. IV. Novel 11-Aminoindolo[3, 2-b]quinolines by TAKEUCHI, Yasuo, ODA, Toshiaki, CHANG, Ming-rong, OKAMOTO, Yoko, ONO, Junko, ODA, Yoko, HARADA, Kyoko, HASHIGAKI, Kuniko, YAMATO, Masatoshi

“…Indolo[3, 2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were…”
Get full text

Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains by Yamato, Masatoshi, Ando, Junko, Sakaki, Katsuhito, Hashigaki, Kuniko, Wataya, Yusuke, Tsukagoshi, Shigeru, Tashiro, Tazuko, Tsuruo, Takashi

“…Bistropolone derivatives (4-12) containing differing lengths of linkage between the two tropolone rings were prepared and examined for their antitumor activity…”
Get full text

Synthesis and antitumor activity of tropolone derivatives. 6. Structure-activity relationships of antitumor-active tropolone and 8-hydroxyquinoline derivatives by Yamato, Masatoshi, Hashigaki, Kuniko, Yasumoto, Yoshiko, Sakai, Junko, Luduena, Richard F, Banerjee, Asok, Tsukagoshi, Shigeru, Tashiro, Tazuko, Tsuruo, Takashi

“…The bis derivative 6 of 8-hydroxyquinoline, which, like tropolones, readily forms a chelate, was synthesized and found to have high potency (dose = 12.5 mg/kg,…”
Get full text

Synthesis and Antitumor Activity of Fused Quinoline Derivatives. II. Novel 4- and 7-Hydroxyindolo-[3, 2-b]quinolines by YAMATO, Masatoshi, TAKEUCHI, Yasuo, CHANG, Ming-rong, HASHIGAKI, Kuniko

“…Novel indolo[3, 2-b]quinoline derivatives (1c-f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound 1a, were prepared and…”
Get full text

Synthesis and antitumor activity of tropolone derivatives. 4 by Yamato, Masatoshi, Hashigaki, Kuniko, Sakai, Junko, Kawasaki, Youko, Tsukagoshi, Shigeru, Tashiro, Tazuko

“…Modifications of monotropolone 2 having poor potency against P388 in mice were studied. The alpha-ethoxy group of 2, prepared from hinokitiol and benzaldehyde…”
Get full text

Alkoxycarbonylmethylation of(3R, 10bS)-3-Phenyl-2, 3, 5, 6-tetrahydro-10bH-oxazolo[2, 3-a]isoquinoline by TAKEUCHI, Yasuo, KAMADA, Yoshio, NISHIMURA, Koji, NISHIOKA, Hiromi, NISHIKAWA, Masayo, HASHIGAKI, Kuniko, YAMATO, Masatoshi, HARAYAMA, Takashi

“…As part of a series of studies on synthesis of chiral 1-alkyltetrahydroisoquinolines, asymmetric synthesis of 1-alkoxycarbonylmethyl-1, 2, 3,…”
Get full text

Synthesis and antitumor activity of tropolone derivatives. 1 by Yamato, Masatoshi, Hashigaki, Kuniko, Kokubu, Nobuhiko, Tsuruo, Takashi, Tashiro, Tazuko

Get full text

Synthesis and Antitumor Activity of Fused Quinoline Derivatives by YANATO, Masatoshi, TAKEUCHI, Yasuo, CHANG, Ming-rong, HASHIGAKI, Kuniko, TSURUO, Takashi, TASHIRO, Tazuko, TSUKAGOSHI, Shigeru

“…Some tetracyclic quinolines (9 and 14) with a [2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino side chain were prepared and their deoxyribonucleic acid (DNA)…”
Get full text

Synthesis and antitumor activity of tropolone derivatives. 3 by Yamato, Masatoshi, Hashigaki, Kuniko, Kokubu, Nobuhiko, Tashiro, Tazuko, Tsuruo, Takashi

“…As part of a study on the antitumor activities of tropolone derivatives prepared from hinokitiol, which naturally occurs in the plants of Chamaecyparis…”
Get full text

SYNTHESIS AND ANTITUMOR ACTIVITY OF 7-(N-GLYCOSYLAMINO)-INDOLO[3, 2-b]QUINOLINES by TAKEUCHI, Yasuo, CHANG, Ming-rong, HASHIGAKI, Kuniko, YAMATO, Masatoshi

“…Novel indolo[3, 2-b]quinolines (1d-g), introduced at the 7-position with an N-glycosylamino group, were prepared and thier antitumor activities against…”
Get full text

Intramolecular Michael Reaction in Diastereoselective Synthesis of dl-Griseofulvin by TAKEUCHI, Yasuo, WATANABE, Ikuo, TOMOZANE, Hideo, HASHIGAKI, Kuniko, YAMATO, Masatoshi

“…The diastereoselective cyclization of 2a to 5a, which was employed in our novel synthesis of dl-griseofulvin (7a), was studied in detail. It was found that the…”
Get full text

Synthesis and antitumor activity of tropolone derivatives. 2 by Yamato, Masatoshi, Hashigaki, Kuniko, Ishikawa, Shigetaka, Kokubu, Nobuhiko, Inoue, Yuka, Tsuruo, Takashi, Tashiro, Tazuko

“…Structural requirement for antitumor activity of tropolone derivatives 2-4 was explored. Isochroman derivatives (6-17, 20, and 23) and alpha,…”
Get full text

Synthesis and Antitumor Activity of Fused Quinoline Derivatives. III. Novel N-Glycosylaminoindolo(3,2-b)quinolines by TAKEUCHI, Yasuo, CHANG, Ming-rong, HASHIGAKI, Kuniko, TASHIRO, Tazuko, TSURUO, Takashi, TSUKAGOSHI, Shigeru, YAMATO, Masatoshi

Get full text

Synthesis and antitumor activity of tropolone derivatives. 5 by Yamato, Masatoshi, Hashigaki, Kuniko, Sakai, Junko, Takeuchi, Yasuo, Tsukagoshi, Shigeru, Tashiro, Tazuko, Tsuruo, Takashi

“…As part of a study on the structure-activity relationship of antitumor-active tropolone derivatives, a series of bistropone analogues, related to potently…”
Get full text

Synthesis and Antiulcer Activity of (Isochroman-1-yl)alkylamines. II by YAMATO, MASATOSHI, HASHIGAKI, KUNIKO, HITOMI, SUSUMU, ISHIKAWA, SHIGETAKA

“…Numerous analogues of N-phenethyl-2-(isochroman-1-yl)-1-methylethylamine (3b), previously found to have inhibitory activity against aspirin-induced ulcer and…”
Get full text

A New Method for the Preparation of 2-(Alkylamino) benzoxazoles and 2-(Alkylimino) benzoxazolines by YAMATO, MASATOSHI, TAKEUCHI, YASUO, HATTORI, KYOKO, HASHIGAKI, KUNIKO

“…New syntheses of 2-(alkylamino) benzoxazoles (III) and 3-alkyl-2-(alkylimino) benzoxazolines (IV) were developed. Various compounds III were obtained by the…”
Get full text

Synthesis and Antiulcer Activity of (Isochroman-1-yl)alkylamines. I by YAMATO, MASATOSHI, HASHIGAKI, KUNIKO, ISHIKAWA, SHIGETAKA, HITOMI, SUSUMU, KOKEGUCHI, TERUMI

“…N-benzyl-2-(isochroman-1-yl)-1-methylethylamine (6f), prepared by the reaction of 1-ethoxy-isochroman (4) and acetone followed by reductive amination, was…”
Get full text

Synthesis of dl-agrimonolide (Constituent of rhizome of Agrimonia pilosa Ledeb) by Yamato, M, Hashigaki, K

“…The structure of agrimonolide, isolated as a constituent of Agrimonia pilosa LEDEB. in 1958, was confirmed by the synthesis to be 6,…”
Get full text

THE SYNTHESIS AND ANTITUMOR ACTIVITIES OF TROPOLONE AND 8-HYDROXYQUINOLINE DERIVATIVES by Yamato, Masatoshi, Hashigaki, Kuniko, Yasumoto, Yoshiko, Sakai, Junko, Tsukagoshi, Shigeru, Tashiro, Tazuko, Tsuruo, Takashi

“…The bis-derivatives (4-6) of 8-hydroxyquinoline, which, like tropolones, readily form a chelate, were synthesized and found to be actively antitumorous in…”
Get full text

ANTITUMOR ACTIVITY OF ISOCHROMANYLTROPOLONES by Yamato, Masatoshi, Ishikawa, Tadataka, Ishikawa, Shigetaka, Hashigaki, Kuniko

“…The reaction of 1-ethoxyisochroman (1) with 4-isopropyltropolone (2) (hinokitiol, β-thujaplicin) afforded 3-(1-isochromanyl)-6-isopropyltropo-lone (3)…”
Get full text