Search Results - "HASHASH, Ahmad"

Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase by FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward

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Tu2031 - Targeted Delivery of Linaclotide to Specific Areas of The Intestine Affects Clinical Efficacy in Patients with Irritable Bowel Syndrome with Constipation (IBS-C) by Chey, William D., Chamberlin, Paul, Bochenek, Wieslaw, Tripp, Kenneth, Higgins, Carolyn S., Omniewski, Nicholas, Fox, Susan M., Hall, Michael, Hashash, Ahmad, Miller, Matthew, O'Dea, Christopher R., Currie, Mark

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Targeted Delivery of Linaclotide to Specific Areas of The Intestine Affects Clinical Efficacy in Patients with Irritable Bowel Syndrome with Constipation (IBS-C) by Chey, William D, Chamberlin, Paul, Bochenek, Wieslaw, Tripp, Kenneth, Higgins, Carolyn S, Omniewski, Nicholas, Fox, Susan M, Hall, Michael, Hashash, Ahmad, Miller, Matthew, O'Dea, Christopher R, Currie, Mark

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Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection by Lazerwith, Scott E., Lew, Willard, Zhang, Jennifer, Morganelli, Philip, Liu, Qi, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Byun, Daniel, Mertzman, Michael, Ye, Hong, Chong, Lee, Xu, Lianhong, Appleby, Todd, Chen, Xiaowu, Fenaux, Martijn, Hashash, Ahmad, Leavitt, Stephanie A., Mabery, Eric, Matles, Mike, Mwangi, Judy W., Tian, Yang, Lee, Yu-Jen, Zhang, Jingyu, Zhu, Christine, Murray, Bernard P., Watkins, William J.

“…Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure–activity…”
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Anti‐HCV therapies in chimeric scid‐Alb/uPA mice parallel outcomes in human clinical application by Kneteman, Norman M., Weiner, Amy J., O'Connell, John, Collett, Marc, Gao, Tiejun, Aukerman, Lea, Kovelsky, Rosemary, Ni, Zhi‐Jie, Hashash, Ahmad, Kline, Janine, Hsi, Belinda, Schiller, Daniel, Douglas, Donna, Tyrrell, D Lorne J, Mercer, David F.

“…Compounds with in vitro anti‐hepatitis C virus (HCV) activity are often advanced directly into clinical trials with limited or no in vivo efficacy data. This…”
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SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo by Arbitrario, Jennifer P, Belmont, Brian J, Evanchik, Marc J, Flanagan, W. Michael, Fucini, Raymond V, Hansen, Stig K, Harris, Shannon O, Hashash, Ahmad, Hoch, Ute, Hogan, Jennifer N, Howlett, Anthony R, Jacobs, Jeffrey W, Lam, Joni W, Ritchie, Sean C, Romanowski, Michael J, Silverman, Jeffrey A, Stockett, David E, Teague, Juli N, Zimmerman, Kristin M, Taverna, Pietro

“…Purpose The Aurora family of serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C) plays a key role in cells orderly progression through mitosis…”
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Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors by Ramurthy, Savithri, Aikawa, Mina, Amiri, Payman, Costales, Abran, Hashash, Ahmad, Jansen, Johanna M., Lin, Song, Ma, Sylvia, Renhowe, Paul A., Shafer, Cynthia M., Subramanian, Sharadha, Sung, Leonard, Verhagen, Joelle

“…Two scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro…”
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Water-soluble prodrugs of an Aurora kinase inhibitor by Oslob, Johan D., Heumann, Stacey A., Yu, Chul H., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Delarosa, Erlie, Fung, Amy D., Hashash, Ahmad, Hau, Jonathan, Ivy, Sheryl, Jacobs, Jeffrey W., Lew, Willard, Maung, Jack, McDowell, Robert S., Ritchie, Sean, Romanowski, Michael J., Silverman, Jeffrey A., Yang, Wenjin, Zhong, Min, Fuchs-Knotts, Tarra

“…In vitro and in vivo properties of prodrug derivatives of the Aurora kinase inhibitor SNS-314 are described. Compound 1 (SNS-314) is a potent and selective…”
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Effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult rats by Gibbs, Robert G., Hashash, Ahmad, Johnson, David A.

“…In vivo microdialysis techniques were used to examine the effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying…”
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Solubility, ionization, and partitioning behavior of unsymmetrical disulfide compounds: alkyl 2-imidazolyl disulfides by Hashash, Ahmad, Kirkpatrick, D Lynn, Lazo, John S, Block, Lawrence H

“…Alkyl 2-imidazolyl disulfide compounds are novel antitumor agents, one of which is currently being evaluated in Phase I clinical trials. These molecules…”
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Normal-phase and stability-indicating reversed-phase high-performance liquid chromatographic methods for the determination of the novel antitumor agent: 1-methylpropyl-2-imidazolyldisulfide by Hashash, Ahmad, Lynn Kirkpatrick, D, Egorin, Merrill J, Block, Lawrence H, Lazo, John S

“…1-Methylpropyl-2-imidazolyl disulfide (MID) is a novel antitumor agent currently in Phase I clinical trials. The chromatographic behavior of MID and its…”
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Effect of chronic estrogen treatment on basal and potassium-evoked release of acetylcholine in rat hippocampus as assessed by the {\it in vivo\/} microdialysis technique by Hashash, Ahmad

“…In vivo microdialysis techniques were used to examine the effects of estrogen on potassium-evoked acetylcholine release in the hippocampus and overlying cortex…”
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