Search Results - "HASEGAWA, Tohru"
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Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis
Published in Scientific reports (02-08-2021)“…Multiple factors regulate glucagon-like peptide-1 (GLP-1) secretion, but a group of apparently healthy subjects showed blunted responses of GLP-1 secretion in…”
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Targeting therapy for homocysteic acid in the blood represents a potential recovery treatment for cognition in Alzheimer's disease patients
Published in Aging (Albany, NY.) (14-09-2016)“…At present, we have no reliable means of recovering cognitive impairment in Alzheimer's disease (AD) patients. We hypothesized that homocysteic acid (HA) in…”
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Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice
Published in PloS one (20-01-2010)“…Alzheimer's disease (AD) is an age-associated progressive neurodegenerative disorder with dementia, the exact pathogenic mechanisms of which remain unknown. We…”
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Does a Reduction in the Glomerular Filtration Rate Increase the Overall Severity of Coronary Artery Stenosis?
Published in Internal Medicine (01-01-2016)“…Objective Chronic kidney disease is a risk factor of coronary events, however, its impact on coronary artery stenosis has not yet been clarified with the use…”
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Homocysteic acid induces intraneuronal accumulation of neurotoxic Aβ42: Implications for the pathogenesis of Alzheimer's disease
Published in Journal of neuroscience research (15-06-2005)“…The causes of neuronal dysfunction and degeneration in Alzheimer's disease (AD) are not fully understood, but increased production of neurotoxic forms of…”
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Cardioprotective mechanism of ischemic preconditioning is impaired by postinfarct ventricular remodeling through angiotensin II type 1 receptor activation
Published in Circulation (New York, N.Y.) (25-07-2000)“…Activation of protein kinase C-linked receptors and subsequent opening of the mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channel are crucial in…”
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Roles of Tyrosine Kinase and Protein Kinase C in Infarct Size Limitation by Repetitive Ischemic Preconditioning in the Rat
Published in Journal of cardiovascular pharmacology (01-03-2000)“…In this study, we examined the possibility that infarct-size limitation by repetitive preconditioning (PC) is achieved by activation of both protein kinase C…”
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Prognostic value of the Tei index combining systolic and diastolic myocardial performance in patients with acute myocardial infarction treated by successful primary angioplasty
Published in Heart and vessels (01-03-2004)“…Cardiac systolic (left ventricular ejection fraction) and diastolic (mitral inflow velocity pattern and/or mitral deceleration time) function were reported as…”
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THE DISSOCIATION BETWEEN THE COGNITIVE RESERVE ABILITY AND ALZHEIMER'S PATHOLOGY
Published in Alzheimer's & dementia (01-07-2017)Get full text
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Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator
Published in Oncogene (06-02-1997)“…Ral, a member of small GTP-binding protein (G protein) superfamily, has been suggested to act downstream of Ras, since Ral GDP dissociation stimulator (RalGDS)…”
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Blockade of Angiotensin II Type 1 Receptors Suppressed Free Radical Production and Preserved Coronary Endothelial Function in the Rabbit Heart After Myocardial Infarction
Published in Journal of cardiovascular pharmacology (01-01-2002)“…The hypothesis that blockade of angiotensin II type 1 (AT 1 ) receptors after myocardial infarction prevents coronary endothelial vasomotor dysfunction by…”
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Homocysteic acid in blood can detect mild cognitive impairment (MCI) and MCI due to Alzheimer disease (AD) pathological change
Published in Alzheimer's & dementia (01-12-2020)“…Background Recent our findings present a new early diagnostic marker for mild cognitive impairment (MCI), a pre‐stage of Alzheimer’s disease (AD). It may be a…”
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Clinical and Angiographic Results After MULTI-LINK Stent Implantation and Their Relation to Aggregation of Risk Factors: Two-Year Follow-up
Published in Circulation Journal (01-10-2002)“…Results of trials using the ACS MULTI-LINK (ML) stent, one of the new generation stents, were similar to or slightly better than those of trials using the…”
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Prolonged stress will induce Alzheimer’s disease in elderly people by increased release of homocysteic acid
Published in Medical hypotheses (2007)“…Summary Recently, many papers have reported the physiological functions of amyloid beta and amyloid precursor protein (APP). In particular, one of its…”
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Synthesis of MoSi2-TiSi2 pseudobinary alloys by reactive sintering
Published in Metallurgical and materials transactions. A, Physical metallurgy and materials science (01-03-2000)“…MoSi2-TiSi2 pseudobinary alloys are synthesized from mixtures of elemental powders of molybdenum, silicon, and titanium by reactive sintering under a…”
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O4-04-05: Accelaration of familial Alzheimer's disease by homocysteic acid and recovery from neuropathology by anti-homocysteic acid antibody
Published in Alzheimer's & dementia (01-07-2008)Get full text
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P1‐386: COGNITIVE RECOVERY BY HBF BRAIN FOOD
Published in Alzheimer's & dementia (01-07-2014)Get full text
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