Search Results - "HARWOOD, Steven M"

Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin d deficiency: an exploratory, double blind, randomised controlled trial by Dreyer, Gavin, Tucker, Arthur T, Harwood, Steven M, Pearse, Rupert M, Raftery, Martin J, Yaqoob, Muhammad M

“…Vitamin D deficiency and endothelial dysfunction are non-traditional risk factors for cardiovascular events in chronic kidney disease. Previous studies in…”
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Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger by Andrikopoulos, Petros, Kieswich, Julius, Harwood, Steven M., Baba, Akemichi, Matsuda, Toshio, Barbeau, Olivier, Jones, Keith, Eccles, Suzanne A., Yaqoob, Muhammad M.

“…Thrombin acts on the endothelium by activating protease-activated receptors (PARs). The endothelial thrombin-PAR system becomes deregulated during pathological…”
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Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications by Allen, David A., Yaqoob, Muhammad M., Harwood, Steven M.

“…Cellular responses to high glucose are numerous and varied but ultimately result in functional changes and, often, cell death. High glucose induces oxidative…”
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Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia by Chapagain, Ananda, Caton, Paul W., Kieswich, Julius, Andrikopoulos, Petros, Nayuni, Nanda, Long, Jamie H., Harwood, Steven M., Webster, Scott P., Raftery, Martin J., Thiemermann, Christoph, Walker, Brian R., Seckl, Jonathan R., Corder, Roger, Yaqoob, Muhammad Magdi

“…Insulin resistance and associated metabolic sequelae are common in chronic kidney disease (CKD) and are positively and independently associated with increased…”
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Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis by Harwood, Steven M, Yaqoob, Muhammad M, Allen, David A

“…Calpain and caspase are families of cysteine proteases that have important roles in the initiation, regulation and execution of cell death. The function of…”
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Inosine Monophosphate Dehydrogenase Polymorphisms and Renal Allograft Outcome by SHAH, Sapna, HARWOOD, Steven M, DÖHLER, Bernd, OPELZ, Gerhard, YAQOOB, Muhammad M

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Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment by Kieswich, Julius, Sayers, Sophie R., Silvestre, Marta F., Harwood, Steven M., Yaqoob, Muhammad M., Caton, Paul W.

“…Aims/hypothesis Serum extracellular nicotinamide phosphoribosyltransferase (eNAMPT) concentrations are elevated in type 2 diabetes. However, the relationship…”
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Inosine monophosphate dehydrogenase polymorphisms and renal allograft outcome by Shah, Sapna, Harwood, Steven M, Döhler, Bernd, Opelz, Gerhard, Yaqoob, Muhammad M

“…Interindividual variation in inosine monophosphate dehydrogenase (IMPDH) enzyme activity and adverse effects caused by mycophenolate mofetil (MMF) inhibition…”
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Aging and uremia:Is there cellular and molecular crossover? by White, William E, Yaqoob, Muhammad M, Harwood, Steven M

“…Many observers have noted that the morphological changes that occur in chronic kidney disease(CKD) patients resemble those seen in the geriatric population,…”
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Myocardial bioenergetic abnormalities in experimental uremia by Chesser, Alistair Ms, Harwood, Steven M, Raftery, Martin J, Yaqoob, Muhammad M

“…Cardiac bioenergetics are known to be abnormal in experimental uremia as exemplified by a reduced phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio…”
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Albumin stimulates cell growth, L-arginine transport, and metabolism to polyamines in human proximal tubular cells by Ashman, Neil, Harwood, Steven M., Kieswich, Julius, Allen, David A., Roberts, Norman B., Mendes-Ribeiro, A. Claudio, Yaqoob, Muhammad M.

“…Albumin stimulates cell growth, L-arginine transport, and metabolism to polyamines in human proximal tubular cells. Pure albumin stimulates proximal tubular…”
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Calpain is a mediator of myocardial injury in experimental uremia: Is it activated by endogenous ouabain? by Harwood, Steven M., Allen, David A., Raftery, Martin J., Yaqoob, Muhammad M.

“…Calpain is a mediator of myocardial injury in experimental uremia: Is it activated by endogenous ouabain? Incidence of cardiovascular disease is more than…”
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Calpain is activated in experimental uremia: Is calpain a mediator of uremia-induced myocardial injury? by Harwood, Steven M., Allen, David A., Chesser, Alistair M.S., New, David I., Raftery, Martin J., Yaqoob, Muhammad M.

“…Calpain is activated in experimental uremia: Is calpain a mediator of uremia-induced myocardial injury? The cysteine proteases calpain and caspase-3 are known…”
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High glucose‐induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases by Allen, David A., Harwood, Steven M., Varagunam, Mira, Raftery, Martin J., Yaqoob, Muhammad M.

“…ABSTRACT Diabetic nephropathy is the leading cause of end‐stage renal disease in the Western world. Poor glycemic control contributes to the development of…”
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Elevated hepatic 11[Beta]-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia by Chapagain, Ananda, Caton, Paul W, Kieswich, Julius, Andrikopoulos, Petros, Nayuni, Nanda, Long, Jamie H, Harwood, Steven M, Webster, Scott P, Raftery, Martin J, Thiemermann, Christoph, Walker, Brian R, Seckl, Jonathan R, Corder, Roger, Yaqoob, Muhammad Magdi

“…Insulin resistance and associated metabolic sequelae are common in chronic kidney disease (CKD) and are positively and independently associated with increased…”
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Enhanced natriuretic response to neutral endopeptidase inhibition in patients with moderate chronic renal failure by Lipkin, Graham W., Dawnay, Anne B.S., Harwood, Steven M., Cattell, William R., Raine, Anthony E.G.

“…Enhanced natriuretic response to neutral endopeptidase inhibition in patients with moderate chronic renal failure. Atrial natriuretic factor (ANF) has…”
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Acute reversal of cyclosporine nephrotoxicity by neutral endopeptidase inhibition in stable renal transplant recipients by LIPKIN, G. W, THURAISINGHAM, R, DAWNAY, A. B. S, HARWOOD, S. M, RAINE, A. E. G

“…Atrial natriuretic peptide and cyclosporine have opposing effects on renal hemodynamics and excretory function. Twelve male stable cyclosporine-treated renal…”
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