Search Results - "HARWOOD, Steven"

Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin d deficiency: an exploratory, double blind, randomised controlled trial by Dreyer, Gavin, Tucker, Arthur T, Harwood, Steven M, Pearse, Rupert M, Raftery, Martin J, Yaqoob, Muhammad M

“…Vitamin D deficiency and endothelial dysfunction are non-traditional risk factors for cardiovascular events in chronic kidney disease. Previous studies in…”
Get full text

Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger by Andrikopoulos, Petros, Kieswich, Julius, Harwood, Steven M., Baba, Akemichi, Matsuda, Toshio, Barbeau, Olivier, Jones, Keith, Eccles, Suzanne A., Yaqoob, Muhammad M.

“…Thrombin acts on the endothelium by activating protease-activated receptors (PARs). The endothelial thrombin-PAR system becomes deregulated during pathological…”
Get full text

Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment by Kieswich, Julius, Sayers, Sophie R., Silvestre, Marta F., Harwood, Steven M., Yaqoob, Muhammad M., Caton, Paul W.

“…Aims/hypothesis Serum extracellular nicotinamide phosphoribosyltransferase (eNAMPT) concentrations are elevated in type 2 diabetes. However, the relationship…”
Get full text

Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications by Allen, David A., Yaqoob, Muhammad M., Harwood, Steven M.

“…Cellular responses to high glucose are numerous and varied but ultimately result in functional changes and, often, cell death. High glucose induces oxidative…”
Get full text

Inosine monophosphate dehydrogenase polymorphisms and renal allograft outcome by Shah, Sapna, Harwood, Steven M, Döhler, Bernd, Opelz, Gerhard, Yaqoob, Muhammad M

“…Interindividual variation in inosine monophosphate dehydrogenase (IMPDH) enzyme activity and adverse effects caused by mycophenolate mofetil (MMF) inhibition…”
Get full text

Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia by Chapagain, Ananda, Caton, Paul W., Kieswich, Julius, Andrikopoulos, Petros, Nayuni, Nanda, Long, Jamie H., Harwood, Steven M., Webster, Scott P., Raftery, Martin J., Thiemermann, Christoph, Walker, Brian R., Seckl, Jonathan R., Corder, Roger, Yaqoob, Muhammad Magdi

“…Insulin resistance and associated metabolic sequelae are common in chronic kidney disease (CKD) and are positively and independently associated with increased…”
Get full text

Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion by SHARPLES, Edward J, PATEL, Nimesh, THIEMERMANN, Christoph, YAQOOB, Muhammad M, BROWN, Paul, STEWART, Keith, MOTA-PHILIPE, Helder, SHEAFF, Michael, KIESWICH, Julius, ALLEN, David, HARWOOD, Steven, RAFTERY, Martin

“…Erythropoietin (EPO) is upregulated by hypoxia and causes proliferation and differentiation of erythroid progenitors in the bone marrow through inhibition of…”
Get full text

Dexamethasone Ameliorates Renal Ischemia-Reperfusion Injury by KUMAR, Sanjeev, ALLEN, David A, KIESWICH, Julius E, PATEL, Nimesh S. A, HARWOOD, Steven, MAZZON, Emanuela, CUZZOCREA, Salvatore, RAFTERY, Martin J, THIEMERMANN, Christoph, YAQOOB, Muhammad M

“…In the setting of renal ischemia-reperfusion injury (IRI), the effect and mechanism of action of glucocorticoids are not well understood. In rat renal IRI, a…”
Get full text

The MEK Inhibitor Trametinib Ameliorates Kidney Fibrosis by Suppressing ERK1/2 and mTORC1 Signaling by Andrikopoulos, Petros, Kieswich, Julius, Pacheco, Sabrina, Nadarajah, Luxme, Harwood, Steven Michael, O'Riordan, Caroline E, Thiemermann, Christoph, Yaqoob, Muhammad M

“…During kidney fibrosis, a hallmark and promoter of CKD (regardless of the underlying renal disorder leading to CKD), the extracellular-regulated kinase 1/2…”
Get full text

Ischemic Conditioning Protects the Uremic Heart in a Rodent Model of Myocardial Infarction by BYRNE, Conor J, MCCAFFERTY, Kieran, KIESWICH, Julius, HARWOOD, Steven, ANDRIKOPOULOS, Petros, RAFTERY, Martin, THIEMERMANN, Christoph, YAQOOB, Muhammad M

“…Outcomes after acute myocardial infarction in patients with chronic kidney disease are extremely poor. Ischemic conditioning techniques are among the most…”
Get full text

Treating Posttransplant Anemia With Erythropoietin Improves Quality of Life but Does Not Affect Progression of Chronic Kidney Disease by Pile, Taryn, Raftery, Martin, Thuraisingham, Raj, Kirwan, Christopher J., Harwood, Steven, Yaqoob, Muhammed M.

“…Objectives: Posttransplant anemia affects 30% to 45% of kidney transplant recipients and is associated with increased morbidity. However, there is lack of…”
Get full text

Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis by Harwood, Steven M, Yaqoob, Muhammad M, Allen, David A

“…Calpain and caspase are families of cysteine proteases that have important roles in the initiation, regulation and execution of cell death. The function of…”
Get more information

High glucose‐induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases by Allen, David A., Harwood, Steven M., Varagunam, Mira, Raftery, Martin J., Yaqoob, Muhammad M.

“…ABSTRACT Diabetic nephropathy is the leading cause of end‐stage renal disease in the Western world. Poor glycemic control contributes to the development of…”
Get full text

The AcMNPV pp31 gene is not essential for productive AcMNPV replication or late gene transcription but appears to increase levels of most viral transcripts by Yamagishi, Junya, Burnett, Erik D, Harwood, Steven H, Blissard, Gary W

“…Abstract The pp31 gene of Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) encodes a phosphorylated DNA binding protein that associates with…”
Get full text

Inosine Monophosphate Dehydrogenase Polymorphisms and Renal Allograft Outcome by SHAH, Sapna, HARWOOD, Steven M, DÖHLER, Bernd, OPELZ, Gerhard, YAQOOB, Muhammad M

Get full text

Myocardial bioenergetic abnormalities in experimental uremia by Chesser, Alistair Ms, Harwood, Steven M, Raftery, Martin J, Yaqoob, Muhammad M

“…Cardiac bioenergetics are known to be abnormal in experimental uremia as exemplified by a reduced phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio…”
Get full text

Albumin stimulates cell growth, L-arginine transport, and metabolism to polyamines in human proximal tubular cells by Ashman, Neil, Harwood, Steven M., Kieswich, Julius, Allen, David A., Roberts, Norman B., Mendes-Ribeiro, A. Claudio, Yaqoob, Muhammad M.

“…Albumin stimulates cell growth, L-arginine transport, and metabolism to polyamines in human proximal tubular cells. Pure albumin stimulates proximal tubular…”
Get full text

Aging and uremia:Is there cellular and molecular crossover? by White, William E, Yaqoob, Muhammad M, Harwood, Steven M

“…Many observers have noted that the morphological changes that occur in chronic kidney disease(CKD) patients resemble those seen in the geriatric population,…”
Get full text

Calpain is a mediator of myocardial injury in experimental uremia: Is it activated by endogenous ouabain? by Harwood, Steven M., Allen, David A., Raftery, Martin J., Yaqoob, Muhammad M.

“…Calpain is a mediator of myocardial injury in experimental uremia: Is it activated by endogenous ouabain? Incidence of cardiovascular disease is more than…”
Get full text

Use of Sulesomab, a Radiolabeled Antibody Fragment, to Detect Osteomyelitis in Diabetic Patients with Foot Ulcers by Leukoscintigraphy by Harwood, Steven J., Valdivia, Sonia, Hung, Guo-Long, Quenzer, Ronald W.

“…Diabetic patients suspected of having osteomyelitis secondary to foot ulcers underwent scintigraphic imaging with Sulesomab, an anti-granulocyte antibody Fab'…”
Get full text