Search Results - "HARVIMA, I. T."

Experimentally induced psoriatic lesion associates with interleukin (IL)‐6 in mast cells and appearance of dermal cells expressing IL‐33 and IL‐6 receptor by Suttle, M.‐M., Nilsson, G., Snellman, E., Harvima, I. T.

“…Summary Mast cells are involved in the development of psoriatic lesion, but it is not known how mast cells are activated or whether mast cell cytokines are…”
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Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-α and their degranulation is associated with expression of ICAM-1 in the epidermis by ACKERMANN, L, HARVIMA, I. T

“…The release of cytokines from cutaneous cells may be of major importance in the initiation and development of many inflammatory skin disorders. For example,…”
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Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is controlled by proteinase inhibitors by Huttunen, M., Harvima, I.T.

“…Summary Background  Numerous mast cells are present in chronic leg ulcers. Tryptase and chymase are the major mediators of mast cells, but their significance…”
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Mast cell chymase degrades fibrinogen and fibrin by Lipitsä, T., Siiskonen, H., Naukkarinen, A., Harvima, I.T.

“…Summary Background The accumulation of immunoreactants and fibrinoid necrosis of postcapillary vessel walls are common pathological features of cutaneous…”
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The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma by Diaconu, N-C, Kaminska, R, Naukkarinen, A, Harvima, RJ, Harvima, IT

“…Background  In basal cell carcinoma (BCC), mast cells accumulate in the peritumoral stroma. The serine proteinases tryptase and chymase are the major mediators…”
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OX40 ligand and OX40 are increased in atopic dermatitis lesions but do not correlate with clinical severity by Ilves, T., Harvima, I.T.

“…Background  The interaction between the OX40 ligand (OX40L) and OX40 has been suggested to have pathogenetic significance in atopic dermatitis (AD). Objective …”
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Mast cells in psoriatic skin are strongly positive for interferon-gamma by ACKERMANN, L, HARVIMA, I. T, PELKONEN, J, RITAMÄKI-SALO, V, NAUKKARINEN, A, HARVIMA, R. J, HORSMANHEIMO, M

“…The increased number and early activation of cutaneous mast cells is a typical feature of psoriatic inflammation. Interferon‐gamma (IFN‐γ) is believed to be…”
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Inhibition of keratinocyte growth in cell culture and whole skin culture by mast cell mediators by Huttunen, M., Hyttinen, M., Nilsson, G., Butterfield, J. H., Horsmanheimo, M., Harvima, I. T.

“…: Mast cells are suggested to participate in regenerative processes, but their influence on epithelialization and wound healing has not been well studied…”
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Alterations in mast cells showing tryptase and chymase activity in epithelializating and chronic wounds by Huttunen, M., Aalto, M.-L., Harvima, R. J., Horsmanheimo, M., Harvima, I. T.

“…: Mast cells can be found in contact with epidermis in certain circumstances; especially in chronic inflammatory skin diseases and chronic ulcers, but the…”
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The release of histamine is associated with the inactivation of mast cell chymase during immediate allergic wheal reaction in the skin by Saarinen, J. V., Harvima, R. J., Naukkarinen, A., Horsmanheimo, M., Harvima, I. T.

“…Background Chymase released by mast cells can participate in the immediate allergic wheal. However, chymase may be susceptible to inactivation by protease…”
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Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema by JÄRVIKALLIO, A., NAUKKARINEN, A., HARVIMA, I.T., AALTO, M.-L., HORSMANHEIMO, M.

“…Summary The distribution of mast cells (MCs) containing tryptase (T) and chymase (C) was studied in the non‐lesional and lesional skin of 26 patients with…”
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Interleukin‐4‐positive mast cells are highly associated with the extent of immediate allergic wheal reaction in the skin by Saarinen, J. V., Harvima, R. J., Horsmanheimo, M., Harvima, I. T., Naukkarinen, A.

“…Background: In addition to histamine, mast cells contain other potent mediators which can contribute to the allergic wheal reaction in the skin. Methods: To…”
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Focal Dermal–Epidermal Separation and Fibronectin Cleavage in Basement Membrane by Human Mast Cell Tryptase by Kaminska, Renata, Helisalmi, Petra, Harvima, Rauno J., Horsmanheimo, Maija, Harvima, Ilkka T, Naukkarinen, Anita

“…Mast cell proteases are believed to participate in the basement membrane destruction in blistering diseases. Thus, normal human skin specimens were incubated…”
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Staphylococcal enterotoxin B inhibits the production of interleukin‐4 in a human mast‐cell line HMC‐1 by Ackermann, L., Pelkonen, J., Harvima, I. T.

“…Staphylococcal enterotoxins belong to the recently characterized group of immunocytotropic bacterial superantigens that are potent mitogens for human T cells…”
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Histamine and LTC4 in stinging nettle‐induced urticaria by Taskila, K., Saarinen, J. V., Harvima, I. T., Harvima, R. J.

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Release of soluble tryptase but only minor amounts of chymase activity from cutaneous mast cells by Kivinen, P. K., Kaminska, R., Naukkarinen, A., Harvima, R. J., Horsmanheimo, M., Harvima, I. T.

“…: Tryptase and chymase are the major serine proteinases of skin mast cells but their biologic significance depends on their activity. In this study, we…”
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Mast cells are one major source of interleukin-4 in atopic dermatitis by Horsmanheimo, L, Harvima, I T, Järvikallio, A, Harvima, R J, Naukkarinen, A, Horsmanheimo, M

“…Several reports have shown the presence of T-helper lymphocytes with Th2 characteristics in the skin lesions of atopic dermatitis (AD). However, Th2 cells…”
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Modulation of the immediate allergic wheal reaction in the skin by drugs inhibiting the effects of leukotriene C4 and prostaglandin D2 by SAARINEN, J. V, HARVIMA, R. J, HORSMANHEIMO, M, HARVIMA, I. T

“…To study the effect of nordihydroguaiaretic acid (NDGA), zafirlukast and indomethacin on the size of the size of the allergic prick-test wheal. In the first…”
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QUANTITATIVE HISTOCHEMICAL ANALYSIS OF MAST CELLS AND SENSORY NERVES IN PSORIATIC SKIN by NAUKKARINEN, ANITA, JÄRVIKALLIO, ANITTA, LAKKAKORPI, JOUNI, HARVIMA, ILKKA T., HARVIMA, RAUNO J., HORSMANHEIMO, MAIJA

“…To study the elements of neurogenic inflammation in psoriatic skin, morphological contacts were examined between mast cells and sensory nerves containing the…”
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Role of mast cells and sensory nerves in skin inflammation by Harvima, I T, Nilsson, G, Naukkarinen, A

“…Mast cells are powerful inflammatory cells which are in close functional and anatomical association with sensory nerves in the skin. During psychological…”
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