Search Results - "HARVEY, R"

A Tumor Agnostic Therapeutic Strategy for Hexokinase 1-Null/Hexokinase 2-Positive Cancers by Xu, Shili, Herschman, Harvey R

“…Since Warburg's observation that most cancers exhibit elevated glycolysis, decades of research have attempted to reduce tumor glucose utilization as a…”
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The earlier the better? Or better late than never? Dose optimization in oncology by Harvey, R Donald

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Preventing and Managing Toxicities of High‐Dose Methotrexate by Howard, Scott C., McCormick, John, Pui, Ching‐Hon, Buddington, Randall K., Harvey, R. Donald

“…High‐dose methotrexate (HDMTX), defined as a dose higher than 500 mg/m2, is used to treat a range of adult and childhood cancers. Although HDMTX is safely…”
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Immunologic and Clinical Effects of Targeting PD-1 in Lung Cancer by Harvey, R D

“…Therapeutic antibodies that block the programmed cell death protein‐1 (PD‐1) immune checkpoint pathway prevent T‐cell downregulation and promote immune…”
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Links Between the Neurobiology of Oxytocin and Human Musicality by Harvey, Alan R.

“…The human species possesses two complementary, yet distinct, universal communication systems – language and music. Functional imaging studies have revealed…”
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Cancer, Inflammation, and Therapy: Effects on Cytochrome P450-Mediated Drug Metabolism and Implications for Novel Immunotherapeutic Agents by Harvey, R Donald, Morgan, E T

“…Immune system activation through innate and adaptive systemic mechanisms is critical for protection from pathogens and other antigens. However, uncontrolled…”
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The real effects of financial constraints: Evidence from a financial crisis by Campello, Murillo, Graham, John R., Harvey, Campbell R.

“…We survey 1,050 Chief Financial Officers (CFOs) in the U.S., Europe, and Asia to directly assess whether their firms are credit constrained during the global…”
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Integrated safety profile of single-agent carfilzomib: experience from 526 patients enrolled in 4 phase II clinical studies by Siegel, David, Martin, Thomas, Nooka, Ajay, Harvey, R Donald, Vij, Ravi, Niesvizky, Ruben, Badros, Ashraf Z, Jagannath, Sundar, McCulloch, Leanne, Rajangam, Kanya, Lonial, Sagar

“…Carfilzomib, a selective proteasome inhibitor, was approved in 2012 for the treatment of relapsed and refractory multiple myeloma. Safety data for single-agent…”
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MANAGERIAL MISCALIBRATION by Ben-David, Itzhak, Graham, John R., Harvey, Campbell R.

“…Using a unique 10-year panel that includes more than 13,300 expected stock market return probability distributions, we find that executives are severely…”
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Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer by Szmulewitz, Russell Z, Peer, Cody J, Ibraheem, Abiola, Martinez, Elia, Kozloff, Mark F, Carthon, Bradley, Harvey, R Donald, Fishkin, Paul, Yong, Wei Peng, Chiong, Edmund, Nabhan, Chadi, Karrison, Theodore, Figg, William D, Stadler, Walter M, Ratain, Mark J

“…Purpose Abiraterone acetate (AA) is a standard of care for metastatic castration-resistant prostate cancer (CRPC). Despite a large food effect, AA was…”
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Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche by Roulis, Manolis, Kaklamanos, Aimilios, Schernthanner, Marina, Bielecki, Piotr, Zhao, Jun, Kaffe, Eleanna, Frommelt, Laura-Sophie, Qu, Rihao, Knapp, Marlene S., Henriques, Ana, Chalkidi, Niki, Koliaraki, Vasiliki, Jiao, Jing, Brewer, J. Richard, Bacher, Maren, Blackburn, Holly N., Zhao, Xiaoyun, Breyer, Richard M., Aidinis, Vassilis, Jain, Dhanpat, Su, Bing, Herschman, Harvey R., Kluger, Yuval, Kollias, George, Flavell, Richard A.

“…The initiation of an intestinal tumour is a probabilistic process that depends on the competition between mutant and normal epithelial stem cells in crypts 1 …”
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Capital allocation and delegation of decision-making authority within firms by Graham, John R., Harvey, Campbell R., Puri, Manju

“…We use a unique data set that contains information on more than 1,000 Chief Executive Officers (CEOs) and Chief Financial Officers (CFOs) around the world to…”
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The economic implications of corporate financial reporting by Graham, John R., Harvey, Campbell R., Rajgopal, Shiva

“…We survey and interview more than 400 executives to determine the factors that drive reported earnings and disclosure decisions. We find that managers would…”
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Afatinib for the treatment of EGFR mutation-positive NSCLC: A review of clinical findings by Harvey, R Donald, Adams, Val R, Beardslee, Tyler, Medina, Patrick

“…Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors represent the standard of care in patients with EGFR mutation-positive (EGFRm+) non-small…”
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Quark Mass Models and Reinforcement Learning by Harvey, T. R., Lukas, A.

“…A bstract In this paper, we apply reinforcement learning to the problem of constructing models in particle physics. As an example environment, we use the space…”
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Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling by Li, Hua-Jung, Reinhardt, Ferenc, Herschman, Harvey R, Weinberg, Robert A

“…Mesenchymal cells of the tumor-associated stroma are critical determinants of carcinoma cell behavior. We focus here on interactions of carcinoma cells with…”
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Withaferin A inhibits breast cancer invasion and metastasis at sub‐cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation by Thaiparambil, Jose T., Bender, Laura, Ganesh, Thota, Kline, Erik, Patel, Pritty, Liu, Yuan, Tighiouart, Mourad, Vertino, Paula M., Harvey, R. Donald, Garcia, Anapatricia, Marcus, Adam I.

“…Withaferin A (WFA) is purified from the plant Withania somnifera and inhibits the vimentin cytoskeleton. Vimentin overexpression in cancer correlates with…”
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Ion Channels Controlling Circadian Rhythms in Suprachiasmatic Nucleus Excitability by Harvey, Jenna R M, Plante, Amber E, Meredith, Andrea L

“…Animals synchronize to the environmental day-night cycle by means of an internal circadian clock in the brain. In mammals, this timekeeping mechanism is housed…”
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The prevalence and causes of dementia in people under the age of 65 years by Harvey, R J, Skelton-Robinson, M, Rossor, M N

“…Objectives: To determine the prevalence of dementia in people under the age of 65 in a large catchment area, and use these figures to estimate the number of…”
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Low-cost, sub-micron resolution, wide-field computational microscopy using opensource hardware by Aidukas, Tomas, Eckert, Regina, Harvey, Andrew R., Waller, Laura, Konda, Pavan C.

“…The revolution in low-cost consumer photography and computation provides fertile opportunity for a disruptive reduction in the cost of biomedical imaging…”
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