Search Results - "HARVEY, Mario"

Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo by Kulhankova, Katarina, Traore, Soumba, Cheng, Xue, Benk-Fortin, Hadrien, Hallée, Stéphanie, Harvey, Mario, Roberge, Joannie, Couture, Frédéric, Kohli, Sajeev, Gross, Thomas J., Meyerholz, David K., Rettig, Garrett R., Thommandru, Bernice, Kurgan, Gavin, Wohlford-Lenane, Christine, Hartigan-O’Connor, Dennis J., Yates, Bradley P., Newby, Gregory A., Liu, David R., Tarantal, Alice F., Guay, David, McCray, Paul B.

“…Gene editing strategies for cystic fibrosis are challenged by the complex barrier properties of airway epithelia. We previously reported that the amphiphilic…”
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KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors by Mac Donald, Alice, Guipouy, Delphine, Lemieux, William, Harvey, Mario, Bordeleau, Louis-Jean, Guay, David, Roméro, Hugo, Li, Yuanyi, Dion, Renaud, Béland, Kathie, Haddad, Elie

“…Natural Killer (NK) cells hold the potential to shift cell therapy from a complex autologous option to a universal off-the-shelf one. Although NK cells have…”
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Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer by Gonthier, Kevin, Weidmann, Cindy, Berthiaume, Line, Jobin, Cynthia, Lacouture, Aurélie, Lafront, Camille, Harvey, Mario, Neveu, Bertrand, Loehr, Jérémy, Bergeron, Alain, Fradet, Yves, Lacombe, Louis, Riopel, Julie, Latulippe, Éva, Atallah, Chantal, Shum, Michael, Lambert, Jean-Philippe, Pouliot, Frédéric, Pelletier, Martin, Audet-Walsh, Étienne

“…The androgen receptor (AR) is an established orchestrator of cell metabolism in prostate cancer (PCa), notably by inducing an oxidative mitochondrial program…”
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Glucuronidation of the Antiretroviral Drug Efavirenz by UGT2B7 and an in Vitro Investigation of Drug-Drug Interaction with Zidovudine by BELANGER, Anne-Sophie, CARON, Patrick, HARVEY, Mario, ZIMMERMAN, Peter A, MEHLOTRA, Rajeev K, GUILLEMETTE, Chantal

“…The non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) is directly conjugated by the UDP-glucuronosyltransferase (UGT) pathway to form EFV- N…”
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Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion by Frégeau-Proulx, Lilianne, Lacouture, Aurélie, Berthiaume, Line, Weidmann, Cindy, Harvey, Mario, Gonthier, Kevin, Pelletier, Jean-François, Neveu, Bertrand, Jobin, Cynthia, Bastien, Dominic, Bergeron, Alain, Fradet, Yves, Lacombe, Louis, Laverdière, Isabelle, Atallah, Chantal, Pouliot, Frédéric, Audet-Walsh, Étienne

“…The prostate is metabolically unique: it produces high levels of citrate for secretion via a truncated tricarboxylic acid (TCA) cycle to maintain male…”
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Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells by Bélanger, Anne-Sophie, Tojcic, Jelena, Harvey, Mario, Guillemette, Chantal

“…UDP-glucuronosyltransferase 1A1 (UGT1A1) is a pivotal enzyme involved in metabolism of SN-38, the active metabolite of irinotecan commonly used to treat…”
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Modulation of the Human Glucuronosyltransferase UGT1A Pathway by Splice Isoform Polypeptides Is Mediated through Protein-Protein Interactions by Bellemare, Judith, Rouleau, Mélanie, Harvey, Mario, Guillemette, Chantal

“…This study investigated the molecular mechanisms underlying the regulatory effect of the newly discovered 45-kDa enzymatically inactive UGT1A spliced…”
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Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder by Barden, Nicholas, Harvey, Mario, Gagné, Bernard, Shink, Eric, Tremblay, Monique, Raymond, Catherine, Labbé, Michel, Villeneuve, André, Rochette, Denis, Bordeleau, Lise, Stadler, Herbert, Holsboer, Florian, Müller-Myhsok, Bertram

“…Previous results from our genetic analyses using pedigrees from a French Canadian population suggested that the interval delimited by markers on chromosome 12,…”
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Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans by Bellemare, Judith, Rouleau, Mélanie, Harvey, Mario, Popa, Ion, Pelletier, Georges, Têtu, Bernard, Guillemette, Chantal

“…Glucuronidation by UDP‐glucuronyltransferase (UGT) enzymes is the prevailing conjugative pathway for the metabolism of both xenobiotics and endogenous…”
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Intralesional Treatment of Basal Cell Carcinoma in a Genetically Inducible Mouse Model by Messier, Nancy, Couture, Frédéric, Théberge, Vanessa, Harvey, Mario, Kobayashi, Kenneth

“…Introduction: Patients with nevoid basal cell carcinoma syndrome (NBCCS), also termed Gorlin syndrome, develop numerous basal cell carcinomas (BCCs). Current…”
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UGT genomic diversity: beyond gene duplication by Guillemette, Chantal, Lévesque, Eric, Harvey, Mario, Bellemare, Judith, Menard, Vincent

“…The human uridine diphospho (UDP)-glucuronosyltransferase (UGT) superfamily comprises enzymes responsible for a major biotransformation phase II pathway: the…”
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Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells by Kulhankova, Katarina, Cheng, Anna X, Traore, Soumba, Auger, Maud, Pelletier, Mia, Hervault, Maxime, Wells, Kevin D, Green, Jonathan A, Byrne, Addison, Nelson, Benjamin, Sponchiado, Mariana, Boosani, Chandra, Heffner, Caleb S, Snow, Kathy J, Murray, Stephen A, Villacreses, Raul A, Rector, Michael V, Gansemer, Nicholas D, Stoltz, David A, Allamargot, Chantal, Couture, Frédéric, Hemez, Colin, Hallée, Stéphanie, Barbeau, Xavier, Harvey, Mario, Lauvaux, Coraline, Gaillet, Bruno, Newby, Gregory A, Liu, David R, McCray, Jr, Paul B, Guay, David

“…Base editing could correct nonsense mutations that cause cystic fibrosis (CF), but clinical development is limited by the lack of delivery methods that…”
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Protocol for transducing human primary epithelial prostate cells and patient-derived organoids with high efficiency by Jobin, Cynthia, Harvey, Mario, Lacouture, Aurélie, Weidmann, Cindy, Neveu, Bertrand, Pouliot, Frédéric, Audet-Walsh, Étienne

“…Patient-derived organoids (PDOs) are now used to study many diseases, including prostate cancer. Here, we present a protocol for the transduction of human…”
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Protein-protein interactions between the bilirubin-conjugating UDP-glucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing by Rouleau, Mélanie, Collin, Pierre, Bellemare, Judith, Harvey, Mario, Guillemette, Chantal

“…The oligomerization of UGTs [UDP (uridine diphosphate)-glucuronosyltransferases] modulates their enzyme activities. Recent findings also indicate that…”
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Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens by Lévesque, Eric, Bélanger, Anne-Sophie, Harvey, Mario, Couture, Félix, Jonker, Derek, Innocenti, Federico, Cecchin, Erica, Toffoli, Giuseppe, Guillemette, Chantal

“…Despite the importance of UDP-glucuronosyltransferase (UGT) 1A1*28 in irinotecan pharmacogenetics, our capability to predict drug-induced severe toxicity…”
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In Vitro Investigation of Human UDP-Glucuronosyltransferase Isoforms Responsible for Tacrolimus Glucuronidation: Predominant Contribution of UGT1A4 by LAVERDIERE, Isabelle, CARON, Patrick, HARVEY, Mario, LEVESQUE, Eric, GUILLEMETTE, Chantal

“…Tacrolimus (Tacro) is a potent immunosuppressant and a central agent in the prevention of posttransplantation rejection. Tacro is characterized by a narrow…”
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P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder by Lucae, Susanne, Salyakina, Daria, Barden, Nicholas, Harvey, Mario, Gagné, Bernard, Labbé, Michel, Binder, Elisabeth B., Uhr, Manfred, Paez-Pereda, Marcelo, Sillaber, Inge, Ising, Marcus, Brückl, Tanja, Lieb, Roselind, Holsboer, Florian, Müller-Myhsok, Bertram

“…The P2RX7 gene is located within a region on chromosome 12q24.31 that has been identified as a susceptibility locus for affective disorders by linkage and…”
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Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants by Ménard, Vincent, Eap, Olivier, Roberge, Joannie, Harvey, Mario, Lévesque, Eric, Guillemette, Chantal

“…OBJECTIVEUGT2B7 is a key member of the UDP-glucuronosyltransferase (UGT) family that participates in glucuronidation of endogenous compounds and…”
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603. Feldan Shuttle - Advanced Protein Delivery Technology for Cell Therapy by Del'Guidice, Thomas, Lepetit-Stoffaes, Jean-Pascal, Roberge, Joannie, Bordeleau, Louis-Jean, Harvey, Mario, Garnier, Alain, Guay, David

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Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro by BELLEMARE, Judith, ROULEAU, Mélanie, GIRARD, Hugo, HARVEY, Mario, GUILLEMETTE, Chantal

“…UDP-glucuronosyltransferases (UGTs) are major mediators in conjugative metabolism. Current data suggest that UGTs, which are anchored in the endoplasmic…”
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