Search Results - "HARTMANN, Roland K"

Cleavage kinetics of human mitochondrial RNase P and contribution of its non-nuclease subunits by Vilardo, Elisa, Toth, Ursula, Hazisllari, Enxhi, Hartmann, Roland K, Rossmanith, Walter

“…Abstract RNase P is the endonuclease responsible for the 5′ processing of precursor tRNAs (pre-tRNAs). Unlike the single-subunit protein-only RNase P (PRORP)…”
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MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma by AHMED FAWZY IBRAHIM, WEIRAUCH, Ulrike, THOMAS, Maren, GRÜNWELLER, Arnold, HARTMANN, Roland K, AIGNER, Achim

“…MicroRNAs (miRNA) aberrantly expressed in tumors may offer novel therapeutic approaches to treatment. miR-145 is downregulated in various cancers including…”
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The previously uncharacterized RnpM (YlxR) protein modulates the activity of ribonuclease P in Bacillus subtilis in vitro by Wicke, Dennis, Neumann, Piotr, Gößringer, Markus, Chernev, Aleksandar, Davydov, Swetlana, Poehlein, Anja, Daniel, Rolf, Urlaub, Henning, Hartmann, Roland K, Ficner, Ralf, Stülke, Jörg

“…Abstract Even though Bacillus subtilis is one of the most studied organisms, no function has been identified for about 20% of its proteins. Among these unknown…”
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Led-Seq: ligation-enhanced double-end sequence-based structure analysis of RNA by Kolberg, Tim, von Löhneysen, Sarah, Ozerova, Iuliia, Wellner, Karolin, Hartmann, Roland K, Stadler, Peter F, Mörl, Mario

“…Abstract Structural analysis of RNA is an important and versatile tool to investigate the function of this type of molecules in the cell as well as in vitro…”
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Orthology detection combining clustering and synteny for very large datasets by Lechner, Marcus, Hernandez-Rosales, Maribel, Doerr, Daniel, Wieseke, Nicolas, Thévenin, Annelyse, Stoye, Jens, Hartmann, Roland K, Prohaska, Sonja J, Stadler, Peter F

“…The elucidation of orthology relationships is an important step both in gene function prediction as well as towards understanding patterns of sequence…”
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Hexamer phasing governs transcription initiation in the 3'-leader of Ebola virus by Bach, Simone, Biedenkopf, Nadine, Grünweller, Arnold, Becker, Stephan, Hartmann, Roland K

“…The genomic, bipartite replication promoter of Ebola virus (EBOV) consists of elements 1 (PE1) and 2 (PE2). PE1 (55 nt at the 3'-terminus) is separated from…”
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Nucleocapsids of the Rift Valley fever virus ambisense S segment contain an exposed RNA element in the center that overlaps with the intergenic region by Shalamova, Lyudmila, Barth, Patrick, Pickin, Matthew J., Kouti, Kiriaki, Ott, Benjamin, Humpert, Katharina, Janssen, Stefan, Lorenzo, Gema, Brun, Alejandro, Goesmann, Alexander, Hain, Torsten, Hartmann, Roland K., Rossbach, Oliver, Weber, Friedemann

“…Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen. Its RNA genome consists of two negative-sense segments (L and M) with one gene each, and…”
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Nuclear RNase P of Trypanosoma brucei: A Single Protein in Place of the Multicomponent RNA-Protein Complex by Taschner, Andreas, Weber, Christoph, Buzet, Aurélie, Hartmann, Roland K., Hartig, Andreas, Rossmanith, Walter

“…RNase P is the endonuclease that removes 5′ extensions from tRNA precursors. In its best-known form, the enzyme is composed of a catalytic RNA and a protein…”
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Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (−) and the eIF4A-inhibitor Silvestrol by Müller, Christin, Obermann, Wiebke, Schulte, Falk W., Lange-Grünweller, Kerstin, Oestereich, Lisa, Elgner, Fabian, Glitscher, Mirco, Hildt, Eberhard, Singh, Kamini, Wendel, Hans-Guido, Hartmann, Roland K., Ziebuhr, John, Grünweller, Arnold

“…Rocaglates, a class of natural compounds isolated from plants of the genus Aglaia, are potent inhibitors of translation initiation. They are proposed to form…”
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The rocaglate CR-31-B (−) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo by Müller, Christin, Obermann, Wiebke, Karl, Nadja, Wendel, Hans-Guido, Taroncher-Oldenburg, Gaspar, Pleschka, Stephan, Hartmann, Roland K., Grünweller, Arnold, Ziebuhr, John

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, a severe respiratory disease with varying clinical…”
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2'-Fluoro-Pyrimidine-Modified RNA Aptamers Specific for Lipopolysaccharide Binding Protein (LBP) by Aldag, Jasmin, Persson, Tina, Hartmann, Roland K

“…Lipopolysaccaride binding protein (LBP), a glycosylated acute phase protein, plays an important role in the pathophysiology of sepsis. LBP binds with high…”
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RNA Binding of Ebola Virus VP30 Is Essential for Activating Viral Transcription by Biedenkopf, Nadine, Schlereth, Julia, Grünweller, Arnold, Becker, Stephan, Hartmann, Roland K

“…The template for Ebola virus (EBOV) transcription and replication is the helical viral nucleocapsid composed of the viral negative-sense (-) RNA genome, which…”
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Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites by Yu, Yanan, Fucini, Paola, Sanbonmatsu, Karissa Y, Wilson, Daniel N, Starosta, Agata L, Onuchic, José N, Mikolajka, Aleksandra, Brünner, Matthias, Hildebrand, Peter W, Ratje, Andreas H, Connell, Sean R, Penczek, Pawel A, Spahn, Christian M. T, Loerke, Justus, Dönhöfer, Alexandra, Whitford, Paul C, Mielke, Thorsten, Hartmann, Roland K

“…The elongation cycle of protein synthesis involves the delivery of aminoacyl-transfer RNAs to the aminoacyl-tRNA-binding site (A site) of the ribosome,…”
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Functional Role and Therapeutic Potential of the Pim-1 Kinase in Colon Carcinoma by Weirauch, Ulrike, Beckmann, Nadine, Thomas, Maren, Grünweller, Arnold, Huber, Kilian, Bracher, Franz, Hartmann, Roland K, Aigner, Achim

“…Abstract PURPOSE: The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to…”
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Identification and characterization of short leader and trailer RNAs synthesized by the Ebola virus RNA polymerase by Bach, Simone, Demper, Jana-Christin, Klemm, Paul, Schlereth, Julia, Lechner, Marcus, Schoen, Andreas, Kämper, Lennart, Weber, Friedemann, Becker, Stephan, Biedenkopf, Nadine, Hartmann, Roland K

“…Transcription of non-segmented negative sense (NNS) RNA viruses follows a stop-start mechanism and is thought to be initiated at the genome’s very 3’-end. The…”
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Substrate recognition and cleavage-site selection by a single-subunit protein-only RNase P by Brillante, Nadia, Gößringer, Markus, Lindenhofer, Dominik, Toth, Ursula, Rossmanith, Walter, Hartmann, Roland K

“…RNase P is the enzyme that removes 5' extensions from tRNA precursors. With its diversity of enzyme forms-either protein- or RNA-based, ranging from single…”
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Structure and mechanistic features of the prokaryotic minimal RNase P by Feyh, Rebecca, Waeber, Nadine B, Prinz, Simone, Giammarinaro, Pietro Ivan, Bange, Gert, Hochberg, Georg, Hartmann, Roland K, Altegoer, Florian

“…Endonucleolytic removal of 5’-leader sequences from tRNA precursor transcripts (pre-tRNAs) by ribonuclease P (RNase P) is essential for protein synthesis…”
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Involvement of E. coli 6S RNA in Oxidative Stress Response by Burenina, Olga Y, Elkina, Daria A, Ovcharenko, Anna, Bannikova, Valeria A, Schlüter, M Amri C, Oretskaya, Tatiana S, Hartmann, Roland K, Kubareva, Elena A

“…6S RNA, a small non-coding RNA present in almost all bacteria, inhibits transcription via direct binding to RNA polymerase holoenzymes. The mechanism of 6S RNA…”
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Site-Specific Cleavage of RNAs Derived from the PIM1 3'-UTR by a Metal-Free Artificial Ribonuclease by Zellmann, Felix, Thomas, Laura, Scheffer, Ute, Hartmann, Roland K, Göbel, Michael W

“…Oligonucleotide conjugates of tris(2-aminobenzimidazole) have been reported previously to cleave complementary RNA strands with high levels of sequence and…”
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Playing RNase P evolution: swapping the RNA catalyst for a protein reveals functional uniformity of highly divergent enzyme forms by Weber, Christoph, Hartig, Andreas, Hartmann, Roland K, Rossmanith, Walter

“…The RNase P family is a diverse group of endonucleases responsible for the removal of 5' extensions from tRNA precursors. The diversity of enzyme forms finds…”
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