Search Results - "HARTMANN, Pia"

LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages by Stephan, Alexander, Batinica, Marina, Steiger, Julia, Hartmann, Pia, Zaucke, Frank, Bloch, Wilhelm, Fabri, Mario

“…Summary As part of the innate host response neutrophils release neutrophil extracellular traps (NETs), protein:DNA complexes that contain a number of…”
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Selection of an HLA-C03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa by Hölzemer, Angelique, Thobakgale, Christina F, Jimenez Cruz, Camilo A, Garcia-Beltran, Wilfredo F, Carlson, Jonathan M, van Teijlingen, Nienke H, Mann, Jaclyn K, Jaggernath, Manjeetha, Kang, Seung-gu, Körner, Christian, Chung, Amy W, Schafer, Jamie L, Evans, David T, Alter, Galit, Walker, Bruce D, Goulder, Philip J, Carrington, Mary, Hartmann, Pia, Pertel, Thomas, Zhou, Ruhong, Ndung'u, Thumbi, Altfeld, Marcus

“…Viruses can evade immune surveillance, but the underlying mechanisms are insufficiently understood. Here, we sought to understand the mechanisms by which…”
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Relevance of the Organic Cation Transporters 1 and 2 for Antiretroviral Drug Therapy in Human Immunodeficiency Virus Infection by JUNG, Norma, LEHMANN, Clara, RUBBERT, Andrea, KNISPEL, Meike, HARTMANN, Pia, VAN LUNZEN, Jan, STELLBRINK, Hans-Juergen, FAETKENHEUER, Gerd, TAUBERT, Dirk

“…Carrier-mediated transport across cell membranes is an important determinant of activity, resistance, and toxicity of chemotherapeutic agents including…”
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Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients by Lehmann, Clara, Lafferty, Mark, Garzino-Demo, Alfredo, Jung, Norma, Hartmann, Pia, Fätkenheuer, Gerd, Wolf, Jeffrey S, van Lunzen, Jan, Romerio, Fabio

“…Circulating plasmacytoid dendritic cells (pDC) decline during HIV-1 infection, but at the same time they express markedly higher levels of interferon alpha…”
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Quantitation of Azoles and Echinocandins in Compartments of Peripheral Blood by Liquid Chromatography-Tandem Mass Spectrometry by FAROWSKI, Fedja, CORNELY, Oliver A, VEHRESCHILD, Jörg J, HARTMANN, Pia, BAUER, Tim, STEINBACH, Angela, RÜPING, Maria J. G. T, MÜLLER, Carsten

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Incorporation of Antigens into Viral Capsids Augments Immunogenicity of Adeno-Associated Virus Vector-Based Vaccines by RYBNIKER, Jan, NOWAG, Angela, JANICKI, Hanna, DEMANT, Kai, HARTMANN, Pia, BÜNING, Hildegard

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Intracellular Concentrations of Posaconazole in Different Compartments of Peripheral Blood by FAROWSKI, Fedja, CORNELY, Oliver A, VEHRESCHILD, Jörg J, HARTMANN, Pia, BAUER, Tim, STEINBACH, Angela, RÜPING, Maria J. G. T, MÜLLER, Carsten

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Nucleoside-free boosted double PI regimen: significant CD4+ T-cell recovery in patients with poor immunologic response despite virologic suppression by Lehmann, Clara, Jung, Norma, Hofmann, Anika, Cornely, Oliver A, Wyen, Christoph, Fätkenheuer, Gerd, Hartmann, Pia

“…Antiretroviral therapy in human immunodeficiency virus infection is occasionally associated with poor immunologic responses despite full suppression of viral…”
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A powerful DNA extraction method and PCR for detection of microsporidia in clinical stool specimens by Müller, A, Stellermann, K, Hartmann, P, Schrappe, M, Fätkenheuer, G, Salzberger, B, Diehl, V, Franzen, C

“…The diagnosis of intestinal microsporidiosis has traditionally depended on direct visualization of the parasite in stool specimens or intestinal biopsy samples…”
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Phagocytosis and killing of Mycobacterium avium complex by human neutrophils by Hartmann, P, Becker, R, Franzen, C, Schell-Frederick, E, Römer, J, Jacobs, M, Fätkenheuer, G, Plum, G

“…Organisms belonging to the Mycobacterium avium complex (MAC) cause life‐threatening bacteremia in immunocompromised patients. Monocytes and macrophages are…”
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High Intracellular Concentrations of Posaconazole Do Not Impact on Functional Capacities of Human Polymorphonuclear Neutrophils and Monocyte-Derived Macrophages In Vitro by Farowski, Fedja, Cornely, Oliver A, Hartmann, Pia

“…Posaconazole is a commonly used antifungal for the prophylaxis and treatment of invasive fungal infections. We previously demonstrated that the intracellular…”
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Insights into the function of the WhiB‐like protein of mycobacteriophage TM4 – a transcriptional inhibitor of WhiB2 by Rybniker, Jan, Nowag, Angela, Van Gumpel, Edeltraud, Nissen, Nicole, Robinson, Nirmal, Plum, Georg, Hartmann, Pia

“…Summary WhiB‐like proteins of actinomycetes are known to co‐ordinate iron‐sulfur (Fe‐S) clusters and are believed to have regulatory functions in many…”
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Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection by Beyer, Marc, Abdullah, Zeinab, Chemnitz, Jens M, Maisel, Daniela, Sander, Jil, Lehmann, Clara, Thabet, Yasser, Shinde, Prashant V, Schmidleithner, Lisa, Köhne, Maren, Trebicka, Jonel, Schierwagen, Robert, Hofmann, Andrea, Popov, Alexey, Lang, Karl S, Oxenius, Annette, Buch, Thorsten, Kurts, Christian, Heikenwalder, Mathias, Fätkenheuer, Gerd, Lang, Philipp A, Hartmann, Pia, Knolle, Percy A, Schultze, Joachim L

“…Functional T cell exhaustion occurs during chronic viral infection or in tumor settings. Beyer et al . report that chronic inflammation mediated by the…”
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T-cells of invasive candidiasis patients show patterns of T-cell-exhaustion suggesting checkpoint blockade as treatment option by Mellinghoff, Sibylle C., Thelen, Martin, Bruns, Christiane, Garcia-Marquez, Maria, Hartmann, Pia, Lammertz, Tatjana, Lehmann, Jonas, Nowag, Angela, Stemler, Jannik, Wennhold, Kerstin, Cornely, Oliver A., von Bergwelt-Baildon, Michael S., Schlößer, Hans A.

“…Recent data imply that strengthening host immunity by checkpoint inhibition improves outcome in invasive fungal infections (IFI), particularly in candidiasis…”
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Immunologically Confirmed Disseminated, Asymptomatic Encephalitozoon cuniculi Infection of the Gastrointestinal Tract in a Patient with AIDS by Franzen, Caspar, Schwartz, David A., Visvesvara, Govinda S., Müller, Andreas, Schwenk, Achim, Salzberger, Bernd, Fätkenheuer, Gerd, Hartmann, Pia, Mahrle, Gustav, Diehl, Volker, Schrappe, Matthias

“…Microsporidia are obligate intracellular protozoan parasites that infect a broad range of vertebrates and invertebrates. They are increasingly recognized as…”
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Analyzing candidemia guideline adherence identifies opportunities for antifungal stewardship by Mellinghoff, Sibylle C., Hartmann, Pia, Cornely, Florian B., Knauth, Laura, Köhler, Felix, Köhler, Philipp, Krause, Carolin, Kronenberg, Christine, Kranz, Sarah-Leonie, Menon, Vidya, Müller, Hannah, Naendrup, Jan-Hendrik, Pützfeld, Stefan, Ronge, Anna, Rutz, Jule, Seidel, Danila, Wisplinghoff, Hilmar, Cornely, Oliver A.

“…Candidemia epidemiology varies significantly by region; thus, local data are essential for evidence-based decision-making in prophylaxis and treatment. Current…”
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Repurposing QuantiFERON for Detection of Neutralizing Interferon-γ Autoantibodies in Patients With Nontuberculous Mycobacterial Infections by Suárez, Isabelle, Lehmann, Clara, Gruell, Henning, Graeb, Jessica, Kochanek, Matthias, Fätkenheuer, Gerd, Plum, Georg, van Wengen, Annelies, van de Vosse, Esther, Hartmann, Pia, Hanitsch, Leif G., Rybniker, Jan

“…Nontuberculous mycobacterial infections due to autoantibodies targeting interferon-γ are an emerging medical problem. However, case finding is hampered due to…”
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Treatment of MDR, Pre-XDR, XDR, and Rifampicin-Resistant Tuberculosis or in Case of Intolerance to at Least Rifampicin in Austria, Germany, and Switzerland by Otto-Knapp, Ralf, Bauer, Torsten, Brinkmann, Folke, Feiterna-Sperling, Cornelia, Friesen, Inna, Geerdes-Fenge, Hilte, Hartmann, Pia, Häcker, Brit, Heyckendorf, Jan, Kuhns, Martin, Lange, Christoph, Maurer, Florian P, Nienhaus, Albert, Priwitzer, Martin, Richter, Elvira, Salzer, Helmut J F, Schoch, Otto D, Schönfeld, Nicolas, Schaberg, Tom

“…Based on the assessment of new evidence, the World Health Organization (WHO) updated its guidelines for the treatment of drug-resistant tuberculosis (TB) in…”
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The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defence by Rybniker, Jan, Pojer, Florence, Marienhagen, Jan, Kolly, Gaëlle S, Chen, Jeffrey M, van Gumpel, Edeltraud, Hartmann, Pia, Cole, Stewart T

“…The complex multiprotein systems for the assembly of protein-bound iron-sulfur (Fe-S) clusters are well defined in Gram-negative model organisms. However,…”
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Low prevalence of DHFR and DHPS mutations in Pneumocystis jirovecii strains obtained from a German cohort by Suárez, Isabelle, Roderus, Lisa, van Gumpel, Edeltraud, Jung, Norma, Lehmann, Clara, Fätkenheuer, Gerd, Hartmann, Pia, Plum, Georg, Rybniker, Jan

“…Background Pneumocystis pneumonia (PCP) is an opportunistic and potentially life-threatening infection of immunocompromised individuals. A combination of…”
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