Search Results - "HARTMANN, Luise"

Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia by Metzeler, Klaus H., Herold, Tobias, Rothenberg-Thurley, Maja, Amler, Susanne, Sauerland, Maria C., Görlich, Dennis, Schneider, Stephanie, Konstandin, Nikola P., Dufour, Annika, Bräundl, Kathrin, Ksienzyk, Bianka, Zellmeier, Evelyn, Hartmann, Luise, Greif, Philipp A., Fiegl, Michael, Subklewe, Marion, Bohlander, Stefan K., Krug, Utz, Faldum, Andreas, Berdel, Wolfgang E., Wörmann, Bernhard, Büchner, Thomas, Hiddemann, Wolfgang, Braess, Jan, Spiekermann, Karsten

“…The clinical and prognostic relevance of many recently identified driver gene mutations in adult acute myeloid leukemia (AML) is poorly defined. We sequenced…”
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Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis by Herold, Tobias, Schneider, Stephanie, Metzeler, Klaus H, Neumann, Martin, Hartmann, Luise, Roberts, Kathryn G, Konstandin, Nikola P, Greif, Philipp A, Bräundl, Kathrin, Ksienzyk, Bianka, Huk, Natalia, Schneider, Irene, Zellmeier, Evelyn, Jurinovic, Vindi, Mansmann, Ulrich, Hiddemann, Wolfgang, Mullighan, Charles G, Bohlander, Stefan K, Spiekermann, Karsten, Hoelzer, Dieter, Brüggemann, Monika, Baldus, Claudia D, Dreyling, Martin, Gökbuget, Nicola

“…Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in…”
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A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia by Herold, Tobias, Jurinovic, Vindi, Batcha, Aarif M N, Bamopoulos, Stefanos A, Rothenberg-Thurley, Maja, Ksienzyk, Bianka, Hartmann, Luise, Greif, Philipp A, Phillippou-Massier, Julia, Krebs, Stefan, Blum, Helmut, Amler, Susanne, Schneider, Stephanie, Konstandin, Nikola, Sauerland, Maria Cristina, Görlich, Dennis, Berdel, Wolfgang E, Wörmann, Bernhard J, Tischer, Johanna, Subklewe, Marion, Bohlander, Stefan K, Braess, Jan, Hiddemann, Wolfgang, Metzeler, Klaus H, Mansmann, Ulrich, Spiekermann, Karsten

“…Primary therapy resistance is a major problem in acute myeloid leukemia treatment. We set out to develop a powerful and robust predictor for therapy resistance…”
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Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients by Greif, Philipp A, Hartmann, Luise, Vosberg, Sebastian, Stief, Sophie M, Mattes, Raphael, Hellmann, Ines, Metzeler, Klaus H, Herold, Tobias, Bamopoulos, Stefanos A, Kerbs, Paul, Jurinovic, Vindi, Schumacher, Daniela, Pastore, Friederike, Bräundl, Kathrin, Zellmeier, Evelyn, Ksienzyk, Bianka, Konstandin, Nikola P, Schneider, Stephanie, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Neumann, Martin, Baldus, Claudia D, Bohlander, Stefan K, Wolf, Stephan, Görlich, Dennis, Berdel, Wolfgang E, Wörmann, Bernhard J, Hiddemann, Wolfgang, Spiekermann, Karsten

“…To study mechanisms of therapy resistance and disease progression, we analyzed the evolution of cytogenetically normal acute myeloid leukemia (CN-AML) based on…”
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Molecular characterization of a second myeloid neoplasm developing after treatment for acute myeloid leukemia by Hartmann, Luise, Nadarajah, Niroshan, Meggendorfer, Manja, Höllein, Alexander, Vetro, Calogero, Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia, Stengel, Anna

“…Therapy-related myeloid neoplasms (tMN) following successful treatment of acute myeloid leukemia (AML) are rare and poorly characterized. To evaluate the…”
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Adaptive Cellular Immunity against African Swine Fever Virus Infections by Schäfer, Alexander, Franzoni, Giulia, Netherton, Christopher L, Hartmann, Luise, Blome, Sandra, Blohm, Ulrike

“…African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in…”
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Comparison of the Proteomes of Porcine Macrophages and a Stable Porcine Cell Line after Infection with African Swine Fever Virus by Wöhnke, Elisabeth, Fuchs, Walter, Hartmann, Luise, Blohm, Ulrike, Blome, Sandra, Mettenleiter, Thomas C, Karger, Axel

“…African swine fever virus (ASFV), causing an OIE-notifiable viral disease of swine, is spreading over the Eurasian continent and threatening the global pig…”
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Molecular characterization of acute myeloid leukemia patients who relapse more than 3 years after diagnosis: an exome sequencing study of 31 patients by Hartmann, Luise, Haferlach, Claudia, Meggendorfer, Manja, Nadarajah, Niroshan, Kern, Wolfgang, Haferlach, Torsten, Stengel, Anna

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ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells by Redondo Monte, Enric, Wilding, Anja, Leubolt, Georg, Kerbs, Paul, Bagnoli, Johannes W., Hartmann, Luise, Hiddemann, Wolfgang, Chen-Wichmann, Linping, Krebs, Stefan, Blum, Helmut, Cusan, Monica, Vick, Binje, Jeremias, Irmela, Enard, Wolfgang, Theurich, Sebastian, Wichmann, Christian, Greif, Philipp A.

“…ZBTB7A is frequently mutated in acute myeloid leukemia (AML) with t(8;21) translocation. However, the oncogenic collaboration between mutated ZBTB7A and the…”
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Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of WT1 alterations and high mutation load by Vosberg, Sebastian, Hartmann, Luise, Metzeler, Klaus H, Konstandin, Nikola P, Schneider, Stephanie, Varadharajan, Ashok, Hauser, Andreas, Krebs, Stefan, Blum, Helmut, Bohlander, Stefan K, Hiddemann, Wolfgang, Tischer, Johanna, Spiekermann, Karsten, Greif, Philipp A

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Clonal hematopoiesis and preleukemia—Genetics, biology, and clinical implications by Hartmann, Luise, Metzeler, Klaus H.

“…ABSTRACT Myeloid neoplasms including myelodysplastic syndromes and acute myeloid leukemia (AML) originate from hematopoietic stem cells through sequential…”
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CHIP and hips: clonal hematopoiesis is common in patients undergoing hip arthroplasty and is associated with autoimmune disease by Hecker, Judith S., Hartmann, Luise, Rivière, Jennifer, Buck, Michèle C., van der Garde, Mark, Rothenberg-Thurley, Maja, Fischer, Luise, Winter, Susann, Ksienzyk, Bianka, Ziemann, Frank, Solovey, Maria, Rauner, Martina, Tsourdi, Elena, Sockel, Katja, Schneider, Marie, Kubasch, Anne S., Nolde, Martin, Hausmann, Dominikus, Paulus, Alexander C., Lützner, Jörg, Roth, Andreas, Bassermann, Florian, Spiekermann, Karsten, Marr, Carsten, Hofbauer, Lorenz C., Platzbecker, Uwe, Metzeler, Klaus H., Götze, Katharina S.

“…Clonal hematopoiesis (CH) is an age-related condition predisposing to blood cancer and cardiovascular disease (CVD). Murine models demonstrate CH-mediated…”
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18. Tumor specific cell sorting improves sensitivity of FISH: Implications for patients with hematologic malignancies by Hartmann, Luise, Cook, Jacqueline, Lott, Loren, Perry, Jenna, Wells, Denise, Loken, Michael, Menssen, Andrew, Xu, Dongbin

“…FISH is a standard assay for the diagnostic work-up and disease monitoring of patients with hematologic malignancies, however it is less sensitive compared to…”
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Myeloid malignancies with isolated 7q deletion can be further characterized by their accompanying molecular mutations by Hartmann, Luise, Haferlach, Claudia, Meggendorfer, Manja, Kern, Wolfgang, Haferlach, Torsten, Stengel, Anna

“…Deletions in the long arm of chromosome 7 (del(7q)) are recurrent cytogenetic aberrations in myeloid neoplasms. They occur either isolated or as part of a…”
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The clinical mutatome of core binding factor leukemia by Opatz, Sabrina, Bamopoulos, Stefanos A., Metzeler, Klaus H., Herold, Tobias, Ksienzyk, Bianka, Bräundl, Kathrin, Tschuri, Sebastian, Vosberg, Sebastian, Konstandin, Nikola P., Wang, Christine, Hartmann, Luise, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Schneider, Stephanie, Thiede, Christian, Middeke, Jan Moritz, Stölzel, Friedrich, Röllig, Christoph, Schetelig, Johannes, Ehninger, Gerhard, Krämer, Alwin, Braess, Jan, Görlich, Dennis, Sauerland, Maria Cristina, Berdel, Wolfgang E., Wörmann, Bernhard J., Hiddemann, Wolfgang, Spiekermann, Karsten, Bohlander, Stefan K., Greif, Philipp A.

“…The fusion genes CBFB / MYH11 and RUNX1 / RUNX1T1 block differentiation through disruption of the core binding factor (CBF) complex and are found in 10–15% of…”
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Molecular Characterization of Acute Myeloid Leukemia (AML) Patients Who Relapse More Than 3 Years after Diagnosis: An Exome Sequencing Study of 31 Patients by Hartmann, Luise, Nadarajah, Niroshan, Meggendorfer, Manja, Stengel, Anna, Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia

“…Introduction: Relapse of AML after initial remission occurs in about 30-50% of patients (pts) and is associated with dismal outcome. The majority of pts…”
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Comprehensive molecular characterization of myeloid malignancies with 9q deletion by Hartmann, Luise, Haferlach, Torsten, Meggendorfer, Manja, Kern, Wolfgang, Haferlach, Claudia, Stengel, Anna

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Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes by Windisch, Roland, Soliman, Sarah, Hoffmann, Adrian, Chen-Wichmann, Linping, Danese, Anna, Vosberg, Sebastian, Bravo, Jimena, Lutz, Sebastian, Kellner, Christian, Fischer, Alexander, Gebhard, Claudia, Redondo Monte, Enric, Hartmann, Luise, Schneider, Stephanie, Beier, Fabian, Strobl, Carolin Dorothea, Weigert, Oliver, Peipp, Matthias, Schündeln, Michael, Stricker, Stefan H, Rehli, Michael, Bernhagen, Jürgen, Humpe, Andreas, Klump, Hannes, Brendel, Christian, Krause, Daniela S, Greif, Philipp A, Wichmann, Christian

“…Ex vivo expansion of human CD34+ hematopoietic stem and progenitor cells remains a challenge due to rapid differentiation after detachment from the bone marrow…”
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Therapy-Related Myeloid Neoplasms (tMN) Following Treatment of Acute Myeloid Leukemia (AML): Exome Sequencing Reveals the Presence of an Ancestral Clone Refractory to Chemotherapy by Hartmann, Luise, Nadarajah, Niroshan, Meggendorfer, Manja, Höllein, Alexander, Vetro, Calogero, Stengel, Anna, Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia

“…The WHO recognizes tMN as a distinct disease entity. The majority of tMN arise after treatment of solid tumors with cytotoxic chemotherapy or radiation…”
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Compartment-specific mutational landscape of clonal hematopoiesis by Hartmann, Luise, Hecker, Judith S., Rothenberg-Thurley, Maja, Rivière, Jennifer, Jentzsch, Madlen, Ksienzyk, Bianka, Buck, Michèle C., van der Garde, Mark, Fischer, Luise, Winter, Susann, Rauner, Martina, Tsourdi, Elena, Weidner, Heike, Sockel, Katja, Schneider, Marie, Kubasch, Anne S., Nolde, Martin, Hausmann, Dominikus, Lützner, Jörg, Goralski, Szymon, Bassermann, Florian, Spiekermann, Karsten, Hofbauer, Lorenz C., Schwind, Sebastian, Platzbecker, Uwe, Götze, Katharina S., Metzeler, Klaus H.

“…Clonal hematopoiesis (CH) is characterized by somatic mutations in blood cells of individuals without hematologic disease. While the mutational landscape of CH…”
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