Search Results - "HARTMAN, NEIL"

Prevalence of Cardiac Amyloidosis in Patients Referred for Transcatheter Aortic Valve Replacement by Scully, Paul R., Treibel, Thomas A., Fontana, Marianna, Lloyd, Guy, Mullen, Michael, Pugliese, Francesca, Hartman, Neil, Hawkins, Philip N., Menezes, Leon J., Moon, James C.

“…Wild-type transthyretin amyloid (wtATTR) affects the heart, causing a restrictive cardiomyopathy-deposits can be found in up to 25% of individuals >85 years of…”
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In vitro UGT1A1 inhibition by tyrosine kinase inhibitors and association with drug-induced hyperbilirubinemia by Qosa, Hisham, Avaritt, Brittany R., Hartman, Neil R., Volpe, Donna A.

“…Purpose Hyperbilirubinemia has been observed in patients treated with tyrosine kinase inhibitor (TKI) drugs. Therefore, it would be beneficial to understand…”
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Prevalence and outcome of dual aortic stenosis and cardiac amyloid pathology in patients referred for transcatheter aortic valve implantation by Scully, Paul R, Patel, Kush P, Treibel, Thomas A, Thornton, George D, Hughes, Rebecca K, Chadalavada, Sucharitha, Katsoulis, Michail, Hartman, Neil, Fontana, Marianna, Pugliese, Francesca, Sabharwal, Nikant, Newton, James D, Kelion, Andrew, Ozkor, Muhiddin, Kennon, Simon, Mullen, Michael, Lloyd, Guy, Menezes, Leon J, Hawkins, Philip N, Moon, James C

“…Abstract Aims Cardiac amyloidosis is common in elderly patients with aortic stenosis (AS) referred for transcatheter aortic valve implantation (TAVI). We…”
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Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes by Qosa, Hisham, Ribeiro, Alexandre J.S., Hartman, Neil R., Volpe, Donna A.

“…It has recently become possible to produce hepatocytes from human induced pluripotent stem cells (iPSC-heps), which may offer some advantages over primary…”
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Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation by Rubiano, Andrés, Indapurkar, Amruta, Yokosawa, Ryosuke, Miedzik, Alina, Rosenzweig, Barry, Arefin, Ayesha, Moulin, Chloe M., Dame, Keri, Hartman, Neil, Volpe, Donna A., Matta, Murali K., Hughes, David J., Strauss, David G., Kostrzewski, Tomasz, Ribeiro, Alexandre J. S.

“…Liver microphysiological systems (MPSs) are promising models for predicting hepatic drug effects. Yet, after a decade since their introduction, MPSs are not…”
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Distribution of injected technetium(99m)-labeled mesenchymal stem cells in horses with naturally occurring tendinopathy by Becerra, Patricia, Valdés Vázquez, Miguel A, Dudhia, Jayesh, Fiske-Jackson, Andrew R, Neves, Francisco, Hartman, Neil G, Smith, Roger K W

“…This study aimed to investigate immediate cell survival and distribution following different administration routes of mesenchymal stem cells (MSCs) into…”
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Human radiolabeled mass balance studies supporting the FDA approval of new drugs by Ramamoorthy, Anuradha, Bende, Girish, Chow, Edwin Chiu Yuen, Dimova, Hristina, Hartman, Neil, Jean, Daphney, Pahwa, Sonia, Ren, Yunzhao, Shukla, Chinmay, Yang, Yuching, Doddapaneni, Suresh, Danielsen, Zhixia Yan

“…Human radiolabeled mass balance studies are an important component of the clinical pharmacology programs supporting the development of new investigational…”
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In Vivo Imaging and Tracking of Technetium-99m Labeled Bone Marrow Mesenchymal Stem Cells in Equine Tendinopathy by Dudhia, Jayesh, Becerra, Patricia, Valdés, Miguel A, Neves, Francisco, Hartman, Neil G, Smith, Roger K W

“…Recent advances in the application of bone marrow mesenchymal stem cells (BMMSC) for the treatment of tendon and ligament injuries in the horse suggest…”
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More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in vitro systems by Hartman, Neil R., Mao, Jinzhe J., Zhou, Hongfei, Boyne, Michael T., Wasserman, Adam M., Taylor, Kellie, Racoosin, Judith A., Patel, Vikram, Colatsky, Thomas

“…•Benzocaine produces extensive methemoglobin when exposed to blood and liver enzymes.•Lidocaine produces no methemoglobin under the same conditions as…”
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Reaction of Geldanamycin and C17-Substituted Analogues with Glutathione:  Product Identifications and Pharmacological Implications by Cysyk, Richard L, Parker, Robert J, Barchi, Joseph J, Steeg, Patricia S, Hartman, Neil R, Strong, John M

“…17-Dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and 17-allylamino-17-demethoxygeldanamycin (17-AAG) are two derivatives of geldanamycin (GA) that…”
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Technetium-99m-Tetrofosmin as a Substrate for P-Glycoprotein: In Vitro Studies in Multidrug-Resistant Breast Tumor Cells by Ballinger, James R, Bannerman, James, Boxen, Izzie, Firby, Patricia, Hartman, Neil G, Moore, Malcolm J

“…The accumulation of 99mTc-tetrofosmin (TFos) was studied in wildtype (WT) and doxorubicin-resistant (AdrR) variants of the rat MatB and human MCF-7 breast…”
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Stability and Comparative Metabolism of Selected Felbamate Metabolites and Postulated Fluorofelbamate Metabolites by Postmitochondrial Suspensions by Parker, Robert J, Hartman, Neil R, Roecklein, Bryan A, Mortko, Henry, Kupferberg, Harvey J, Stables, James, Strong, John M

“…Evidence has been presented suggesting that a reactive metabolite, 2-phenylpropenal (ATPAL), may be responsible for the toxicities observed during therapy with…”
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Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin? by Cheow, Heok K, Ruparelia, Prina, Shankar, Sonal, Szczepura, Katherine R, Ballinger, James R, Hartman, Neil G, Chilvers, Edwin R, Peters, A Michael

“…OBJECTIVEThe clearance rate of inhaled Tc-sestamibi from the lungs of healthy nonsmoking individuals is much slower than would be expected from its physical…”
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Pulmonary elimination rate of inhaled 99mTc‐sestamibi radioaerosol is delayed in healthy cigarette smokers by Ruparelia, Prina, Cheow, Heok K., Evans, John W., Banney, Leith, Shankar, Sonal, Szczepura, Katherine R., Swift, Anna E., Ballinger, James R., Hartman, Neil G., Chilvers, Edwin R., Peters, A. Michael

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Very little is known about the physiology of P‐glycoprotein (P‐gp) expression in the lungs. • Ex vivo evidence based…”
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In vivo Activity against HIV and Favorable Toxicity Profile of 2$^{\prime}$,3$^{\prime}$-Dideoxyinosine by Yarchoan, Robert, Mitsuya, Hiroaki, Thomas, Rose V., Pluda, James M., Hartman, Neil R., Perno, Carlo-Federico, Marczyk, Kathy S., Allain, Jean-Pierre, Johns, David G., Broder, Samuel

“…The purine analog 2$^{\prime}$,3$^{\prime}$-dideoxyinosine (ddI), which has anti-retroviral activity in vitro was administered for up to 42 weeks to 26…”
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In situ β-irradiation of a brain arteriovenous malformation model by ROY, Daniel, SOUCY, Jean-Paul, HARTMAN, Neil G, JANICKI, Christian, WEILL, Alain, GUILBERT, Francois, PAPINEAU, Karl, RAYMOND, Jean

“…The treatment of large brain arteriovenous malformations (BAVMs) is challenging, and embolization alone is seldom curative. The study goal is to enhance the…”
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sup.89Zr-labelled Obinutuzumab: a potential immuno-PET radiopharmaceutical by Sarcan, Elif Tugce, Paisey, Stephen, Ruthardt, Ma, Ozer, Asuman Yekta, Marshall, Christopher, Hartman, Neil

“…Obinutuzumab (Obi) is a clinically approved a next-generation monoclonal antibody (mAb), showing specific binding to the CD20 B-cell surface markers which is a…”
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Identifying Cardiac Amyloid in Aortic Stenosis: ECV Quantification by CT in TAVR Patients by Scully, Paul R, Patel, Kush P, Saberwal, Bunny, Klotz, Ernst, Augusto, João B, Thornton, George D, Hughes, Rebecca K, Manisty, Charlotte, Lloyd, Guy, Newton, James D, Sabharwal, Nikant, Kelion, Andrew, Kennon, Simon, Ozkor, Muhiddin, Mullen, Michael, Hartman, Neil, Cavalcante, João L, Menezes, Leon J, Hawkins, Philip N, Treibel, Thomas A, Moon, James C, Pugliese, Francesca

“…The purpose of this study was to validate computed tomography measured ECV (ECV ) as part of routine evaluation for the detection of cardiac amyloid in…”
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DPD Quantification in Cardiac Amyloidosis: A Novel Imaging Biomarker by Scully, Paul R, Morris, Elizabeth, Patel, Kush P, Treibel, Thomas A, Burniston, Maria, Klotz, Ernst, Newton, James D, Sabharwal, Nikant, Kelion, Andrew, Manisty, Charlotte, Kennon, Simon, Ozkor, Muhiddin, Mullen, Michael, Hartman, Neil, Elliott, Perry M, Pugliese, Francesca, Hawkins, Philip N, Moon, James C, Menezes, Leon J

“…To assess whether single-photon emission computed tomography (SPECT/CT) quantification of bone scintigraphy would improve diagnostic accuracy and offer a means…”
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Simultaneous UHPLC-MS/MS method of estradiol metabolites to support the evaluation of Phase-2 metabolic activity of induced pluripotent stem cell derived hepatocytes by Indapurkar, Amruta, Hartman, Neil, Patel, Vikram, Matta, Murali K.

“…The goal of this study was to develop and validate a high-throughput UHPLC-MS/MS method for simultaneous quantitation of three estradiol metabolites namely…”
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