Search Results - "HARTINGER, Christian G."

Bioorganometallic chemistry--from teaching paradigms to medicinal applications by Hartinger, Christian G, Dyson, Paul J

“…In undergraduate level organometallic chemistry courses students are usually taught that organometallic compounds are toxic and unstable in air and water…”
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Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action by Bytzek, Anna K., Koellensperger, Gunda, Keppler, Bernhard K., G. Hartinger, Christian

“…The ruthenium complex sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP-1339/IT139) has entered clinical trials as the more soluble alternative to…”
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Anticancer activity of metal complexes: involvement of redox processes by Jungwirth, Ute, Kowol, Christian R, Keppler, Bernhard K, Hartinger, Christian G, Berger, Walter, Heffeter, Petra

“…Cells require tight regulation of the intracellular redox balance and consequently of reactive oxygen species for proper redox signaling and maintenance of…”
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Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs by Hartinger, Christian G, Groessl, Michael, Meier, Samuel M, Casini, Angela, Dyson, Paul J

“…Mass spectrometry (MS) has emerged as an important tool for studying anticancer metallodrugs in complex biological samples and for characterising their…”
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An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin by Meier, Samuel M., Kreutz, Dominique, Winter, Lilli, Klose, Matthias H. M., Cseh, Klaudia, Weiss, Tamara, Bileck, Andrea, Alte, Beatrix, Mader, Johanna C., Jana, Samir, Chatterjee, Annesha, Bhattacharyya, Arindam, Hejl, Michaela, Jakupec, Michael A., Heffeter, Petra, Berger, Walter, Hartinger, Christian G., Keppler, Bernhard K., Wiche, Gerhard, Gerner, Christopher

“…Organometallic metal(arene) anticancer agents require ligand exchange for their anticancer activity and this is generally believed to confer low selectivity…”
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KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients by Hartinger, Christian G., Jakupec, Michael A., Zorbas-Seifried, Stefanie, Groessl, Michael, Egger, Alexander, Berger, Walter, Zorbas, Haralabos, Dyson, Paul J., Keppler, Bernhard K.

“…The promising drug candidate indazolium trans‐[tetrachlorobis(1H‐indazole)ruthenate(III)] (KP1019) is the second Ru‐based anticancer agent to enter clinical…”
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Antitumour metal compounds: more than theme and variations by Jakupec, Michael A, Galanski, Markus, Arion, Vladimir B, Hartinger, Christian G, Keppler, Bernhard K

“…Triggered by the resounding success of cisplatin, the past decades have seen tremendous efforts to produce clinically beneficial analogues. The recent…”
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From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1 H-indazole)ruthenate(III)] (KP1019 or FFC14A) by Hartinger, Christian G., Zorbas-Seifried, Stefanie, Jakupec, Michael A., Kynast, Bernd, Zorbas, Haralabos, Keppler, Bernhard K.

“…Indazolium trans-[tetrachlorobis(1 H-indazole)ruthenate(III)] (KP1019 or FFC14A) is just the second ruthenium-based anticancer agent after NAMI-A which was…”
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Polynuclear ruthenium, osmium and gold complexes. The quest for innovative anticancer chemotherapeutics by Hartinger, Christian G, Phillips, Andrew D, Nazarov, Alexey A

“…Polynuclear compounds are a relatively new and successful approach in metal-based cancer chemotherapy as typified by the trinuclear Pt compound BBR3464 which…”
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Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds by Casini, Angela, Gabbiani, Chiara, Sorrentino, Francesca, Rigobello, Maria Pia, Bindoli, Alberto, Geldbach, Tilmann J, Marrone, Alessandro, Re, Nazzareno, Hartinger, Christian G, Dyson, Paul J, Messori, Luigi

“…A series of ruthenium(II)−arene (RAPTA) compounds were evaluated for their ability to inhibit thioredoxin reductase (either cytosolic or mitochondrial) and…”
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A Combined Spectroscopic and Protein Crystallography Study Reveals Protein Interactions of RhI(NHC) Complexes at the Molecular Level by Daubit, Isabelle M, Sullivan, Matthew P, John, Milena, Goldstone, David C, Hartinger, Christian G, Metzler-Nolte, Nils

“…While most Rh–N-heterocyclic carbene (NHC) complexes currently investigated in anticancer research contain a Rh­(III) metal center, an increasing amount of…”
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From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N‑Heterocyclic-Carbene Complexes as Anticancer Agents by Lam, Nelson Y. S, Truong, Dianna, Burmeister, Hilke, Babak, Maria V, Holtkamp, Hannah U, Movassaghi, Sanam, Ayine-Tora, Daniel Moscoh, Zafar, Ayesha, Kubanik, Mario, Oehninger, Luciano, Söhnel, Tilo, Reynisson, Jóhannes, Jamieson, Stephen M. F, Gaiddon, Christian, Ott, Ingo, Hartinger, Christian G

“…The promise of the metal­(arene) structure as an anticancer pharmacophore has prompted intensive exploration of this chemical space. While N-heterocyclic…”
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The ruthenium(II)–arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53–JNK pathways by Chatterjee, Soumya, Kundu, Subhadip, Bhattacharyya, Arindam, Hartinger, Christian G., Dyson, Paul J.

“…An investigation of the molecular mechanism of the anticancer activity demonstrated by the ruthenium(II)–arene compound [Ru(η 6 - p -cymene)Cl 2 (pta)] (pta is…”
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Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo by Sullivan, Matthew P, Adams, Muneebah, Riisom, Mie, Herbert, Caitlin D, Tong, Kelvin K H, Astin, Jonathan W, Jamieson, Stephen M F, Hanif, Muhammad, Goldstone, David C, Hartinger, Christian G

“…Pt(terpyridine) complexes are well-known DNA intercalators. The introduction of an NHC co-ligand rendered such a complex highly antiproliferative in cancer…”
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Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies by Dömötör, Orsolya, Hartinger, Christian G., Bytzek, Anna K., Kiss, Tamás, Keppler, Bernhard K., Enyedy, Eva A.

“…Indazolium trans -[tetrachloridobis(1 H -indazole)ruthenate(III)] (KP1019) and its Na + analogue (KP1339) are two of the most prominent non-platinum antitumor…”
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Impact of the Metal Center and Leaving Group on the Anticancer Activity of Organometallic Complexes of Pyridine-2-carbothioamide by Arshad, Jahanzaib, Tong, Kelvin K H, Movassaghi, Sanam, Söhnel, Tilo, Jamieson, Stephen M F, Hanif, Muhammad, Hartinger, Christian G

“…Ru (cym)Cl (cym = η - -cymene) complexes of pyridinecarbothioamides have shown potential for development as orally active anticancer metallodrugs, underlined…”
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Making organoruthenium complexes of 8-hydroxyquinolines more hydrophilic: impact of a novel l-phenylalanine-derived arene ligand on the biological activity by Movassaghi, Sanam, Hanif, Muhammad, Holtkamp, Hannah U, Söhnel, Tilo, Jamieson, Stephen M F, Hartinger, Christian G

“…Ru(arene) compounds have many desirable features making them promising candidates for further development in anticancer drug research. While a lot of emphasis…”
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Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action by Babak, Maria V, Pfaffeneder-Kmen, Martin, Meier-Menches, Samuel M, Legina, Maria S, Theiner, Sarah, Licona, Cynthia, Orvain, Christophe, Hejl, Michaela, Hanif, Muhammad, Jakupec, Michael A, Keppler, Bernhard K, Gaiddon, Christian, Hartinger, Christian G

“…Platinum-based anticancer coordination compounds are widely used in the treatment of many tumor types, where they are very effective but also cause severe side…”
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Anticancer activity of Ru- and Os(arene) compounds of a maleimide-functionalized bioactive pyridinecarbothioamide ligand by Hanif, Muhammad, Moon, Sally, Sullivan, Matthew P., Movassaghi, Sanam, Kubanik, Mario, Goldstone, David C., Söhnel, Tilo, Jamieson, Stephen M.F., Hartinger, Christian G.

“…With the aim of increasing the accumulation of Ru anticancer agents in the tumor, a targeted delivery strategy based on a maleimide anchor for the biological…”
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Influence of the Spacer Length on the in Vitro Anticancer Activity of Dinuclear Ruthenium−Arene Compounds by Mendoza-Ferri, Maria-Grazia, Hartinger, Christian G, Eichinger, Rene E, Stolyarova, Natalya, Severin, Kay, Jakupec, Michael A, Nazarov, Alexey A, Keppler, Bernhard K

“…Water-soluble dinuclear Ru−arene complexes were synthesized and found to exert promising cytotoxic effects in human cancer cells, which could be increased to…”
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