Search Results - "HARROLD, J"

Network-Based Approaches in Drug Discovery and Early Development by Harrold, J M, Ramanathan, M, Mager, D E

“…Identification of novel targets is a critical first step in the drug discovery and development process. Most diseases such as cancer, metabolic disorders, and…”
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What have human experimental overfeeding studies taught us about adipose tissue expansion and susceptibility to obesity and metabolic complications? by Cuthbertson, D J, Steele, T, Wilding, J P, Halford, J C, Harrold, J A, Hamer, M, Karpe, F

“…Overfeeding experiments, in which we impose short-term positive energy balance, help unravel the cellular, physiological and behavioural adaptations to…”
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Differences in parental feeding styles and practices and toddler eating behaviour across complementary feeding methods: Managing expectations through consideration of effect size by Komninou, S., Halford, J.C.G., Harrold, J.A.

“…Nutritional experiences during infancy and toddlerhood influence the development of healthy eating habits later in life. Interest into solid food introduction…”
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Will smaller plates lead to smaller waists? A systematic review and meta‐analysis of the effect that experimental manipulation of dishware size has on energy consumption by Robinson, E, Nolan, S, Tudur‐Smith, C, Boyland, E. J, Harrold, J. A, Hardman, C. A, Halford, J. C. G

“…It has been suggested that providing consumers with smaller dishware may prove an effective way of helping people eat less and preventing weight gain, but…”
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Environmental life cycle assessment of production of the high intensity sweetener steviol glycosides from Stevia rebaudiana leaf grown in Europe: The SWEET project by Suckling, J., Morse, S., Murphy, R., Astley, S., Halford, J. C. G., Harrold, J. A., Le-Bail, A., Koukouna, E., Musinovic, H., Perret, J., Raben, A., Roe, M., Scholten, J., Scott, C., Stamatis, C., Westbroek, C.

“…Purpose There is an increasing interest in the use of non-nutritive sweeteners to replace added sugar in food and beverage products for reasons of improving…”
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Environmental life cycle assessment of production of the non-nutritive sweetener sucralose (E955) derived from cane sugar produced in the United States of America: The SWEET project by Blenkley, E., Suckling, J., Morse, S., Murphy, R., Raats, M., Astley, S., Halford, J. C. G., Harrold, J. A., Le-Bail, A., Koukouna, E., Musinovic, H., Raben, A., Roe, M., Scholten, J., Scott, C., Westbroek, C.

“…Purpose There is increasing concern about the detrimental health effects of added sugar in food and drink products. Sweeteners are seen as a viable…”
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Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre by Ranganath, L.R., Khedr, M., Milan, A.M., Davison, A.S., Hughes, A.T., Usher, J.L., Taylor, S., Loftus, N., Daroszewska, A., West, E., Jones, A., Briggs, M., Fisher, M., McCormick, M., Judd, S., Vinjamuri, S., Griffin, R., Psarelli, E.E., Cox, T.F., Sireau, N., Dillon, J.P., Devine, J.M., Hughes, G., Harrold, J., Barton, G.J., Jarvis, J.C., Gallagher, J.A.

“…Does Nitisinone prevent the clinical progression of the Alkaptonuria? In this observational study on 39 patients, 2 mg of daily nitisinone inhibited ochronosis…”
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Effect of sildenafil on maternal hemodynamics in pregnancies complicated by severe early‐onset fetal growth restriction: planned subgroup analysis from a multicenter randomized placebo‐controlled double‐blind trial by Khalil, A., Sharp, A., Cornforth, C., Jackson, R., Mousa, H., Stock, S., Harrold, J., Turner, M. A., Kenny, L. C., Baker, P. N., Johnstone, E. D., Von Dadelszen, P., Magee, L., Papageorghiou, A. T., Alfirevic, Z.

“…ABSTRACT Objectives Fetal growth restriction (FGR) is associated with maternal cardiovascular changes. Sildenafil, a phosphodiesterase type‐5 inhibitor,…”
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Similarities and differences between men with self-reported lifelong and acquired difficulty reaching ejaculation by Rowland, David L., McNabney, Sean M., Attinger, Drew R., Harrold, Kathryn J., Kӧvi, Zsuzsanna, Hevesi, Krisztina

“…Men with delayed ejaculation are often categorized into lifelong and acquired subtypes, yet little is known about similarities and differences between these…”
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Semi-mechanistic Population Pharmacokinetic Model of Multivalent Trastuzumab Emtansine in Patients with Metastatic Breast Cancer by Chudasama, V L, Schaedeli Stark, F, Harrold, J M, Tibbitts, J, Girish, S R, Gupta, M, Frey, N, Mager, D E

“…Trastuzumab emtansine (T‐DM1) is an antibody–drug conjugate (ADC) composed of multiple molecules of the antimicrotubule agent DM1 linked to trastuzumab, a…”
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Reduction of noise in the neonatal intensive care unit using sound-activated noise meters by Wang, D, Aubertin, C, Barrowman, N, Moreau, K, Dunn, S, Harrold, J

“…To determine if sound-activated noise meters providing direct audit and visual feedback can reduce sound levels in a level 3 neonatal intensive care unit…”
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Examining the effects of a targeted noise reduction program in a neonatal intensive care unit by Wang, D, Aubertin, C, Barrowman, N, Moreau, K, Dunn, S, Harrold, J

“…To determine whether implementation of a noise reduction policy followed by the addition of direct audit and feedback reduces noise levels in a tertiary-level…”
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Therapeutic potential of targeting the endocannabinoids: implications for the treatment of obesity, metabolic syndrome, drug abuse and smoking cessation by Tucci, S A, Halford, J C G, Harrold, J A, Kirkham, T C

“…Rimonabant (SR141716, Acomplia) has been described as an antagonist/inverse agonist at the cannabinoid receptor type 1 (CB1). It has been widely used as a tool…”
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Why should hospitals fund delirium research? by Harrold, Patrick J

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Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone by Davison, A.S., Harrold, J.A., Hughes, G., Norman, B.P., Devine, J., Usher, J., Hughes, A.T., Khedr, M., Gallagher, J.A., Milan, A.M., J.C.G., Halford, Ranganath, L.R.

“…Concerns exist over hypertyrosinaemia that is observed following treatment with nitisinone. It has been suggested that tyrosine may compete with tryptophan for…”
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Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice by Harrold, J.A., Hughes, G.M., O’Shiel, K., Quinn, E., Boyland, E.J., Williams, N.J., Halford, J.C.G.

“…► A number of products in the consumer market are purported to affect appetite. ► A mixed herbal product was found to acutely reduce intake. ► The effects of…”
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Effects of olanzapine in male rats: enhanced adiposity in the absence of hyperphagia, weight gain or metabolic abnormalities by Cooper, G.D., Pickavance, L.C., Wilding, J.P.H., HarroLd, J.A., HaLford, J.C.G., Goudie, A.J.

“…Many of olanzapine's (OLZ) actions in humans related to weight regulation can be modelled in female rats (Cooper et al., 2005). Such effects include weight…”
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Coconut and sunflower oil ratios in ice cream influence subsequent food selection and intake by Rizzo, G, Masic, U, Harrold, J.A, Norton, J.E, Halford, J.C.G

“…Abstract The effect of coconut oil (CO, containing mainly medium chain triglycerides - MCTs) and sunflower oil (SO, containing mainly long chain triglycerides…”
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Stigmatization and obesity: unexpected consequences with public health relevance by Robinson, E, Boyland, E, Christiansen, P, Harrold, J, Kirkham, T

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OP19.10: Maternal cardiovascular changes secondary to sildenafil intake in pregnancies complicated by severe fetal growth restriction: STRIDER trial by Khalil, A., Sharp, A., Cornforth, C., Jackson, R., Mousa, H., Stock, S., Harrold, J., Turner, M., Kenny, L., Baker, P., Johnstone, E., Dadelszen, P., Magee, L., Papageorghiou, A.T., Alfirevic, Z.

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