Search Results - "HARRINGTON, Christina A"

RNA-Seq of human whole blood: Evaluation of globin RNA depletion on Ribo-Zero library method by Harrington, Christina A., Fei, Suzanne S., Minnier, Jessica, Carbone, Lucia, Searles, Robert, Davis, Brett A., Ogle, Kimberly, Planck, Stephen R., Rosenbaum, James T., Choi, Dongseok

“…Peripheral blood is a highly accessible biofluid providing a rich source of information about human physiology and health status. However, for studies of the…”
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RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery by Pennock, Nathan D, Jindal, Sonali, Horton, Wesley, Sun, Duanchen, Narasimhan, Jayasri, Carbone, Lucia, Fei, Suzanne S, Searles, Robert, Harrington, Christina A, Burchard, Julja, Weinmann, Sheila, Schedin, Pepper, Xia, Zheng

“…Formalin-fixed, paraffin-embedded (FFPE) tissues for RNA-seq have advantages over fresh frozen tissue including abundance and availability, connection to rich…”
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Systemic Lipopolysaccharide Protects the Brain from Ischemic Injury by Reprogramming the Response of the Brain to Stroke: A Critical Role for IRF3 by Marsh, Brenda, Stevens, Susan L, Packard, Amy E. B, Gopalan, Banu, Hunter, Brian, Leung, Philberta Y, Harrington, Christina A, Stenzel-Poore, Mary P

“…Lipopolysaccharide (LPS) preconditioning provides neuroprotection against subsequent cerebral ischemic injury through activation of its receptor, Toll-like…”
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Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes of Uveitis by Rosenbaum, James T., Harrington, Christina A., Searles, Robert P., Fei, Suzanne S., Zaki, Amr, Arepalli, Sruthi, Paley, Michael A., Hassman, Lynn M., Vitale, Albert T., Conrady, Christopher D., Keath, Puthyda, Mitchell, Claire, Watson, Lindsey, Planck, Stephen R., Martin, Tammy M., Choi, Dongseok

“…•Uveitis is a heterogeneous collection of diseases.•Despite the heterogeneity of uveitis, specific RNA transcripts expressed by cells in peripheral blood as…”
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Revising the Diagnosis of Idiopathic Uveitis by Peripheral Blood Transcriptomics by Rosenbaum, James T., Harrington, Christina A., Searles, Robert P., Fei, Suzanne S., Zaki, Amr, Arepalli, Sruthi, Paley, Michael A., Hassman, Lynn M., Vitale, Albert T., Conrady, Christopher D., Keath, Puthyda, Mitchell, Claire, Watson, Lindsey, Planck, Stephen R., Martin, Tammy M., Choi, Dongseok

“…To test the hypothesis that idiopathic uveitis can be categorized into subtypes based on gene expression from blood. Case control study. We applied RNA-Seq to…”
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Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences by Wood, Matthew D, Beadling, Carol, Neff, Tanaya, Moore, Steve, Harrington, Christina A, Baird, Lissa, Corless, Christopher

“…Diffuse gliomas are a heterogeneous category of primary central nervous system tumors. Due to their infiltrative growth precluding complete surgical resection,…”
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Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states by Stenzel-Poore, Mary P, Stevens, Susan L, Xiong, Zhigang, Lessov, Nikola S, Harrington, Christina A, Mori, Motomi, Meller, Robert, Rosenzweig, Holly L, Tobar, Eric, Shaw, Tatyana E, Chu, Xiangping, Simon, Roger P

“…Molecular mechanisms of neuroprotection that lead to ischaemic tolerance are incompletely understood. Identification of genes involved in the process would…”
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Analysis of extracellular RNA in cerebrospinal fluid by Saugstad, Julie A., Lusardi, Theresa A., Van Keuren-Jensen, Kendall R., Phillips, Jay I., Lind, Babett, Harrington, Christina A., McFarland, Trevor J., Courtright, Amanda L., Reiman, Rebecca A., Yeri, Ashish S., Kalani, M. Yashar S., Adelson, P. David, Arango, Jorge, Nolan, John P., Duggan, Erika, Messer, Karen, Akers, Johnny C., Galasko, Douglas R., Quinn, Joseph F., Carter, Bob S., Hochberg, Fred H.

“…We examined the extracellular vesicle (EV) and RNA composition of pooled normal cerebrospinal fluid (CSF) samples and CSF from five major neurological…”
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Gene expression profiling of whole blood: comparison of target preparation methods for accurate and reproducible microarray analysis by Vartanian, Kristina, Slottke, Rachel, Johnstone, Timothy, Casale, Amanda, Planck, Stephen R, Choi, Dongseok, Smith, Justine R, Rosenbaum, James T, Harrington, Christina A

“…Peripheral blood is an accessible and informative source of transcriptomal information for many human disease and pharmacogenomic studies. While there can be…”
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Novel recruitment approaches and operational results for a statewide population Cohort for cancer research: The Healthy Oregon Project by Zhang, Zhenzhen, Shafer, Autumn, Johnson-Camacho, Katie, Adey, Andrew, Anur, Pavana, Brown, Kim A, Conrad, Casey, Crist, Rachel, Farris, Paige E, Harrington, Christina A, Marriott, Lisa K, Mitchell, Asia, O'Roak, Brian, Serrato, Vanessa, Richards, C Sue, Spellman, Paul T, Shannon, Jackilen

“…Cancer health research relies on large-scale cohorts to derive generalizable results for different populations. While traditional epidemiological cohorts often…”
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AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB by Hornick, Noah I, Doron, Ben, Abdelhamed, Sherif, Huan, Jianya, Harrington, Christina A, Shen, Rongkun, Cambronne, Xiaolu A, Chakkaramakkil Verghese, Santhosh, Kurre, Peter

“…Exosomes are paracrine regulators of the tumor microenvironment and contain complex cargo. We previously reported that exosomes released from acute myeloid…”
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Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth by Garred, Michelle M, Wang, Michael M, Guo, Xin, Harrington, Christina A, Lein, Pamela J

“…Dendrites are the primary site of synapse formation in the vertebrate nervous system; however, relatively little is known about the molecular mechanisms that…”
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Randomization in laboratory procedure is key to obtaining reproducible microarray results by Yang, Hyuna, Harrington, Christina A, Vartanian, Kristina, Coldren, Christopher D, Hall, Rob, Churchill, Gary A

“…The quality of gene expression microarray data has improved dramatically since the first arrays were introduced in the late 1990s. However, the reproducibility…”
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microRNA‐130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO‐1 by Chen, Xiaowei, Zhao, Min, Huang, Jin, Li, Yuhuang, Wang, Shunqing, Harrington, Christina A., Qian, David Z., Sun, Xiao‐Xin, Dai, Mu‐Shui

“…FOSL1 is frequently overexpressed in multiple types of human cancers including invasive breast cancers and implicated in cancer invasion and metastasis…”
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MicroRNAs in Human Cerebrospinal Fluid as Biomarkers for Alzheimer's Disease by Lusardi, Theresa A, Phillips, Jay I, Wiedrick, Jack T, Harrington, Christina A, Lind, Babett, Lapidus, Jodi A, Quinn, Joseph F, Saugstad, Julie A

“…Currently available biomarkers of Alzheimer's disease (AD) include cerebrospinal fluid (CSF) protein analysis and amyloid PET imaging, each of which has…”
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Non-specific orbital inflammation: Current understanding and unmet needs by Lee, Min Joung, Planck, Stephen R., Choi, Dongseok, Harrington, Christina A., Wilson, David J., Dailey, Roger A., Ng, John D., Steele, Eric A., Hamilton, Bronwyn E., Khwarg, Sang In, Rosenbaum, James T.

“…Non-specific orbital inflammation (NSOI) is a noninfectious inflammatory condition of the orbit. Although it is generally considered the most common diagnosis…”
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High throughput sequencing in mice: a platform comparison identifies a preponderance of cryptic SNPs by Walter, Nicole A R, Bottomly, Daniel, Laderas, Ted, Mooney, Michael A, Darakjian, Priscila, Searles, Robert P, Harrington, Christina A, McWeeney, Shannon K, Hitzemann, Robert, Buck, Kari J

“…Allelic variation is the cornerstone of genetically determined differences in gene expression, gene product structure, physiology, and behavior. However,…”
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Creating a Career Path for Shared Research Resources Personnel by Fletcher, Luellen, Harrington, Christina A, Nilsen, Aaron, Petrie, Stefanie Kaech, Chitty, Andrew I

“…Shared research resources are essential to academic research. A rapidly evolving workforce within a highly competitive market is making recruitment and…”
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Validation of MicroRNA Biomarkers for Alzheimer's Disease in Human Cerebrospinal Fluid by Wiedrick, Jack T, Phillips, Jay I, Lusardi, Theresa A, McFarland, Trevor J, Lind, Babett, Sandau, Ursula S, Harrington, Christina A, Lapidus, Jodi A, Galasko, Douglas R, Quinn, Joseph F, Saugstad, Julie A

“…We previously discovered microRNAs (miRNAs) in cerebrospinal fluid (CSF) that differentiate Alzheimer's disease (AD) patients from Controls. Here we examined…”
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Tofacitinib as a Steroid-Sparing Therapy in Pulmonary Sarcoidosis, an Open-Label Prospective Proof-of-Concept Study by Friedman, Marcia A., Le, Brian, Stevens, Janelle, Desmarais, Julianna, Seifer, Daniel, Ogle, Kimberly, Choi, Dongseok, Harrington, Christina A., Jackson, Peter, Rosenbaum, James T.

“…This is a prospective, open-label, proof-of-concept study of tofacitinib, a Janus kinase inhibitor, as a steroid-sparing therapy in corticosteroid-dependent…”
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