Search Results - "HARRIES, M. H"

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia by Davis, John B, Gray, Julie, Gunthorpe, Martin J, Hatcher, Jonathan P, Davey, Phil T, Overend, Philip, Harries, Mark H, Latcham, Judi, Clapham, Colin, Atkinson, Kirsty, Hughes, Stephen A, Rance, Kim, Grau, Evelyn, Harper, Alex J, Pugh, Perdita L, Rogers, Derek C, Bingham, Sharon, Randall, Andrew, Sheardown, Steven A

“…The vanilloid receptor-1 (VR1) is a ligand-gated, non-selective cation channel expressed predominantly by sensory neurons. VR1 responds to noxious stimuli…”
Get full text

Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology by Jerman, J C, Brough, S J, Prinjha, R, Harries, M H, Davis, J B, Smart, D

“…The vanilloid receptor (VR1) is a ligand‐gated ion channel, which plays an important role in nociceptive processing. Therefore, a pharmacological…”
Get full text

Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat by Woolley, M. L., Waters, K. A., Gartlon, J. E., Lacroix, L. P., Jennings, C., Shaughnessy, F., Ong, A., Pemberton, D. J., Harries, M. H., Southam, E., Jones, D. N. C., Dawson, L. A.

“…Rationale Positive allosteric modulators of the glutamatergic α-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid (AMPA) receptor do not stimulate AMPA…”
Get full text

The use of genomics technology to investigate gene expression changes in cultured human liver cells by Harries, H.M, Fletcher, S.T, Duggan, C.M, Baker, V.A

“…The field of genomics has great potential in toxicology; however, the technology is still in its infancy and there are many questions that need to be…”
Get full text

SB-334867-A antagonises orexin mediated excitation in the locus coeruleus by Soffin, E.M., Evans, M.L., Gill, C.H., Harries, M.H., Benham, C.D., Davies, C.H.

“…Electrophysiological recordings from identified noradrenergic locus coeruleus (LC) neurones in rat brain slices have revealed that the orexins can cause direct…”
Get full text

Frameworks of analysis for the neural representation of animate objects and actions by PERRETT, D. I, HARRIES, M. H, BEVAN, R, THOMAS, S, BENSON, P. J, MISTLIN, A. J, CHITTY, A. J, HIETANEN, J. K, ORTEGA, J. E

“…A variety of cell types exist in the temporal cortex providing high-level visual descriptions of bodies and their movements. We have investigated the…”
Get full text

Viewer-centred and object-centred coding of heads in the macaque temporal cortex by PERRETT, D. I, ORAM, M. W, HARRIES, M. H, BEVAN, R, HIETANAN, J. K, BENSON, P. J, THOMAS, S

“…An investigation was made into the sensitivity of cells in the macaque superior temporal sulcus (STS) to the sight of different perspective views of the head…”
Get full text

SB‐272183, a selective 5‐HT1A, 5‐HT1B and 5‐HT1D receptor antagonist in native tissue by Watson, J, Roberts, C, Scott, C, Kendall, I, Collin, L, Day, N C, Harries, M H, Soffin, E, Davies, C H, Randall, A D, Heightman, T, Gaster, L, Wyman, P, Parker, C, Price, G W, Middlemiss, D N

“…A novel compound, SB‐272183 (5‐Chloro‐2, 3‐dihydro‐6‐[4‐methylpiperazin‐1‐yl]‐1[4‐pyridin‐4‐yl]napth‐1‐ylaminocarbonyl]‐1H‐indole), has been shown to have high…”
Get full text

Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1) by Gunthorpe, Martin J., Harries, Mark H., Prinjha, Rab K., Davis, John B., Randall, Andrew

“…Whole-cell voltage-clamp techniques were used to investigate the capsaicin-, voltage- and time-dependent properties of the rat vanilloid receptor (rVR1) stably…”
Get full text

The profile of sabcomeline (SB‐202026), a functionally selective M1 receptor partial agonist, in the marmoset by Harries, M H, Samson, N A, Cilia, J, Hunter, A J

“…Sabcomeline (SB‐202026, 0.03 mg kg−1, p.o.), a potent and functionally selective M1 receptor partial agonist, caused a statistically significant improvement in…”
Get full text

SB 201823-A antagonizes calcium currents in central neurons and reduces the effects of focal ischemia in rats and mice by Barone, F C, Lysko, P G, Price, W J, Feuerstein, G, al-Baracanji, K A, Benham, C D, Harrison, D C, Harries, M H, Bailey, S J, Hunter, A J

“…Excessive calcium entry into depolarized neurons contributes significantly to cerebral tissue damage after ischemia. We evaluated the ability of a novel…”
Get full text

The profile of sabcomeline (SB‐202026), a functionally selective M 1 receptor partial agonist, in the marmoset by Harries, M H, Samson, N A, Cilia, J, Hunter, A J

“…Sabcomeline (SB‐202026, 0.03 mg kg −1 , p.o.), a potent and functionally selective M 1 receptor partial agonist, caused a statistically significant improvement…”
Get full text

Rank-order inhibition by ω-conotoxins in human and animal autonomic nerve preparations by Sanger, Gareth J, Ellis, Elizabeth S, Harries, Mark H, Tilford, Nick S, Wardle, Kay A, Benham, Christopher D

“…The inhibitory effects of the ω-conotoxins GVIA, MVIIA and MVIIC on electrically-evoked, tetrodotoxin (10 −7 M)-sensitive, autonomic nerve activity were…”
Get full text

Use of preferential inspection to define the viewing sphere and characteristic views of an arbitrary machined tool part by Perrett, D I, Harries, M H, Looker, S

“…Measurements were made of the way human subjects visually inspected an idealized machined tool part (a 'widget') while learning the three-dimensional shape of…”
Get more information

Effect of SB‐205384 on the decay of GABA‐activated chloride currents in granule cells cultured from rat cerebellum by Meadows, H J, Harries, M H, Thompson, M, Benham, C D

“…4‐Amino‐7‐hydroxy‐2‐methyl‐5,6,7,8,‐tetrahydrobenzo[b]thieno[2,3‐b]pyridine‐3‐carboxylic acid, but‐2‐ynyl ester (SB‐205384) and other γ‐aminobutyric acidA…”
Get full text

Preferential inspection of views of 3-D model heads by Harries, M H, Perrett, D I, Lavender, A

“…The importance of different perspective views for the recognition of model heads was studied. In experiment 1 subjects were instructed to learn the appearance…”
Get more information

The effects of SB 206284A, a novel neuronal calcium-channel antagonist, in models of cerebral ischemia by Wood, N I, Barone, F C, Benham, C D, Brown, T H, Campbell, C A, Cooper, D G, Evans, M L, Feuerstein, G Z, Hamilton, T C, Harries, M H, King, P D, Meakin, J E, Murkitt, K L, Patel, S R, Price, W J, Roberts, J C, Rothaul, A L, Samson, N A, Smith, S J, Hunter, A J

“…The effects of SB 206284A, 1-[7-(4-benzyloxyphenoxy)heptyl] piperidine hydrochloride, have been investigated in vitro on calcium and sodium currents in…”
Get more information

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1 by Hayes, Philip, Meadows, Helen J, Gunthorpe, Martin J, Harries, Mark H, Duckworth, D.Malcolm, Cairns, William, Harrison, David C, Clarke, Catherine E, Ellington, Kathryn, Prinjha, Rab K, Barton, Amanda J.L, Medhurst, Andrew D, Smith, Graham D, Topp, Simon, Murdock, Paul, Sanger, Gareth J, Terrett, John, Jenkins, Owen, Benham, Christopher D, Randall, Andrew D, Gloger, Isro S, Davis, John B

“…Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by…”
Get full text

Characteristic views and the visual inspection of simple faceted and smooth objects: 'tetrahedra and potatoes' by Perrett, D I, Harries, M H

“…The way in which human subjects distribute their time when attempting to learn the surface appearance of objects placed on a stand free to rotate about its…”
Get more information

Complex interactions between mGluR1 and mGluR5 shape neuronal network activity in the rat hippocampus by Lanneau, Christophe, Harries, Mark H, Ray, Alison M, Cobb, Stuart R, Randall, Andrew, Davies, Ceri H

“…Group I metabotropic glutamate receptors (mGluRs) cause increased neuronal excitability that can lead to epileptogenesis and neurodegeneration. Here we have…”
Get full text