Search Results - "HARPF, Alice"

Molecular mechanisms of anthracycline cardiovascular toxicity by Narezkina, Anna, Narayan, Hari K, Zemljic-Harpf, Alice E

“…Anthracyclines are effective chemotherapeutic agents, commonly used in the treatment of a variety of hematologic malignancies and solid tumors. However, their…”
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E-cigarette aerosol impairs male mouse skeletal muscle force development and prevents recovery from injury by Nogueira, Leonardo, Zemljic-Harpf, Alice E, Yusufi, Raihana, Ranjbar, Maryam, Susanto, Christopher, Tang, Kechun, Mahata, Sushil K, Jennings, Patricia A, Breen, Ellen C

“…To date, there has been a lag between the rise in E-cigarette use and an understanding of the long-term health effects. Inhalation of E-cigarette aerosol…”
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Metabolomic analysis of serum and myocardium in compensated heart failure after myocardial infarction by McKirnan, M. Dan, Ichikawa, Yasuhiro, Zhang, Zheng, Zemljic-Harpf, Alice E., Fan, Sili, Barupal, Dinesh Kumar, Patel, Hemal H., Hammond, H. Kirk, Roth, David M.

“…To determine the metabolic adaptations to compensated heart failure using a reproducible model of myocardial infarction and an unbiased metabolic screen. To…”
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Morphine induces physiological, structural, and molecular benefits in the diabetic myocardium by Zemljic‐Harpf, Alice E., See Hoe, Louise E., Schilling, Jan M., Zuniga‐Hertz, Juan P., Nguyen, Alexander, Vaishnav, Yash J., Belza, Gianna J., Budiono, Boris P., Patel, Piyush M., Head, Brian P., Dillmann, Wolfgang H., Mahata, Sushil K., Peart, Jason N., Roth, David M., Headrick, John P., Patel, Hemal H.

“…The obesity epidemic has increased type II diabetes mellitus (T2DM) across developed countries. Cardiac T2DM risks include ischemic heart disease, heart…”
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Sustained Exposure to the SGLT2 Inhibitor Ertugliflozin, But Not NHE-1 Inhibition By Cariporide, Attenuates Adrenergic Stimulation of Cytosolic CA 2+ Levels in Spontaneously Contracting Cardiac Myocytes by Alam, Sifat M, Gierden, Kyle J, Zhao, Tengteng, Lu, Sun S, Dixit, Mihir, Babicheva, Aleksandra, Yuan, Jason, Vallon, Volker, Zemljic-Harpf, Alice E

“…Inhibitors of sodium-glucose cotransporter 2 (SGLT2i) target renal SGLT2 to reduce reabsorption of glucose, facilitate urinary glucose excretion, and lower…”
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Neuron‐specific caveolin‐1 overexpression improves motor function and preserves memory in mice subjected to brain trauma by Egawa, Junji, Schilling, Jan M., Cui, Weihua, Posadas, Edmund, Sawada, Atsushi, Alas, Basheer, Zemljic‐Harpf, Alice E., Fannon‐Pavlich, McKenzie J., Mandyam, Chitra D., Roth, David M., Patel, Hemal H., Patel, Piyush M., Head, Brian P.

“…ABSTRACT Studies in vitro and in vivo demonstrate that membrane/lipid rafts and caveolin (Cav) organize progrowth receptors, and, when overexpressed…”
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Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes by Zemljic-Harpf, Alice E, Godoy, Joseph C, Platoshyn, Oleksandr, Asfaw, Elizabeth K, Busija, Anna R, Domenighetti, Andrea A, Ross, Robert S

“…Vinculin (Vcl) links actin filaments to integrin- and cadherin-based cellular junctions. Zonula occludens-1 (ZO-1, also known as TJP1) binds connexin-43 (Cx43,…”
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Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes by Godoy, Joseph C., Niesman, Ingrid R., Busija, Anna R., Kassan, Adam, Schilling, Jan M., Schwarz, Anna, Alvarez, Erika A., Dalton, Nancy D., Drummond, John C., Roth, David M., Kararigas, Georgios, Patel, Hemal H., Zemljic-Harpf, Alice E.

“…ABSTRACT Statins, which reduce LDL‐cholesterol by inhibition of 3‐hydroxy‐3‐methylglutaryl–coenzyme A reductase, are among the most widely prescribed drugs…”
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Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits by Ichikawa, Yasuhiro, Zemljic-Harpf, Alice E, Zhang, Zheng, McKirnan, M Dan, Manso, Ana Maria, Ross, Robert S, Hammond, H Kirk, Patel, Hemal H, Roth, David M

“…Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an…”
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Correction to: Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking by Takashima, Yoshio, Fannon, McKenzie J., Galinato, Melissa H., Steiner, Noah L., An, Michelle, Zemljic‑Harpf, Alice E., Somkuwar, Sucharita S., Head, Brian P., Mandyam, Chitra D.

“…The author reports that data for electrophysiology findings reported in Figs. 4 and 5 for control group and Meth Rst group have been published previously…”
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Statin Use in Relation to COVID-19 and Other Respiratory Infections: Muscle and Other Considerations by Golomb, Beatrice A, Han, Jun Hee, Langsjoen, Peter H, Dinkeloo, Eero, Zemljic-Harpf, Alice E

“…Statins have been widely advocated for use in COVID-19 based on large favorable observational associations buttressed by theoretical expected benefits…”
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Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy by Kim, So Yeon, Kim, Kang Ho, Schilling, Jan M, Leem, Joseph, Dhanani, Mehul, Head, Brian P, Roth, David M, Zemljic-Harpf, Alice E, Patel, Hemal H

“…Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized by blunted cardiac contractile responses to stress and/or heart…”
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Helium-Induced Changes in Circulating Caveolin in Mice Suggest a Novel Mechanism of Cardiac Protection by Weber, Nina C, Schilling, Jan M, Warmbrunn, Moritz V, Dhanani, Mehul, Kerindongo, Raphaela, Siamwala, Jamila, Song, Young, Zemljic-Harpf, Alice E, Fannon, McKenzie J, Hollmann, Markus W, Preckel, Benedikt, Roth, David M, Patel, Hemal H

“…The noble gas helium (He) induces cardioprotection in vivo through unknown molecular mechanisms. He can interact with and modify cellular membranes. Caveolae…”
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Cardiac-Myocyte-Specific Excision of the Vinculin Gene Disrupts Cellular Junctions, Causing Sudden Death or Dilated Cardiomyopathy by Zemljic-Harpf, Alice E., Miller, Joel C., Henderson, Scott A., Wright, Adam T., Manso, Ana Maria, Elsherif, Laila, Dalton, Nancy D., Thor, Andrea K., Perkins, Guy A., McCulloch, Andrew D., Ross, Robert S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking by Takashima, Yoshio, Fannon, McKenzie J., Galinato, Melissa H., Steiner, Noah L., An, Michelle, Zemljic-Harpf, Alice E., Somkuwar, Sucharita S., Head, Brian P., Mandyam, Chitra D.

“…Abstinence from unregulated methamphetamine self-administration increases hippocampal dependent, context-driven reinstatement of methamphetamine seeking. The…”
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Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth by Thievessen, Ingo, Thompson, Peter M, Berlemont, Sylvain, Plevock, Karen M, Plotnikov, Sergey V, Zemljic-Harpf, Alice, Ross, Robert S, Davidson, Michael W, Danuser, Gaudenz, Campbell, Sharon L, Waterman, Clare M

“…In migrating cells, integrin-based focal adhesions (FAs) assemble in protruding lamellipodia in association with rapid filamentous actin (F-actin) assembly and…”
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Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry by Schilling, Jan M., Cui, Weihua, Godoy, Joseph C., Risbrough, Victoria B., Niesman, Ingrid R., Roth, David M., Patel, Piyush M., Drummond, John C., Patel, Hemal H., Zemljic-Harpf, Alice E., Head, Brian P.

“…•We present a mouse model of a 7 months treatment with atorvastatin.•Atorvastatin treatment resulted in behavioral and cognitive alterations.•Syntaxin-1α and…”
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Cardiac Myocyte-Specific Excision of the β1 Integrin Gene Results in Myocardial Fibrosis and Cardiac Failure by Shai, Shaw-Yung, Harpf, Alice E, Babbitt, Christopher J, Jordan, Maria C, Fishbein, Michael C, Chen, Ju, Omura, Michelle, Leil, Tarek A, Becker, K David, Jiang, Meisheng, Smith, Desmond J, Cherry, Simon R, Loftus, Joseph C, Ross, Robert S

“…Integrins link the extracellular matrix to the cellular cytoskeleton and serve important roles in cell growth, differentiation, migration, and survival…”
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Electrophysiology and metabolism of caveolin-3-overexpressing mice by Schilling, Jan M., Horikawa, Yousuke T., Zemljic-Harpf, Alice E., Vincent, Kevin P., Tyan, Leonid, Yu, Judith K., McCulloch, Andrew D., Balijepalli, Ravi C., Patel, Hemal H., Roth, David M.

“…Caveolin-3 (Cav-3) plays a critical role in organizing signaling molecules and ion channels involved in cardiac conduction and metabolism. Mutations in Cav-3…”
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Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI by Chuang, Joyce S., Zemljic-Harpf, Alice, Ross, Robert S., Frank, Lawrence R., McCulloch, Andrew D., Omens, Jeffrey H.

“…A model‐based method for calculating three‐dimensional (3D) cardiac wall strain distributions in the mouse has been developed and tested in a genetically…”
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