Search Results - "HARPER, J."

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy by An, Heeseon, Harper, J. Wade

“…Ribosomes are abundant cellular machines 1 , 2 that are regulated by assembly, supernumerary subunit turnover and nascent chain quality control mechanisms 1 –…”
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Building and decoding ubiquitin chains for mitophagy by Harper, J. Wade, Ordureau, Alban, Heo, Jin-Mi

“…Key Points The serine/threonine-protein kinase PINK1, mitochondrial and the E3 ubiquitin-protein ligase parkin form a signal transduction pathway that marks…”
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Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation by Münch, Christian, Harper, J. Wade

“…Acute protein folding stress in the mitochondrial matrix activates both increased chaperone availability within the matrix and reduced matrix-localized protein…”
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Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways by Schulman, Brenda A, Wade Harper, J

“…The attachment of ubiquitin-like proteins (UBLs) to proteins is a central mechanism of modulation of protein function. Enzymatic, structural and genetic…”
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The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy by Heo, Jin-Mi, Ordureau, Alban, Paulo, Joao A., Rinehart, Jesse, Harper, J. Wade

“…Damaged mitochondria are detrimental to cellular homeostasis. One mechanism for removal of damaged mitochondria involves the PINK1-PARKIN pathway, which…”
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SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway by Gu, Xin, Orozco, Jose M., Saxton, Robert A., Condon, Kendall J., Liu, Grace Y., Krawczyk, Patrycja A., Scaria, Sonia M., Harper, J. Wade, Gygi, Steven P., Sabatini, David M.

“…mTOR complex 1 (mTORC1) regulates cell growth and metabolism in response to multiple environmental cues. Nutrients signal via the Rag guanosine triphosphatases…”
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High-Intensity Acceleration and Deceleration Demands in Elite Team Sports Competitive Match Play: A Systematic Review and Meta-Analysis of Observational Studies by Harper, Damian J., Carling, Christopher, Kiely, John

“…Background The external movement loads imposed on players during competitive team sports are commonly measured using global positioning system devices…”
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Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis by Harper, J. Wade, Schulman, Brenda A

“…Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad biological processes through target-specific ubiquitylation. Our…”
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Quantifying Ubiquitin Signaling by Ordureau, Alban, Münch, Christian, Harper, J. Wade

“…Ubiquitin (UB)-driven signaling systems permeate biology, and are often integrated with other types of post-translational modifications (PTMs), including…”
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Ribosome Abundance Control Via the Ubiquitin–Proteasome System and Autophagy by An, Heeseon, Harper, J. Wade

“…Ribosomes are central to the life of a cell, as they translate the genetic code into the amino acid language of proteins. Moreover, ribosomal abundance within…”
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The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase by McKenna, Michael J, Sim, Sue Im, Ordureau, Alban, Wei, Lianjie, Harper, J Wade, Shao, Sichen, Park, Eunyong

“…Organelle identity depends on protein composition. How mistargeted proteins are selectively recognized and removed from organelles is incompletely understood…”
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Proteome complexity and the forces that drive proteome imbalance by Harper, J. Wade, Bennett, Eric J.

“…The cellular proteome is a complex microcosm of structural and regulatory networks that requires continuous surveillance and modification to meet the dynamic…”
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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy by Mancias, Joseph D., Wang, Xiaoxu, Gygi, Steven P., Harper, J. Wade, Kimmelman, Alec C.

“…Through a quantitative proteomics analysis, a cohort of proteins is identified that associate with autophagosomes, among them a new cargo receptor called NCOA4…”
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A glycine-specific N-degron pathway mediates the quality control of protein N -myristoylation by Timms, Richard T, Zhang, Zhiqian, Rhee, David Y, Harper, J Wade, Koren, Itay, Elledge, Stephen J

“…The N-terminal residue influences protein stability through N-degron pathways. We used stability profiling of the human N-terminome to uncover multiple…”
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Increasing water-use efficiency directly through genetic manipulation of stomatal density by Franks, Peter J, W Doheny-Adams, Timothy, Britton-Harper, Zoe J, Gray, Julie E

“…Improvement in crop water-use efficiency (WUE) is a critical priority for regions facing increased drought or diminished groundwater resources. Despite new…”
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Defining human ERAD networks through an integrative mapping strategy by Christianson, John C., Olzmann, James A., Shaler, Thomas A., Sowa, Mathew E., Bennett, Eric J., Richter, Caleb M., Tyler, Ryan E., Greenblatt, Ethan J., Wade Harper, J., Kopito, Ron R.

“…Proteins that fail to correctly fold or assemble into oligomeric complexes in the endoplasmic reticulum (ER) are degraded by a ubiquitin- and…”
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Architecture of the human interactome defines protein communities and disease networks by Huttlin, Edward L., Bruckner, Raphael J., Paulo, Joao A., Cannon, Joe R., Ting, Lily, Baltier, Kurt, Colby, Greg, Gebreab, Fana, Gygi, Melanie P., Parzen, Hannah, Szpyt, John, Tam, Stanley, Zarraga, Gabriela, Pontano-Vaites, Laura, Swarup, Sharan, White, Anne E., Schweppe, Devin K., Rad, Ramin, Erickson, Brian K., Obar, Robert A., Guruharsha, K. G., Li, Kejie, Artavanis-Tsakonas, Spyros, Gygi, Steven P., Harper, J. Wade

“…Affinity purification–mass spectrometry elucidates protein interaction networks and co-complexes to build, to our knowledge, the largest experimentally derived…”
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Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy by Goodall, Ellen A., Kraus, Felix, Harper, J. Wade

“…Selective autophagy specifically eliminates damaged or superfluous organelles, maintaining cellular health. In this process, a double membrane structure termed…”
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Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P by Dong, Rui, Saheki, Yasunori, Swarup, Sharan, Lucast, Louise, Harper, J. Wade, De Camilli, Pietro

“…VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-anchored protein that helps generate tethers between the ER and other membranes…”
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TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress by An, Heeseon, Ordureau, Alban, Paulo, Joao A., Shoemaker, Christopher J., Denic, Vladimir, Harper, J. Wade

“…Cells respond to nutrient stress by trafficking cytosolic contents to lysosomes for degradation via macroautophagy. The endoplasmic reticulum (ER) serves as an…”
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