Search Results - "HAROOTUNIAN, A"

Photochemically generated cytosolic calcium pulses and their detection by fluo-3 by Kao, J P Y, Harootunian, A T, Tsien, R Y

“…Fluo-3, one member of a family of new fluorescent Ca2+ indicators excitable at wavelengths in the visible (Minta, A., Kao, J. P. Y., and Tsien, R. Y. (1989) J…”
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Fluorescence ratio imaging of cytosolic free Na+ in individual fibroblasts and lymphocytes by Harootunian, A T, Kao, J P, Eckert, B K, Tsien, R Y

“…New fluorescent Na+ indicators, SBFI (short for sodium-binding benzofuran isophthalate) and SBFP (short for sodium-binding benzofuran phthalate) (Minta, A.,…”
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Fluorescence ratio imaging of cyclic AMP in single cells by Adams, Stephen R, Harootunian, Alec T, Buechler, Ying Ji, Taylor, Susan S, Tsien, Roger Y

“…Fluorescence imaging is perhaps the most powerful technique currently available for continuously observing the dynamic intracellular biochemistry of single…”
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Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A by HAGIWARA, M, BRINDLE, P, HAROOTONIAN, A, ARMSTRONG, R, RIVIER, J, VALE, W, TSIEN, R, MONTMINY, M. R

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Generation of calcium oscillations in fibroblasts by positive feedback between calcium and IP3 by HAROOTUNIAN, A. T, KAO, J. P. Y, PARANJAPE, S, TSIEN, R. Y

“…A wide variety of nonexcitable cells generate repetitive transient increases in cytosolic calcium ion concentration ([Ca2+]i) when stimulated with agonists…”
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Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion by HAROOTUNIAN, A. T, ADAMS, S. R, WEI WEN, MEINKOTH, J. L, TAYLOR, S. S, TSIEN, R. Y

“…The catalytic (C) subunit of cyclic AMP (cAMP) dependent protein kinase (PKA) has previously been shown to enter and exit the nucleus of cells when…”
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Super-resolution fluorescence near-field scanning optical microscopy by HAROOTUNIAN, A, BETZIG, E, ISAACSON, M, LEWIS, A

“…A one-dimensional near-field scanning optical microscope (NSOM) operating in the fluorescence mode has been demonstrated. NSOM line scans of both metallic…”
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Practical design criteria for a dynamic ratio imaging system by Tsien, R Y, Harootunian, A T

“…Problems encountered and solutions devised during the construction of a productive Ca2(+)-imaging system are discussed. Many of these relate to the rapid and…”
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Near Field Scanning Optical Microscopy (NSOM): Development and Biophysical Applications by Betzig, E, Lewis, A, Harootunian, A, Isaacson, M, Kratschmer, E

“…A new method for high-resolution imaging, near-field scanning optical microscopy (NSOM), has been developed. The concepts governing this method are discussed,…”
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Acetoxymethyl esters of phosphates, enhancement of the permeability and potency of cAMP by SCHULTZ, C, MANA VAJANAPHANICH, HAROOTUNIAN, A. T, SAMMAK, P. J, BARRETT, K. E, TSIEN, R. Y

“…Acetoxymethyl esters of alkyl or aryl phosphates can be prepared by reacting their trialkylammonium or silver salts with acetoxymethyl bromide. Because…”
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Mediation of Growth Factor Induced DNA Synthesis and Calcium Mobilization by Gq and Gi2 by LaMorte, V. J., Harootunian, A. T., Spiegel, A. M., Tsien, R. Y., Feramisco, J. R.

“…A newly identified subclass of the heterotrimeric GTP binding regulatory protein family, Gq, has been found to be expressed in a diverse range of cell types…”
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Intracellular Cyclic AMP, Not Calcium, Determines the Direction of Vesicle Movement in Melanophores: Direct Measurement by Fluorescence Ratio Imaging by Sammak, Paul J., Adams, Stephen R., Harootunian, Alec T., Schliwa, Manfred, Tsien, Roger Y.

“…Intracellular movement of vesiculated pigment granules in angelfish melanophores is regulated by a signalling pathway that triggers kinesin and dynein-like…”
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Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal by Wen, W, Harootunian, A T, Adams, S R, Feramisco, J, Tsien, R Y, Meinkoth, J L, Taylor, S S

“…The heat-stable inhibitor of cAMP-dependent protein kinase (PKI) was shown previously to export the kinase catalytic subunit (C) from the nucleus (Fantozzi, D…”
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A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells by LAMORTE, V. J, KENNEDY, E. D, COLLINS, L. R, GOLDSTEIN, D, HAROOTUNIAN, A. T, BROWN, J. H, FERAMISCO, J. R

“…Thrombin stimulation of 1321N1 astrocytoma cells results in polyphosphoinositide hydrolysis, Ca2+ mobilization, AP-1-mediated transcriptional activation, and…”
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Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus by Fantozzi, D A, Harootunian, A T, Wen, W, Taylor, S S, Feramisco, J R, Tsien, R Y, Meinkoth, J L

“…The catalytic (C) subunit of cAMP-dependent protein kinase is inhibited by the regulatory (R) subunit and by a thermostable inhibitor (PKI). Both inhibitors…”
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Abstract PD3-02: Intraoperative tumor detection using a ratiometric activatable fluorescent peptide: A first-in-human phase I study allows tumors to be visualized in the operating room by Unkart, JT, Chen, SL, González, JE, Harootunian, A, Wallace, AM

“…Abstract Background: A continuing challenge in breast cancer surgery is the difficulty with intraoperative lymph node status determination and achieving…”
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Abstract P2-14-07: Use of an activatable cell penetrating peptide-fluorescent imaging agent (AVB-620) to identify positive and close margins intraoperatively by Chen, SL, Baron, PL, Lee, MC, Feldman, SM, McLaughlin, SA, Terando, AM, Harootunian, A, Poonka, P, Gonzalez, JE

“…Abstract Background: Intra-operative identification of positive margins and lymph nodes continues to be a challenge for breast cancer surgeons. Current…”
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VIP modulates neuronal nicotinic acetylcholine receptor function by a cyclic AMP-dependent mechanism by Gurantz, D, Harootunian, AT, Tsien, RY, Dionne, VE, Margiotta, JF

“…Neuronal nicotinic ACh receptors (AChRs) mediate synaptic transmission throughout the nervous system, and are regulated by cellular processes and interactions…”
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Mediation of growth factor induced DNA synthesis and calcium mobilization by G(q) and G(i2) by LaMorte, V J, Harootunian, A T, Spiegel, A M, Tsien, R Y, Feramisco, J R

“…The potential role of the protein Gq in growth factor signal transduction pathways and its potential relationship to the function of other G alpha subclasses…”
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Modulation by albumin of neuronal cholinergic sensitivity by Gurantz, D, Margiotta, J F, Harootunian, A T, Dionne, V E

“…Bovine serum albumin greatly enhanced the cholinergic response mediated by neuronal nicotinic acetylcholine receptors in chick ciliary ganglion neurons. The…”
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