Search Results - "HARMSEN, Martin C"

Chronic lung diseases: entangled in extracellular matrix by Burgess, Janette K, Harmsen, Martin C

“…The extracellular matrix (ECM) is the scaffold that provides structure and support to all organs, including the lung; however, it is also much more than this…”
Get full text

Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress by Moonen, Jan-Renier A J, Lee, Ee Soo, Schmidt, Marc, Maleszewska, Monika, Koerts, Jasper A, Brouwer, Linda A, van Kooten, Theo G, van Luyn, Marja J A, Zeebregts, Clark J, Krenning, Guido, Harmsen, Martin C

“…Neointimal hyperplasia is a common feature of fibro-proliferative vascular disease and characterizes initial stages of atherosclerosis. Neointimal lesions…”
Get full text

Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions by Mossel, Dieuwertje M, Moganti, Kondaiah, Riabov, Vladimir, Weiss, Christel, Kopf, Stefan, Cordero, Julio, Dobreva, Gergana, Rots, Marianne G, Klüter, Harald, Harmsen, Martin C, Kzhyshkowska, Julia

“…The number of diabetic patients in Europe and world-wide is growing. Diabetes confers a 2-fold higher risk for vascular disease. Lack of insulin production…”
Get full text

Therapeutic Prospect of Adipose-Derived Stromal Cells for the Treatment of Abdominal Aortic Aneurysm by Parvizi, Mojtaba, Harmsen, Martin C

“…Aneurysm refers to the dilation of the vessel wall for more than 50%. Abdominal aortic aneurysm (AAA) refers to the dilation and weakening of all three layers…”
Get more information

Macrophage Depletion Impairs Wound Healing and Increases Left Ventricular Remodeling after Myocardial Injury in Mice by van Amerongen, Machteld J, Harmsen, Martin C, van Rooijen, Nico, Petersen, Arjen H, van Luyn, Marja J.A

“…Macrophages have been suggested to be beneficial for myocardial wound healing. We investigated the role of macrophages in myocardial wound healing by…”
Get full text

Adipose tissue-derived ECM hydrogels and their use as 3D culture scaffold by Getova, Vasilena E., van Dongen, Joris A., Brouwer, Linda A., Harmsen, Martin C.

“…Adipose tissue has the therapeutic capacity in the form of a fat graft, for example, for treatment of irradiation-induced scars and difficult to heal dermal…”
Get full text

The fractionation of adipose tissue procedure to obtain stromal vascular fractions for regenerative purposes by van Dongen, Joris A., Stevens, Hieronymus P., Parvizi, Mojtaba, van der Lei, Berend, Harmsen, Martin C.

“…Autologous adipose tissue transplantation is clinically used to reduce dermal scarring and to restore volume loss. The therapeutic benefit on tissue damage…”
Get full text

Directional topography gradients drive optimum alignment and differentiation of human myoblasts by Almonacid Suarez, Ana Maria, Zhou, Qihui, Rijn, Patrick, Harmsen, Martin C.

“…Tissue engineering of skeletal muscle aims to replicate the parallel alignment of myotubes on the native tissue. Directional topography gradients allow the…”
Get full text

Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1 by Lee, Ee Soo, Boldo, Llorenç Solé, Fernandez, Bernadette O., Feelisch, Martin, Harmsen, Martin C.

“…Endothelial dysfunction is characterised by aberrant redox signalling and an inflammatory phenotype. Shear stress antagonises endothelial dysfunction by…”
Get full text

Endothelial progenitor cell-based neovascularization: implications for therapy by Krenning, Guido, van Luyn, Marja J.A, Harmsen, Martin C

“…Ischemic cardiovascular events are a major cause of death globally. Endothelial progenitor cell (EPC)-based approaches can result in improvement of vascular…”
Get full text

H3K27Me3 abundance increases fibrogenesis during endothelial-to-mesenchymal transition via the silencing of microRNA-29c by Fledderus, Jolien, Brouwer, Linda, Kuiper, Timara, Harmsen, Martin C, Krenning, Guido

“…Endothelial-to-mesenchymal transition (EndMT) is a transdifferentiation process in which endothelial cells (ECs) adopt a mesenchymal-like phenotype. Over the…”
Get full text

Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls by Kruk, Dennis, Yeung, Anna C Y, Faiz, Alen, Ten Hacken, Nick H T, Timens, Wim, van Kuppevelt, Toin H, Daamen, Willeke, Hof, Danique, Harmsen, Martin C, Rojas, Mauricio, Heijink, Irene H

“…Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured…”
Get full text

Reciprocal regulation of endothelial–mesenchymal transition by MAPK7 and EZH2 in intimal hyperplasia and coronary artery disease by Vanchin, Byambasuren, Sol, Marloes, Gjaltema, Rutger A. F., Brinker, Marja, Kiers, Bianca, Pereira, Alexandre C., Harmsen, Martin C., Moonen, Jan-Renier A. J., Krenning, Guido

“…Endothelial–mesenchymal transition (EndMT) is a form of endothelial dysfunction wherein endothelial cells acquire a mesenchymal phenotype and lose endothelial…”
Get full text

Mesenchymal stem cells: promising for myocardial regeneration? by Przybyt, Ewa, Harmsen, Martin C

“…The pandemic of cardiovascular disease is continuously expanding as the result of changing life styles and diets throughout the Old and New World. Immediate…”
Get more information

Endothelial-mesenchymal transition in atherosclerosis by Souilhol, Celine, Harmsen, Martin C, Evans, Paul C, Krenning, Guido

“…Abstract Atherosclerosis is an inflammatory disease resulting in the hardening and thickening of the wall of arteries and the formation of plaques, which…”
Get full text

Fibroblasts alter the physical properties of dermal ECM-derived hydrogels to create a pro-angiogenic microenvironment by Zhang, Meng, Zhao, Fenghua, Zhang, Xue, Brouwer, Linda A., Burgess, Janette K., Harmsen, Martin C.

“…This study aimed to investigate the impact of fibroblasts (MRC-5) on the extracellular matrix (ECM) microenvironment of endothelial cells (ECs) during the…”
Get full text

Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis by Harmsen, Martin C., Moreira, Luiz Felipe Pinho, Kühn, Philipp Till, Barros, Guilherme Garcia, Liguori, Tácia Tavares Aquinas, Zhou, Qihui, Liguori, Gabriel Romero, van Rijn, Patrick

“…Introduction. Progenitor cells cultured on biomaterials with optimal physical-topographical properties respond with alignment and differentiation. Stromal…”
Get full text

Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage by Vriend, Linda, van der Lei, Berend, Harmsen, Martin C, van Dongen, Joris A

“…In recent decades, adipose tissue transplantation has become an essential treatment modality for tissue (volume) restoration and regeneration. The regenerative…”
Get full text

Endothelial progenitor cells give rise to pro-angiogenic smooth muscle-like progeny by Moonen, Jan-Renier A.J., Krenning, Guido, Brinker, Marja G.L., Koerts, Jasper A., van Luyn, Marja J.A., Harmsen, Martin C.

“…Aims Reciprocal plasticity exists between endothelial and mesenchymal lineages. For instance, mature endothelial cells adopt a smooth muscle-like phenotype…”
Get full text

IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration by Ovsiy, Ilja, Riabov, Vladimir, Manousaridis, Ioannis, Michel, Julia, Moganti, Kondaiah, Yin, Shuiping, Liu, Tengfei, Sticht, Carsten, Kremmer, Elisabeth, Harmsen, Martin C., Goerdt, Sergij, Gratchev, Alexei, Kzhyshkowska, Julia

“…Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show…”
Get full text